MICROCIRCULATORY OXYGEN TRANSPORT ASSESSMENT OF THE ACUTE AND SUBACUTE CONGES

急性和亚急性充血的微循环氧输送评估

• 批准号: 7605043
• 负责人: CHRISTOPHER J HOGAN
• 金额: $ 0.11万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-20 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605043
• 关键词: Acute; Aftercare; Behavior; Cardiovascular Diseases; Chest; Clinic; Computer Retrieval of Information on Scientific Projects Database; Death Rate; Evaluation; Funding; Goals; Grant; Healthcare; Heart failure; Inpatients; Institution; Invasive; Measures; Monitor; Outcome; Outpatients; Patients; Perfusion; Physical assessment; Physicians; Population; Quantitative Evaluations; Rate; Research; Research Personnel; Resources; Severities; Source; Symptoms; Techniques; Time; Tissues; United States National Institutes of Health; Week; mortality; oxygen transport; recidivism; response; technology/technique; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Heart Failure (HF) is a prevalent and growing cardiovascular disorder that utilizes a tremendous portion of healthcare resources. Current quantitative evaluation techniques are invasive and yield limited, one time information about HF, which itself is poorly understood. In both outpatient and inpatient settings, evaluation is limited to chest radiographs and physical assessment, which prior studies have shown to have poor accuracy in detecting HF severity and in guiding treatment. Recently developed noninvasive monitoring techniques and technologies are now available which in preliminary studies suggest the perfusion status of these patients is significantly reduced and impacted minimally by inpatient treatment. Our goal in this study is to use noninvasive monitoring techniques in the symptomatic hospitalized HF population to further define the relationship between tissue oxygen transport, patient symptoms, traditional physician assessment and treatment, as well as recidivism. Discharged inpatients and stable clinic patients will be serially reassessed to determine the behavior of oxygen transport and utilization over time. These values will be evaluated to determine if they approach those of the stable outpatient heart failure population. We hypothesize perfusion parameters and their rate of change during treatment and after discharge will be sensitive predictors of HF outcome and mortality. IV. Specific Aims 1. To characterize global and tissue specific oxygen transport parameters in HF patients who are acutely symptomatic and more closely trend their responses to treatment. 2. To compare global and tissue specific oxygen transport parameters with the severity of patient symptoms and physician assessment. 3. To compare systemic and tissue specific oxygen transport parameters with 6 month rates of readmission and death rates after discharge from the ED or inpatient setting. 4. To compare systemic and tissue specific oxygen transport parameters with Doppler echocardiographic variables, lactate and BNP levels. 5. To measure systemic and tissue specific oxygen transport parameters during the first 4 weeks after hospitalized inpatients have been discharged and compare these values and trends of stable HF patients who will be reassessed over 3 months.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 心力衰竭（HF）是一种普遍存在的心血管疾病，利用了大部分医疗保健资源。 当前的定量评估技术是侵入性的，产量有限，一次有关HF的信息，本身对此知之甚少。 在门诊和住院环境中，评估仅限于胸部X光片和身体评估，先前的研究表明，在检测HF严重程度和指导治疗方面的准确性较差。 最近开发的非侵入性监测技术和技术现已可用，在初步研究中表明，这些患者的灌注状态大大降低并受到住院治疗的影响。 我们在这项研究中的目标是在有症状的住院HF人群中使用非侵入性监测技术来进一步定义组织氧运输，患者症状，传统医师评估和治疗以及累犯之间的关系。 出院的住院患者和稳定的诊所患者将串行重新评估，以确定随着时间的推移氧运输和利用的行为。 将评估这些值，以确定它们是否接近稳定的门诊心力衰竭人群的值。 我们假设灌注参数及其在治疗过程中的变化率，并且出院后将是HF结果和死亡率的敏感预测指标。 iv。 具体目标 1。表征HF患者的全球和组织特异性氧气转运参数，这些患者敏锐地症状，更紧密地趋向其对治疗的反应。 2。将全球和组织特异性氧的转运参数与患者症状和医师评估的严重程度进行比较。 3。要比较从ED或住院设置出院后的系统和组织特异性氧气转运参数和6个月的再入院率和死亡率。 4。将系统和组织特异性氧的传输参数与多普勒超声心动图变量，乳酸和BNP水平进行比较。 5。为了在住院住院治疗后的前4周内测量系统性和组织特异性氧的转运参数，并比较将在3个月内重新评估稳定的HF患者的这些价值和趋势。