Kerala-Einstein study: Risk factors for cognitive decline

喀拉拉-爱因斯坦研究：认知能力下降的危险因素

• 批准号: 7643977
• 负责人: JOE VERGHESE
• 金额: $ 10.41万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7643977
• 关键词: Address; Adult; Age; Aging; Behavioral; Brain; Brain Diseases; Cardiovascular Diseases; Caring; Case-Control Studies; Cerebrovascular Disorders; Chitra; Cities; Clinic; Clinical; Cognitive; Cohort Studies; Collaborations; Communities; Community Workers; Consultations; Data; Databases; Dementia; Developed Countries; Developing Countries; Diagnostic; Diagnostic Procedure; Disease; Education; Elderly; Environmental Exposure; Environmental Risk Factor; Faculty; Fostering; Foundations; Future; Gait abnormality; Goals; Grant; Health; Hospitals; Impaired cognition; India; Institutes; Institution; Interview; Joints; Leisure Activities; Life; Longitudinal Studies; Malignant Neoplasms; Maps; Medical; Medicine; Memory impairment; Motor; Neurologic; Neurologist; Neurology; Outcome; Pathologist; Policies; Population; Prevalence; Prevention; Protocols documentation; Public Health; Recruitment Activity; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Risk Factors; Role; Sampling; Services; Site; Spinal cord injury; Time; Training; age related; base; cardiovascular risk factor; clinical practice; cohort; college; computerized; design; disability; disability weights; experience; gene environment interaction; instrument; lifestyle factors; member; mild neurocognitive impairment; multidisciplinary; population based; prospective; public health relevance; sex; socioeconomics

DESCRIPTION (provided by applicant): This revised R21 grant is designed to foster collaborative research to study risk factors for cognitive decline among older adults living in the Indian state of Kerala. Our research sites are the cities of Kozhikode and Thiruvananthapuram in Kerala. The proposal will be directed by Dr Verghese, a neurologist at the Albert Einstein College of Medicine and a native of Kerala in collaboration with Dr. Mathuranath, Director, Division of Behavioral Neurology at the Sri Chitra Tirunal Institute, Thiruvananthapuram, one of India's premier postgraduate medical institutes and Dr Salam, Director of Neurology at Baby Memorial Hospital, Kozhikode. We have entitled this collaboration, 'The Kerala-Einstein Study'. Our overall goals are: 1) develop sustained collaborations between US and Kerala researchers; 2) create a research network in Kerala building on existing research and clincial facilities; and 3) Show feasibility and generate preliminary data for future joint proposals to address age related cognitive and motor outcomes. Research capacity building activities include developing uniform diagnostic procedures, developing and validating culture fair instruments such as a picture-based memory impairment screen (Study 1), supporting research training, creating computerized databases, and exploring the feasibility of establishing brain banking. The prevalence of dementia in Kerala seniors is 1.3 to 5.3%. An increasing prevalence of cardiovascular disease has also been reported in Kerala. Cardiovascular risk factors, cerebrovascular disease, and dementia often coexist, but it is unclear if the relation between these problems is coincidental or causal. We propose to examine the role of cardiovascular disease as well as other risk factors (gait abnormalities, low education, and leisure activities) for dementia in Kerala seniors. Over the 2-year study period, we will examine these variables in a case control study in a clinic-based sample of 400 adults in Kozhikode (Study 2) as well as longitudinally in over 2000 older adults participating in an ongoing cohort study in Thiruvananthapuram (Study 3). The Kerala-Einstein study has the potential to have a major impact on future research and clinical practice in Kerala and USA, and will build the foundation for future long term studies of risk factors for age related cogitive and motor decline utilizing collaborative arrangements developed through this proposal. PUBLIC HEALTH RELEVANCE: This R21 grant is designed to foster collaborative research between US and Indian investigators to study risk factors, especially cardiovascualr diseases, for cognitive decline among older adults living in the Indian state of Kerala. Our research sites are in the cities of Kozhikode and Thiruvananthapuram in Kerala. We also propose to develop research infrastructure and train junior faculty to sustain future research efforts.

描述（由申请人提供）：此修订后的R21赠款旨在促进协作研究，以研究居住在喀拉拉邦印度州的老年人认知能力下降的危险因素。我们的研究地点是喀拉拉邦的Kozhikode和Thiruvananthapuram的城市。该提案将由阿尔伯特·爱因斯坦医学院的神经科医生Verghese博士与喀拉拉邦人，与Sri Chitra Tirunal Institute的行为神经病学部主任Mathuranath博士，Thiruvananthapuram的行为神经病学部主任，印度的Premier Premier医疗机构医疗机构和DREURAM ORDIT＆NEURAM ODERICE和NEURAM ODER，NEURAM ODER，NEURAM ODER，NEURAM OFFICE，NEURAM OFFICE，NEURAM ODER，NEURAM OFFICE，NEURAM OFFICE，NEURAM of a.我们的合作是“喀拉拉邦 - 因斯坦研究”。我们的总体目标是：1）我们与喀拉拉邦研究人员之间建立持续的合作； 2）在喀拉拉邦建立有关现有研究和clincial设施的研究网络； 3）显示可行性并生成初步数据，以解决未来的联合建议，以解决与年龄相关的认知和运动结果。研究能力建设活动包括制定统一的诊断程序，开发和验证文化公平工具，例如基于图片的记忆障碍屏幕（研究1），支持研究培训，创建计算机数据库以及探索建立大脑银行业务的可行性。喀拉拉邦老年人的痴呆症患病率为1.3％至5.3％。在喀拉拉邦，心血管疾病的患病率越来越多。心血管危险因素，脑血管疾病和痴呆症经常共存，但目前尚不清楚这些问题之间的关系是偶然的还是因果关系。我们建议研究喀拉拉邦老年人痴呆症的心血管疾病以及其他危险因素（步态异常，低教育和休闲活动）的作用。在两年的研究期内，我们将在案例对照研究中研究这些变量，该变量在基于Kozhikode的400名成年人（研究2）的基于诊所的样本中，以及2000多名老年人参与Thiruvananthapuram进行的一项正在进行的人群研究的纵向研究（研究3）。喀拉拉邦 - 因斯坦研究有可能对喀拉拉邦和美国的未来研究和临床实践产生重大影响，并将利用通过该提案开发的协作安排为未来的长期长期研究危险因素的长期研究奠定基础。公共卫生相关性：这项R21赠款旨在促进美国和印度调查人员之间的合作研究，以研究居住在喀拉拉邦印度州的老年人的认知能力下降，以研究危险因素，尤其是心血管疾病。我们的研究地点位于喀拉拉邦的Kozhikode和Thiruvananthapuram城市。我们还建议开发研究基础设施并培训初级教师以维持未来的研究工作。

项目成果

Cerebral Small Vessel Disease and Motoric Cognitive Risk Syndrome: Results from the Kerala-Einstein Study.

• DOI: 10.3233/jad-150523
• 发表时间: 2016
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Wang N;Allali G;Kesavadas C;Noone ML;Pradeep VG;Blumen HM;Verghese J
• 通讯作者: Verghese J

Response letter to Drs. Vidal, Villas Boas, Valle, and Fukushima.

给博士的回复信。

• DOI: 10.1111/jgs.12336
• 发表时间: 2013
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Verghese,Joe;Mathuranath,PavagadaS
• 通讯作者: Mathuranath,PavagadaS

A review of neuroimaging biomarkers of Alzheimer's disease.

阿尔茨海默病的神经影像生物标志物综述。

• 发表时间: 2013
• 期刊: Neurology Asia
• 影响因子: 0.2
• 作者: Varghese,Tinu;Sheelakumari,R;James,JijaS;Mathuranath,Ps
• 通讯作者: Mathuranath,Ps

Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits.

• DOI: 10.3174/ajnr.a5339
• 发表时间: 2017-10
• 期刊: AJNR. American journal of neuroradiology
• 作者: Sheelakumari R;Kesavadas C;Varghese T;Sreedharan RM;Thomas B;Verghese J;Mathuranath PS
• 通讯作者: Mathuranath PS

Microtubule-associated protein tau genetic variations are uncommon cause of frontotemporal dementia in south India.

• DOI: 10.1016/j.neurobiolaging.2013.08.010
• 发表时间: 2014-02
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Aswathy PM;Jairani PS;Verghese J;Gopala S;Mathuranath PS
• 通讯作者: Mathuranath PS