Age-related Changes in Human Retinal Microvasculature

人类视网膜微血管系统与年龄相关的变化

• 批准号: 9915922
• 负责人: Yuen Ping Toco Chui
• 金额: $ 41.94万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915922
• 关键词: Age; Aging; Alzheimer' s Disease; Angiography; Atherosclerosis; Biological Markers; Blood; Blood Flow Velocity; Blood Vessels; Blood capillaries; Blood flow; Caliber; Cells; Clinical; Data; Databases; Detection; Development; Diabetes Mellitus; Diabetic Retinopathy; Disease; Early Diagnosis; Erythrocytes; Evaluation; Eye; Eye diseases; Foundations; Frequencies; Functional Imaging; Geometry; Glaucoma; Goals; Grant; Human; Hypertension; Image; Imaging Techniques; Individual; Knowledge; Light; Link; Macular degeneration; Maintenance; Maps; Measurement; Microscopic; Monitor; Motion; Ophthalmoscopes; Ophthalmoscopy; Optical Coherence Tomography; Pathology; Patients; Physiological; Play; Population; Predisposition; Process; Reference Values; Reproducibility; Research; Retina; Retinal Degeneration; Retinal Diseases; Role; Scanning; Sickle Cell Anemia; Specificity; Structure; Systemic disease; Time; Translating; Translations; Travel; Variant; Vascular Diseases; Vision; Visualization; adaptive optics; age related; aging population; base; clinical care; contrast imaging; density; diabetic; diabetic patient; healthy aging; human imaging; imaging study; improved; in vivo imaging; individual variation; interest; light scattering; macula; nervous system disorder; neurovascular coupling; non-invasive imaging; normal aging; novel; predictive marker; prevent; retinal imaging; study population; treatment strategy

PROJECT SUMMARY /ABSTRACT Age-related degeneration of the retinal vasculature is one of the most pervasive developments in the aging eye, resulting in increased susceptibility to vision threatening ocular diseases. Diabetic retinopathy in many ways manifests as accelerated aging. Despite extensive research, quantitative data describing the dynamic changes that occur during normal aging of the human retinal vasculature are limited. Appreciation of individual variability in groups of healthy aging controls is critical for accurate interpretation of clinical results and planning research into new treatment strategies. Thus, there is a desperate need for quantitative normative data describing retinal vascular changes in the aging population. Such data will provide age-matched reference values for retinal vasculature measurements. Our central hypothesis is that this normative data is essential for understanding the impact of age-related changes on the progression of retinal vascular diseases, in order to successfully identify more sensitive and predictive biomarkers. The most advanced currently available noninvasive imaging techniques, adaptive optics scanning light ophthalmoscopy and optical coherence tomography angiography, will be used to study structure and function of the human retinal microvasculature in aging controls, and subjects with diabetic retinopathy. Three linking hypotheses will be evaluated for their ability to support our central hypothesis, (1) advancing our current in vivo imaging techniques, which allow the unprecedented ability to image and monitor the vascular cells down to the capillary level, can be used to document precise quantification of structural and functional features of aging and diseased retinas, (2) there are microvascular changes occurring in the healthy aging retina which need to be identified and accounted for in any evaluation of retinal vascular pathology, and (3) subclinical retinal changes in diabetic patients detectable using these imaging techniques that can be used to help differentiate pathology and distinguish changes from those which characterize normal aging. It is hoped that the knowledge generated by the proposed project will provide meaningful microvascular metrics and interpretations for translation to clinical care.

项目 概括 /抽象的 与年龄相关的视网膜脉管系统退化是衰老过程中最普遍的发展之一 眼睛，导致对威胁视力的眼部疾病的易感性增加。许多人患有糖尿病视网膜病变 方式表现为加速衰老。尽管进行了广泛的研究，描述动态的定量数据 人类视网膜血管系统正常衰老过程中发生的变化是有限的。个人欣赏 健康衰老对照组的变异性对于准确解释临床结果和规划至关重要 研究新的治疗策略。因此，迫切需要定量的规范数据 描述老龄化人群中视网膜血管的变化。这些数据将提供年龄匹配的参考 视网膜脉管系统测量值。我们的中心假设是，这些规范数据对于 了解年龄相关变化对视网膜血管疾病进展的影响，以便 成功识别出更敏感和更具预测性的生物标志物。目前最先进的 无创成像技术、自适应光学扫描光检眼镜和光学相干性 断层扫描血管造影将用于研究人类视网膜微血管的结构和功能 衰老对照者和患有糖尿病视网膜病变的受试者。将评估三个关联假设的效果 支持我们的中心假设的能力，（1）推进我们当前的体内成像技术，这使得 前所未有的对血管细胞进行成像和监测直至毛细血管水平的能力，可用于 记录老化和患病视网膜的结构和功能特征的精确量化，(2) 健康老化的视网膜中发生的微血管变化是否需要识别和解释 视网膜血管病理学的任何评估，以及（3）糖尿病患者的亚临床视网膜变化 使用这些成像技术可检测到，可用于帮助区分病理学和区分 与正常衰老特征相比发生的变化。希望所产生的知识 拟议的项目将提供有意义的微血管指标和解释，以转化为临床 关心。