AGING AND ALZHEIMER'S DISEASE BIOSAMPLE REPOSITORY

衰老和阿尔茨海默病生物样本库

• 批准号: 7606237
• 负责人: Robert C. Green
• 金额: $ 1.04万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606237
• 关键词: Age-Related Memory Disorders; Aging; Alzheimer' s Disease; Area; Biological; Blood; Boston; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; DNA; Dementia; Funding; Future; Goals; Grant; Incentives; Incidence; Institution; Intention; Memory Disorders; Morbidity - disease rate; Numbers; Participant; Plasma; Policies; Protocols documentation; Research; Research Personnel; Resources; Sampling; Source; Time; United States National Institutes of Health; Universities; desire; disorder risk; interest; preference; repository; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Boston University Alzheimer's Disease Center (BU ADC) has for many years been involved in multiple clinical research studies looking at aging and age-related memory disorders, including Alzheimer's disease. The participants in these studies are motivated by a desire to help decrease the incidence and morbidity of dementia. The vast majority of participants are willing to donate blood, including DNA samples, towards this cause. At the same time, many researchers are looking for markers of disease risk in blood components (e.g., DNA, serum/plasma). The Boston University Aging and Alzheimer's Disease BioSample Repository was conceived as a way of bringing together the interests of researchers and participants in a manner that would be optimally beneficial to both groups. A repository at BU would allow participants to contribute to a greater number of studies in a research area in which they have a declared intention to contribute. Researchers would then have a pool of available biological components to access. Furthermore, future research efforts at the BU ADC will have an established protocol and storage for biological samples, creating an incentive to pursue more creative research in the area of aging and memory disorders. These goals are consistent with the requirements of the NIA-funded Alzheimer's Disease Center at Boston University and with stated sharing policies and preferences of NIA and NIH.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 波士顿大学阿尔茨海默氏病中心（BU ADC）多年来参与了多项临床研究，研究了包括老年人和年龄有关的记忆障碍，包括阿尔茨海默氏病。 这些研究的参与者是出于渴望减少痴呆症的发病率和发病率的愿望。 绝大多数参与者愿意向这一原因捐赠包括DNA样本在内的血液。 同时，许多研究人员正在寻找血液成分中疾病风险的标志物（例如DNA，血清/血浆）。 波士顿大学的老化和阿尔茨海默氏病生物样品存储库被认为是一种将研究人员和参与者的利益汇集在一起​​，以对这两个群体都具有最佳有益的方式。 BU的存储库将允许参与者在他们宣布贡献意图的研究领域中为更多的研究做出贡献。 然后，研究人员将拥有可用的生物学成分池。 此外，BU ADC的未来研究工作将制定生物样品的既定协议和存储，从而激励在衰老和记忆障碍领域进行更多创造性的研究。 这些目标与波士顿大学的NIA资助的阿尔茨海默氏病中心的要求一致，并带有NIA和NIH的分享政策和偏好。