A COMPARISON OF AIRWAY CLEARANCE EFFICACY OF SINE WAVE AND TRIANGULAR WAVE HIGH

正弦波与三角波高气道清除效率比较

• 批准号: 7606073
• 负责人: Robert R KEMPAINEN
• 金额: $ 1.35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606073
• 关键词: Agreement; Air; Chest; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Daily; Devices; Drainage procedure; Excision; Funding; Grant; High-Frequency Chest Wall Compression; Institution; Lung; Minnesota; Mucous body substance; Patients; Physiologic pulse; Pulse taking; Research; Research Personnel; Resources; Source; System; Techniques; United States; United States National Institutes of Health; Universities; cystic fibrosis patients; design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with cystic fibrosis (CF) must perform daily bronchial drainage therapy (BD) to keep their airways clear of secretions. Many different techniques are available to achieve this and there is currently no agreement as to which form of therapy is most effective. High frequency chest wall oscillation (HFCWO) was developed at the Minnesota CF Center and currently it is used by CF patients throughout the United States and abroad. To perform this therapy, the patient wears a vest which fits over the entire torso and is connected to an air compressor. The compressor generates oscillating air pulses that are transmitted to the lungs, thereby mobilizing secretions. The oscillations produced by the most commonly used device have a sinusoidal wave form (The Vest Airway Clearance System, Hill-Rom Inc, St. Paul, MN). Previous studies indicate this form of therapy is as effective as more tradtional cumbersome forms of therapy. The design of the pulse generator has been recently modified so that the oscillations produced have a triangular wave form (Respitech, Inc, MN). Studies done at the University of Minesota found that the air flows induced in the airways can vary substantially depending on the wave form applied to the chest. At present, the impact of using a triangular wave form on mucus removal is unknown. The proposed study will compare mucous clearance using a device generating sine wave oscillations to a device generating triangular wave oscillations.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 囊性纤维化 (CF) 患者必须每天进行支气管引流治疗 (BD)，以保持气道无分泌物。有许多不同的技术可以实现这一目标，但目前对于哪种治疗形式最有效尚未达成一致。高频胸壁振荡 (HFCWO) 是由明尼苏达 CF 中心开发的，目前被美国和国外的 CF 患者使用。为了进行这种治疗，患者穿着一件适合整个躯干的背心，并连接到空气压缩机。压缩机产生振荡空气脉冲，传送到肺部，从而动员分泌物。最常用的设备产生的振荡具有正弦波形式（The Vest Airway Clearance System，Hill-Rom Inc，St. Paul，MN）。先前的研究表明，这种疗法与更传统的繁琐疗法一样有效。脉冲发生器的设计最近经过修改，产生的振荡具有三角波形式（Respitech, Inc, MN）。明尼苏达大学进行的研究发现，气道中引起的气流可能会根据施加到胸部的波形而发生很大变化。目前，使用三角波形式对粘液去除的影响尚不清楚。拟议的研究将比较使用产生正弦波振荡的装置和产生三角波振荡的装置的粘液清除率。