THE PATHOPHYSIOLOGY OF ORTHOSTATIC INTOLERANCE

直立不耐受的病理生理学

• 批准号: 7606947
• 负责人: ROY FREEMAN
• 金额: $ 3.35万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606947
• 关键词: Blood Plasma Volume; Cardiac; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Disease; Evaluation; Functional disorder; Funding; Grant; Institution; Pathogenesis; Physiological; Protocols documentation; Purpose; Reflex action; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Venous; Blood Plasma Volume; Cardiac; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Disease; Evaluation; Functional disorder; Funding; Grant; Institution; Pathogenesis; Physiological; Protocols documentation; Purpose; Reflex action; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Venous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to investigate the pathophysiology and pathogenesis of orthostatic intolerance by implementing an integrated physiological approach to cardiovascular control mechanisms in this disorder. Orthostatic intolerance is a consequence of one or more abnormalities in autonomic cardiovascular reflexes, cardiac function, plasma volume, neurohumoral factors, or venous compliance. The underlying mechanisms of orthostatic intolerance can be exposed by the evaluation of these factors.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该方案的目的是通过实施这种疾病中心血管控制机制的综合生理方法来研究直立性不耐受的病理生理和发病机理。体位不耐受是一个或多个自主性心血管反射，心脏功能，等离子体体积，神经肿瘤因子或静脉配合的异常。对这些因素的评估可以暴露于体位不耐受的基本机制。