BONE MASS, BONE TURNOVER, AND HOMOCYSTEINE LEVELS IN YOUNG WOMEN ON AEDS

服用 AEDS 的年轻女性的骨量、骨转换率和同型半胱氨酸水平

• 批准号: 7606462
• 负责人: CHERYL P SHORE
• 金额: $ 0.03万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606462
• 关键词: Adverse effects; Age; Antiepileptic Agents; Behavior; Bone Density; Calcium; Computer Retrieval of Information on Scientific Projects Database; Diet; Epilepsy; Fracture; Funding; Goals; Grant; Homocysteine; Homocystine; Individual; Institution; Lead; Life Style; Measurement; Measures; Metabolic; Osteoporosis; Patient Self-Report; Pilot Projects; Populations at Risk; Prevention; Public Health; Purpose; Quality of life; Recommendation; Recruitment Activity; Research; Research Personnel; Resources; Risk; Sampling; Seizures; Serum; Source; Supplementation; United States National Institutes of Health; Vitamin B Complex; Vitamin D; Woman; bone; bone health; bone turnover; design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alterations in bone health have been discovered in a significant proportion of individuals taking antiepileptic drugs to control seizures, increasing their risk for fractures. The mechanism(s) responsible for alternations in bone dynamics have been elusive, however. Homocysteine levels have been related to bone mineral density in recent research. The purpose of this study is to explore and describe relationships among bone mineral density, indicators of bone turnover, serum homocysteine, and lifestyle factors in young women who have epilepsy. If relationships between homocysteine and bone turnover and/or bone mineral density are demonstrated, prevention may involve B vitamin supplementation in addition to the current recommendation of calcium and vitamin D The proposed study will use a cross-sectional, correlational design. Ten women age 18 to 30 will be recruited. Because this is a small pilot study, the sample will be homogeneous. Measurements of bone mineral density, metabolic indicators of bone turnover, homocysteine, plus self-report measures of diet and activity behaviors will be collected. Relationships among the variables will be examined. Values for bone mineral density, indicators of bone turnover, and homocysteine levels will also be compared to normative values. The results of this study may lead to improvement in quality of life for people with epilepsy, allowing them to maintain seizure control while managing the risk for altered bone health, thus supporting the goal of "no seizures, no side effects". Within a public health context, the results of this study could lead to fewer people in the population at risk for osteoporosis

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在很大一部分服用抗癫痫药物来控制癫痫发作的个体中发现了骨骼健康的改变，增加了骨折的风险。但是，负责骨动力学交替的机制是难以捉摸的。在最近的研究中，同型半胱氨酸水平与骨矿物质密度有关。这项研究的目的是探索和描述骨矿物质密度，骨转换指标，血清同型半胱氨酸的指标以及患有癫痫病的年轻女性的生活方式因素。如果证明了同型半胱氨酸和/或骨矿物质密度之间的关系，则除了当前的钙和维生素D的建议外，还可能涉及B维生素补充剂 拟议的研究将使用横截面相关设计。将招募十名18至30岁的女性。因为这是一项小型试点研究，所以样本将是均匀的。将收集骨矿物质密度，骨转换的代谢指标，同型半胱氨酸的代谢指标，以及饮食和活动行为的自我报告。将检查变量之间的关系。骨矿物质密度，骨转换指标和同型半胱氨酸水平的值也将与规范值进行比较。 这项研究的结果可能会导致癫痫患者的生活质量改善，使他们能够保持癫痫发作控制，同时管理改变骨骼健康的风险，从而支持“无癫痫发作，无副作用”的目标。在公共卫生的情况下，这项研究的结果可能导致人口中有骨质疏松症风险的人数减少