BRAIN MYELIN INTEGRITY IN BIPOLAR DISORDER: AN IN VIVO MAGNETIC RESONANCE IMG

双相情感障碍中脑髓磷脂的完整性：体内磁共振 IMG

• 批准号: 7627540
• 负责人: JAIR C SOARES
• 金额: $ 1.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627540
• 关键词: Affect; Age; Anxiety Disorders; Axon; Bipolar Disorder; Brain; Brain region; Cerebral hemisphere; Chicago; Clinical; Communication; Computer Retrieval of Information on Scientific Projects Database; Computer software; Corpus Callosum; DSM-IV; Development; Diagnosis; Disease; Ethnic Origin; Female; Functional disorder; Funding; Gender; Grant; Hamilton Rating Scale for Depression; Hour; Image; Institution; Interview; Investigation; Israel; Magnetic Resonance; Magnetic Resonance Imaging; Manic; Measures; Medical; Mental disorders; Methods; Myelin; Nerve; Neurons; Patients; Persons; Pharmaceutical Preparations; Process; Protocols documentation; Psychiatric Diagnosis; Psychiatrist; Purpose; Rate; Recruitment Activity; Reporting; Research; Research Personnel; Resources; Severities; Signal Transduction; Source; Standards of Weights and Measures; Structure; Substance abuse problem; Symptoms; System; Therapeutic Intervention; Time; United States National Institutes of Health; Water; Week; base; clinically relevant; concept; in vivo; inclusion criteria; male; myelination; neuropsychological; research clinical testing; size; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: Until recently, brain myelin and white matter have not been a major focus of investigation in bipolar patients. Myelin (the white matter insulating the nerves), and factors that affect myelination are processes that could profoundly affect neuronal connectivity. Anatomical magnetic resonance imaging (MRI) studies have shown increased rates of white matter hyperintensifies in bipolar disorder, which might be disrupting connectivity among the brain structures implicated in the pathophysiology of this disorder. Recently, reports indicating smaller size and decreased MRI signal intensity in specific sub-regions of corpus callosum (a white matter midline structure that connects the two brain hemispheres, allowing inter-hemispheric communication) in bipolar patients have appeared. These findings suggest the involvement of myelin and white matter abnormalities in the pathophysiology of bipolar disorder. The purpose of this study is to examine whether there are regional myelin abnormalities in white matter brain regions in bipolar patients. RESEARCH PLAN: We propose to utilize a new method to measure myelin integrity, based on the three-pool concept, which proposes that myelin segregates water fractions into myelin, myelinated axons, and mixed pools. The three-pool method successfully estimated the rate and onset of myelination in our preliminary studies. We will study a group of 30 untreated bipolar patients and 30 matched healthy controls, using a 1.9 Tesla MRI magnet. METHODS: We will recruit a group of 30 untreated bipolar patients and 30 healthy controls matched for age, gender and ethnicity, for a total of 60 persons, over a 2-year period, both male and female, ages 18-75. Inclusion criteria for bipolar patients are: a) DSM-IV diagnosis of bipolar disorder type I; b) no substance abuse within the past 6 months; c) no current medical problems; d) not receiving psychotropic medications for at least two weeks at the time of participation in the study; and e) no comorbid psychiatric disorders, except for Anxiety Disorders. Psychiatric diagnosis will be established according to the DSM-IV criteria, using the SCID-IV Interview, and confirmed subsequently in a clinical evaluation by a research psychiatrist. The Hamilton Depression Rating Scale - 17 items and the Young Mania Rating Scale will be used to rate the severity of clinical symptoms. A standard neuropsychological battery will be administered at the time of entrance in the protocol to investigate the possibility of neuropsychological deficits. All subjects will undergo a brain MRI scan, which is performed in a single session and takes 2 hours. All images will be acquired on a large-bore 1.9 T MRI system (Elscint, Haifa, Israel). Statistical analyses will be performed using SPSS version 11.5 software (SPSS, Inc., Chicago, IL). CLINICAL RELEVANCE: This study will investigate, for the first time, brain myelin integrity in bipolar disorder, and by doing so, contribute to understanding the disease mechanisms involved. It could ultimately result in the development of new and more effective therapeutic interventions for this disorder.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：直到最近，在双极患者中，脑髓磷脂和白质还不是研究的重点。 髓磷脂（白质绝缘神经）以及影响髓鞘的因素是可以深远影响神经元连通性的过程。 解剖学磁共振成像（MRI）研究表明，躁郁症中白质超强度的速率增加，这可能会破坏与该疾病病理生理学有关的大脑结构之间的连通性。 最近，表明在双极患者中出现了大小较小和降低的MRI信号强度（白质中线结构，将两个脑半球连接起来，允许静脉间通信）中的MRI信号强度降低。 这些发现表明髓磷脂和白质异常参与了躁郁症的病理生理学。这项研究的目的是检查双极患者白质大脑区域中是否存在区域髓磷脂异常。 研究计划：我们建议利用一种基于三池概念的新方法来测量髓磷脂完整性，该概念提出髓磷脂将水分分离为髓磷脂，髓鞘轴突和混合池。 三池法在我们的初步研究中成功估计了髓鞘率的率和发作。 我们将使用1.9 Tesla MRI磁铁研究一组30例未经治疗的双极患者和30个匹配的健康对照。 方法：我们将招募一组未经治疗的双极患者和30例健康对照，以年龄，性别和种族匹配，总计60人，在2年的男性和女性中，年龄在2年内，年龄在18-75岁之间。 双极患者的纳入标准为：a）I型双相情感障碍的DSM-IV诊断； b）在过去6个月内没有滥用毒品； c）当前没有医疗问题； d）参与研究时至少两周未接受精神药物； e）除焦虑症外，没有合并症的精神病。 精神病诊断将根据DSM-IV标准建立，使用SCID-IV访谈，并随后在研究精神病医生的临床评估中确认。 汉密尔顿抑郁率评分量表-17个项目和年轻的躁狂评级量表将用于评估临床症状的严重程度。 协议进入时，将管理标准的神经心理电池，以研究神经心理缺陷的可能性。 所有受试者都会进行大脑MRI扫描，该扫描在一次会议中进行，需要2个小时。 所有图像将在大孔1.9 T MRI系统（Elscint，Haifa，以色列）上获取。 统计分析将使用SPSS版本11.5软件（SPSS，Inc。，芝加哥，伊利诺伊州）进行。 临床相关性：这项研究将首次研究双相情感障碍中的脑髓磷脂完整性，并通过此研究有助于理解所涉及的疾病机制。 它最终可能导致为这种疾病开发新的，更有效的治疗干预措施。