BRAIN IMAGING INVESTIGATIONS OF UNIPOLAR DEPRESSED PATIENTS

单极抑郁症患者的脑成像研究

• 批准号: 7627521
• 负责人: JAIR C SOARES
• 金额: $ 4.61万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627521
• 关键词: Age; Basal Ganglia; Biochemical; Blood Platelets; Blood specimen; Brain; Brain imaging; Brain region; Brain scan; Computer Retrieval of Information on Scientific Projects Database; Condition; Densitometry; Depressed mood; Development; Educational Status; Functional disorder; Funding; Future; Grant; Inositol; Institution; Investigation; Lasers; Medial; Membrane; Mental Depression; Mood Disorders; Pathway interactions; Patients; Phosphatidylinositols; Population; Protons; Race; Research; Research Personnel; Resources; Scanning; Source; Suicide attempt; Symptoms; Temporal Lobe; Thin Layer Chromatography; Time; United States National Institutes of Health; clinically relevant; frontal lobe; in vivo; mood regulation; morphometry; myoinositol; neurochemistry; sex; suicidal behavior; suicidal risk; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: This study will examine the existence of particular in vivo neurochemical and morphometric brain abnormalities in unipolar mood disorder subjects, and their potential involvement in the pathophysiology of this illness. We will also examine potential in vivo brain correlates of prior suicidal behavior in this patient population. RESEARCH PLAN: We will investigate regional brain myo-inositol and platelet membrane phosphoinositide levels in 30 unmedicated unipolar patients (15 depressed and 15 in the remitted state) and 30 age, sex, educational level, and race-matched healthy controls. In addition to that, we will examine brain morphometry of key brain regions involved in mood regulation, to attempt to determine their relationship with illness symptoms. We will also examine brain correlates of suicide behavior by comparing patients with prior suicide attempts and the ones without such attempts. METHODS: All subjects undergo a 1.5T proton MIR/MRS brain scan, which allows the quantitation of myoinositol in 8cc brain voxels located in the frontal cortex, medial temporal lobe, and basal ganglia. At the same time, subjects provide a blood sample for platelet determination of membrane phosphoinositides, which is done with two-dimensional thin layer chromatography, followed by scanning laser densitometry. This research holds substantial promise to contribute to a better understanding of the biochemical brain dysfunction underlying mood disorders, and ultimately guide future efforts towards the development of new treatments for these conditions. CLINICAL RELEVANCE: This study will allow examination of involvement of abnormalities in the phosphoinositol (PI) pathway in pathophysiology of depression and mood disorders. It will also allow examination of anatomical involvement of specific brain regions participating in mood regulation in the pathophysiology of mood disorders. It could also possibly aid in development of new ways to identify depressed unipolar patients at high risk for suicide.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：这项研究将研究单极情绪障碍受试者中特定的体内神经化学和形态学脑异常，以及它们潜在参与该疾病的病理生理学。 我们还将检查该患者人群先前自杀行为的体内大脑相关性。 研究计划：我们将研究30名未经医学的单极患者（在寄回状态下15例抑郁症和15例）和30岁，性别，教育水平和种族匹配的健康控制措施，研究区域大脑肌醇和血小板磷酸肌醇水平。 除此之外，我们还将检查与情绪调节有关的关键大脑区域的大脑形态学，以确定其与疾病症状的关系。 我们还将通过比较先前自杀企图的患者以及没有这种尝试的患者来检查自杀行为的大脑相关性。 方法：所有受试者均接受1.5T质子miR/MRS脑扫描，该脑扫描允许在位于额叶皮层，内侧颞叶和基底神经节中的8cc脑体素中定量肌异素醇。 同时，受试者提供了一个血液样本，用于血小板测定膜磷酸肌醇，该血液用二维薄层色谱法完成，然后进行扫描激光密度测定法。 这项研究具有实质性的希望，可以更好地理解生化脑功能障碍潜在的情绪障碍，并最终指导未来为这些疾病开发新疗法的努力。 临床相关性：这项研究将允许检查抑郁症和情绪障碍病理生理学中磷酸肌醇（PI）途径异常的参与。 这还将允许检查参与情绪调节情绪障碍病理生理学的特定大脑区域的解剖学参与。 它还可能有助于开发新的方法，以识别自杀率高风险的单极抑郁症患者。