WELL BEING IN HEART FAILURE PATIENTS PRACTICING TAI CHI

练习太极拳对心力衰竭患者的健康有益

• 批准号: 7606587
• 负责人: Laura S Redwine
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606587
• 关键词: Beck depression inventory; Cardiomyopathies; Cities; Computer Retrieval of Information on Scientific Projects Database; Condition; Congestive Heart Failure; Depressed mood; Elderly; Epinephrine; Exercise; Fatigue; Feeling hopeless; Funding; Grant; Health education; Heart failure; Hormones; Hydrocortisone; Institution; Interferons; Interleukin-10; Interleukin-6; Intervention; Kansas; Living Wills; Mediating; Medical Education; Moods; Norepinephrine; Outcome; Participant; Patients; Personal Satisfaction; Quality of life; Questionnaires; Randomized; Relative (related person); Research; Research Personnel; Resources; Severities; Source; Stress; TNF gene; Tai Ji; Testing; Training; United States National Institutes of Health; Walking; Week; cytokine; health related quality of life; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1. To determine the relative effects of the Tai Chi intervention, walking exercise program and health- education in older adults with congestive heart failure at 12 and 24 weeks post-intervention on well-being: (a) mood, Beck Depression Inventory (BDI) (b) health related quality of life, Kansas City Cardiomyopathy Questionnaire (KCCQ) and (c) fatigue, Fatigue Severity Scale. Hypothesis 1.A. Participants with congestive heart failure randomized to the Tai Chi group will show significant increases in well-being, including greater reductions in depressed mood and hopelessness, increases in quality of life and decreases in fatigue 12 and 24 weeks post-intervention relative to participants randomized to walking exercise or medical education groups. Hypothesis 1.B. Participants with congestive heart failure randomized to the exercise group will show significant increases in well-being, including greater reductions in depressed mood, hopelessness, increases in quality of life and decreases in fatigue 12 and 24 weeks post-intervention relative to participants randomized into the medical education group. AIM 2. To determine the relative effects of Tai Chi training, walking exercise program and health-education on cytokines (TNF, IL-6, IFN, IL-10) and stress hormone (norepinephrine, epinephrine and cortisol) profiles in older adults with congestive heart failure, at 12 and 24 weeks post-intervention. Hypothesis 2.A. Participants with congestive heart failure randomized to the Tai Chi group will show significant reductions in proinflammatory cytokines, TNF and IL-6 and increases in the Th1/Th2 ratio (IFN /IL-10) 12 and 24 weeks after intervention relative to participants randomized to walking exercise and health-education groups. Hypothesis 2.B. Participants with congestive heart failure randomized to the walking exercise group will show significantly greater reductions in proinflammatory cytokines, TNF and IL-6 and increases in the Th1/Th2 ratio (IFN/IL-10) 12 and 24 weeks after intervention relative to the participants randomized to the health-education group. Hypothesis 2.C. The relationship between condition assignment and quality of life will be mediated by reductions in proinflammatory cytokines, TNF and IL-6 and increases in IFN /IL-10 ratios. AIM 3. To determine the relative effect of Tai Chi practice, walking exercise and health education on secondary outcomes, BNP, and six minute walk test 12 and 24 weeks post-intervention in patients with congestive heart failure. Hypothesis 3. Participants with congestive heart failure randomized to the Tai Chi group will show significant reductions in BNP levels and increases in distance walked in the six minute walk test at 12 and 24 weeks post-intervention.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的 1. 确定太极干预、步行锻炼计划和健康教育对患有充血性心力衰竭的老年人在干预后 12 周和 24 周对健康的相对影响：(a) 情绪、贝克抑郁量表 ( BDI) (b) 健康相关生活质量、堪萨斯城心肌病问卷 (KCCQ) 和 (c) 疲劳、疲劳严重程度量表。 假设 1.A.与随机分组的参与者相比，随机分配到太极组的患有充血性心力衰竭的参与者在干预后 12 周和 24 周将表现出健康状况的显着提高，包括抑郁情绪和绝望感的更大程度减少、生活质量的提高以及疲劳的减少。步行锻炼或医学教育小组。 假设1.B。与随机分配到运动组的参与者相比，随机分配到运动组的患有充血性心力衰竭的参与者在干预后 12 周和 24 周将表现出健康状况的显着提高，包括抑郁情绪、绝望感的更大程度减轻，生活质量的提高以及疲劳程度的减轻。医学教育组。 目的 2. 确定太极拳训练、步行锻炼计划和健康教育对老年痴呆症患者细胞因子（TNF、IL-6、IFN、IL-10）和应激激素（去甲肾上腺素、肾上腺素和皮质醇）谱的相对影响干预后 12 周和 24 周出现充血性心力衰竭。 假设 2.A.与随机分配到太极组的充血性心力衰竭参与者相比，干预后 12 周和 24 周，促炎细胞因子、TNF 和 IL-6 显着减少，Th1/Th2 比率 (IFN /IL-10) 增加。步行锻炼和健康教育小组。 假设2.B。与参与者相比，随机分配到步行运动组的充血性心力衰竭参与者在干预后 12 周和 24 周时，促炎细胞因子、TNF 和 IL-6 显着减少，Th1/Th2 比率 (IFN/IL-10) 显着增加。随机分配到健康教育组。 假设2.C。条件分配和生活质量之间的关系将通过减少 促炎细胞因子、TNF 和 IL-6 以及 IFN/IL-10 比率增加。 目的 3. 确定太极拳练习、步行锻炼和健康教育对充血性心力衰竭患者干预后 12 周和 24 周的次要结果、BNP 和六分钟步行测试的相对影响。 假设 3：患有充血性心力衰竭的参与者被随机分配到太极拳组，在干预后 12 周和 24 周的六分钟步行测试中，BNP 水平显着降低，步行距离增加。