EARLY IDENTIFICATION OF SUBCLINICAL ATHEROSCLEROSIS USING NONINVASIVE IMAGING

使用无创成像早期识别亚临床动脉粥样硬化

• 批准号: 7606128
• 负责人: Daniel S Berman
• 金额: $ 19.4万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606128
• 关键词: Atherosclerosis; Biochemical Markers; Calcium; Cardiac; Clinic Visits; Clinical; Clinical Markers; Computer Retrieval of Information on Scientific Projects Database; Coronary; Coronary Arteriosclerosis; Counseling; Diagnosis; Early Diagnosis; Early identification; Employee; Family; Foundations; Friends; Funding; Grant; Heart Research; Image; Institution; Mails; Medical center; Modification; Monitor; Outcome; Participant; Population Study; Predictive Value; Procedures; Program Research Project Grants; Questionnaires; Randomized; Research; Research Personnel; Resources; Risk Assessment; Risk Estimate; Risk Factors; Scanning; Source; Standards of Weights and Measures; United States National Institutes of Health; Visit; X-Ray Computed Tomography; aged; base; coronary artery calcification; programs; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Early Identification of subclinical Atherosclerosis using noninvasive Imaging Research (EISNER) is a multi-project research program funded by The Eisner Foundation. The primary objective of the research program is to investigate the predictive value of coronary calcium by cardiac CT in combination with clinical, standard and new biochemical markers for clinical outcomes in the early detection and management of coronary artery disease (CAD). This project includes five studies. In EISNER Heart Study 1, the study population will be comprised of 2,250 asymptomatic employees and volunteers of Cedars-Sinai Medical Center and their family and friends, aged 35-80, inclusive, who have never been diagnosed with coronary artery disease. Study procedures include a baseline clinic visit during which participants will undergo cardiac risk assessments to determine their estimated risk for developing CAD. Participants will then be randomized to either have a cardiac CT scan for coronary calcification or not in a 2:1 ratio. At the end of baseline, participants will receive counseling on risk factor modification based on the risk assessment and the results of the cardiac CT scan, if they undergo the scan. Questionnaire will be administered annually by mail to monitor clinical outcomes and risk factor modification. At Year 4, all participants will return for a clinic visit to repeat the cardiac risk assessment procedures and receive a cardiac CT scan. All participants will receive a cardiac CT scan at the Year 4 visit.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 使用非侵入成像研究（Eisner）对亚临床动脉粥样硬化的早期鉴定是由Eisner基金会资助的多项目研究计划。该研究计划的主要目的是研究心脏CT冠状动脉钙的预测价值与临床，标准和新的生化标记，用于早期检测和管理冠状动脉疾病（CAD）的临床结果。该项目包括五项研究。 在Eisner Heart研究1中，研究人群将由2,250名无症状的雇员和Cedars-Sinai Medical Center的志愿者及其家人和朋友（35-80岁）组成，包括从未被诊断出患有冠状动脉疾病。研究程序包括基线诊所就诊，在此期间，参与者将接受心脏风险评估，以确定其估计开发CAD的风险。然后，参与者将随机分配以进行冠状动脉钙化的心脏CT扫描，或以2：1的比例。在基准结束时，参与者将根据风险评估和心脏CT扫描结果（如果接受扫描）进行咨询。问卷将每年通过邮件管理，以监视临床结果和风险因素修改。在第4年，所有参与者将返回诊所就诊，以重复心脏风险评估程序并接受心脏CT扫描。所有参与者将在4年级访问中获得心脏CT扫描。