WELL BEING IN HEART FAILURE PATIENTS PRACTICING TAI CHI

练习太极拳对心力衰竭患者的健康有益

• 批准号: 7606587
• 负责人: Laura S Redwine
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606587
• 关键词: Beck depression inventory; Cardiomyopathies; Cities; Computer Retrieval of Information on Scientific Projects Database; Condition; Congestive Heart Failure; Depressed mood; Elderly; Epinephrine; Exercise; Fatigue; Feeling hopeless; Funding; Grant; Health education; Heart failure; Hormones; Hydrocortisone; Institution; Interferons; Interleukin-10; Interleukin-6; Intervention; Kansas; Living Wills; Mediating; Medical Education; Moods; Norepinephrine; Outcome; Participant; Patients; Personal Satisfaction; Quality of life; Questionnaires; Randomized; Relative (related person); Research; Research Personnel; Resources; Severities; Source; Stress; TNF gene; Tai Ji; Testing; Training; United States National Institutes of Health; Walking; Week; cytokine; health related quality of life; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1. To determine the relative effects of the Tai Chi intervention, walking exercise program and health- education in older adults with congestive heart failure at 12 and 24 weeks post-intervention on well-being: (a) mood, Beck Depression Inventory (BDI) (b) health related quality of life, Kansas City Cardiomyopathy Questionnaire (KCCQ) and (c) fatigue, Fatigue Severity Scale. Hypothesis 1.A. Participants with congestive heart failure randomized to the Tai Chi group will show significant increases in well-being, including greater reductions in depressed mood and hopelessness, increases in quality of life and decreases in fatigue 12 and 24 weeks post-intervention relative to participants randomized to walking exercise or medical education groups. Hypothesis 1.B. Participants with congestive heart failure randomized to the exercise group will show significant increases in well-being, including greater reductions in depressed mood, hopelessness, increases in quality of life and decreases in fatigue 12 and 24 weeks post-intervention relative to participants randomized into the medical education group. AIM 2. To determine the relative effects of Tai Chi training, walking exercise program and health-education on cytokines (TNF, IL-6, IFN, IL-10) and stress hormone (norepinephrine, epinephrine and cortisol) profiles in older adults with congestive heart failure, at 12 and 24 weeks post-intervention. Hypothesis 2.A. Participants with congestive heart failure randomized to the Tai Chi group will show significant reductions in proinflammatory cytokines, TNF and IL-6 and increases in the Th1/Th2 ratio (IFN /IL-10) 12 and 24 weeks after intervention relative to participants randomized to walking exercise and health-education groups. Hypothesis 2.B. Participants with congestive heart failure randomized to the walking exercise group will show significantly greater reductions in proinflammatory cytokines, TNF and IL-6 and increases in the Th1/Th2 ratio (IFN/IL-10) 12 and 24 weeks after intervention relative to the participants randomized to the health-education group. Hypothesis 2.C. The relationship between condition assignment and quality of life will be mediated by reductions in proinflammatory cytokines, TNF and IL-6 and increases in IFN /IL-10 ratios. AIM 3. To determine the relative effect of Tai Chi practice, walking exercise and health education on secondary outcomes, BNP, and six minute walk test 12 and 24 weeks post-intervention in patients with congestive heart failure. Hypothesis 3. Participants with congestive heart failure randomized to the Tai Chi group will show significant reductions in BNP levels and increases in distance walked in the six minute walk test at 12 and 24 weeks post-intervention.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 AIM 1. To determine the relative effects of the Tai Chi intervention, walking exercise program and health- education in older adults with congestive heart failure at 12 and 24 weeks post-intervention on well-being: (a) mood, Beck Depression Inventory (BDI) (b) health related quality of life, Kansas City Cardiomyopathy Questionnaire (KCCQ) and (c) fatigue, Fatigue Severity Scale. 假设1.a。充血性心力衰竭的参与者将随机分为太极拳组将显示出大幅度增加的福祉，包括情绪低落和绝望的降低，生活质量的提高以及疲劳后12和24周的疲劳相对于随机进行步行锻炼或医学教育小组的疲劳减轻。 假设1.B.随机分配到运动组的充血性心力衰竭的参与者将表现出良好的健康状况增加，包括情绪低落，绝望，生活质量的提高以及疲劳后12和24周的疲劳减少，相对于随机加入医学教育组的参与者。 目的2。确定Tai Chi训练，步行锻炼计划和健康教育对细胞因子（TNF，IL-6，IFN，IL-10）和应激激素（去甲肾上腺素，肾上腺素和皮质醇）的相对影响，对年龄较大的老年人，患有心脏失败的老年人，Intervention，Interventive the Interteventive。 假设2.a。随机分配到TAI CHI组的一致性心力衰竭的参与者将显示促炎细胞因子TNF和IL-6的显着降低，而TH1 /TH2比（IFN /IL-10）的增加（IFN /IL-10）12和24周与参与者进行了随机分配给步行运动和健康教育组后的干预后，这将显着减少。 假设2.b。随机分配到步行运动组的充血性心力衰竭的参与者将显示出促炎性细胞因子TNF和IL-6的降低明显降低，而TH1/TH2比（IFN/IL-10）的增加（IFN/IL-10）12和24周后相对于参与者随机分配给健康教育组的参与者。 假设2.C.条件分配和生活质量之间的关系将通过减少 促炎细胞因子TNF和IL-6，IFN /IL-10比增加。 目的3。确定泰思实践，步行锻炼和健康教育对次要结果的相对影响，BNP和六分钟步行测试在干预后12和24周对充血性心力衰竭的患者进行。 假设3。充血性心力衰竭随机分为太极拳组的参与者将显示BNP水平的显着降低，并在干预后12和24周的六分钟步行测试中的距离增加。