CLINICAL TRIAL OF IMMUNOTHERAPY WITH A CANDIDATE EXTRACT OF NON-AMMONIATED LATEX

使用非氨化乳胶候选提取物进行免疫治疗的临床试验

• 批准号: 7607448
• 负责人: FRANKLIN N ADKINSON
• 金额: $ 0.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607448
• 关键词: Allergic; Allergy Shot; Blood; Breathing; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Effectiveness; Environment; Funding; Grant; Health Personnel; Health Professional; Hypersensitivity skin testing; Immune system; Immunotherapy; Individual; Institution; Latex; Latex Particles; Latex allergy; Lung diseases; Methods; Monitor; Occupational; Research; Research Personnel; Resources; Safety; Source; Symptoms; Testing; United States National Institutes of Health; Work

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary reason for this study is to determine the general safety and effectiveness of latex allergy shots in latex allergic individuals. Complete avoidance of latex is the only current remedy for those that are allergic and this is often immpossible to achieve without an occupational change which could be economically impacting as well as sometimes unacceptable to health care professionals and others. Furthermore, some studies suggest that moving to a new environment where latex is absent or minimal may not be enough to avoid continuing symptoms or to help with respiratory disease. The need for additional options is therefore very important. There is reason to believe that treatment with regular latex shots similar to traditional allergy shots, may be successful in reducing latex allergy. During this study, we will monitor the effects of the latex shots on the immune systems of our subjects by gathering evidence from several testing methods. Results from blood work, skin testing and challenges of breathing latex particles will be the testing methods we will be using. The results of this study will tell us if this is a practical, effective and safe form of possible treatment for health care workers and people with latex allergy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的主要原因是确定乳胶过敏个体中乳胶过敏镜头的一般安全性和有效性。对于那些过敏的人来说，完全避免乳胶是目前的唯一补救措施，而这通常是可以实现的，而无需职业变化，这在经济上可能会产生经济影响，有时甚至是医疗保健专业人员和其他人都无法接受的。 此外，一些研究表明，迁移到缺乏乳胶或最少的新环境可能不足以避免持续的症状或帮助呼吸道疾病。 因此，需要其他选择非常重要。有理由相信，与传统过敏相似的常规乳胶镜头治疗可能会成功减少乳胶过敏。 在这项研究中，我们将通过从多种测试方法中收集证据来监视乳胶镜头对受试者免疫系统的影响。血液工作，皮肤测试和呼吸乳胶颗粒的挑战的结果将是我们将使用的测试方法。这项研究的结果将告诉我们这是否是对乳胶过敏的医疗保健工作者和患者的实用，有效和安全的治疗形式。