GROAG

格罗阿格

• 批准号: 7607839
• 负责人: LESLIE SARGENT JONES
• 金额: $ 0.08万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607839
• 关键词: African American; Blindness; Blood specimen; Clinic; Clinical; Computer Retrieval of Information on Scientific Projects Database; Detection; Disease; Disease Progression; Early treatment; Eye; Family; Funding; Genes; Genetic Variation; Glaucoma; Goals; Grant; Individual; Institution; Iowa; Monitor; Ophthalmic examination and evaluation; Optic Nerve; Optical Coherence Tomography; Patients; Primary Open Angle Glaucoma; Research; Research Design; Research Personnel; Resources; Retinal; Risk; Source; United States National Institutes of Health; Universities; genetic linkage analysis; pressure; tomography

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glaucoma is a group of diseases characterized by progressive damage of the optic nerve and irreversible loss of vision. One of the most prevalent forms is primary open angle glaucoma (POAG) with approximately 33.1 million sufferers around the world. Early treatment for individuals suspected of having glaucoma and for those with early glaucoma slow the progression of the disease; thus, a major goal of glaucoma research is identifying individuals at high-risk for glaucoma for intense monitoring and early treatment. Identifying genes associated with developing glaucoma is a potential component of early risk detection. This is a study designed to 1) identify genes and genetic variations within the genes which cause glaucoma and 20 identify the clinical features associated with these genetic variations. It will include 1500 African Americans from Howard University eye clinics, 1000 with primary open angle glaucoma (POAG) and 500 as controls as well as 10 multiple case families. Patients will receive a comprehensive eye examination, eye pressure assessment, retinal tomography and optical coherence tomography. Blood samples will be stored in the HU Biobank and transported to University of Iowa for gene screen and linkage analysis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 青光眼是一组疾病，其特征是视神经的进行性损害和视力丧失。最普遍的形式之一是主要的开头青光眼（POAG），全球约有3310万患者。对怀疑患有青光眼和青光眼早期患者的患者的早期治疗也降低了疾病的进展；因此，青光眼研究的主要目标是鉴定高风险的人群以进行青光眼进行严格的监测和早期治疗。识别与发展青光眼相关的基因是早期风险检测的潜在组成部分。 这是一项旨在的研究，旨在确定引起青光眼的基因和遗传变异，并确定20个与这些遗传变异相关的临床特征。它将包括来自霍华德大学眼诊所的1500名非裔美国人，1000名具有原发性开头青光眼（POAG）和500个作为对照和10个多个病例家族的非裔美国人。患者将接受全面的眼睛检查，眼压评估，视网膜断层扫描和光学相干断层扫描。血样将存储在HU生物库中，并运送到爱荷华大学进行基因筛查和连锁分析。