SERUM BILE ACID LEVEL IN PREGNANT WOMEN WITH AND WITHOUT HIV INFECTION

感染和未感染 HIV 的孕妇的血清胆汁酸水平

• 批准号: 7605096
• 负责人: ADRIANA WEINBERG
• 金额: $ 12.46万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605096
• 关键词: Affect; Anti-Retroviral Agents; Bile Acids; Biochemical; Birth; Blood Vessels; Characteristics; Cholestasis; Clinical; Computer Retrieval of Information on Scientific Projects Database; Condition; Discipline of obstetrics; Elevation; Funding; Grant; Hepatitis C; Infection; Institution; Liver diseases; Patients; Pharmaceutical Preparations; Placental Insufficiency; Pregnancy; Pregnancy Trimesters; Pregnant Women; Research; Research Personnel; Resources; Retrospective Studies; Risk; Serum; Source; Umbilical Cord Blood; United States National Institutes of Health; Woman; fetal; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serum bile acid elevations during pregnancy are associated with obstetric cholestasis (OC), which carries significant risks of fetal demise and other complications. These are a consequence of bile acid-induced vascular placental insufficiency. OC is more common in patients with underlying liver disease (hepatitis C infection). HIV-infected women are subject to heptatotoxic agents that might increase the risk of OC. To determine if HIV-infected women have increased serum bile acid levels during pregnancy, we will compare serum bile acid levels during the 2nd and 3rd trimesters of pregnancy and in the cord blood of 40 HIV-infected, 10 Hep C-infected, and 10 uninfected pregnant women. We will identify associations between serum bile acid levels and birth conditions of the neonate. We will determine if antiretroviral medication affects bile acid levels by comparing the decrease between last month of pregnancy and post-partum in HIV-infected pregnant women who continue on therapy vs. other subjects. We will also conduct a retrospective study of OC at UCHSC to identify potential similarities between the clinical and biochemical findings associated with bile acid levels in HIV-infected pregnant women and the clinical, biochemical, and epidemiological characteristics of OC in normal pregnancy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 怀孕期间的血清胆汁酸升高与产科胆汁淤积（OC）有关，该胆汁淤积物具有胎儿灭亡和其他并发症的重大风险。这些是胆汁酸引起的血管胎盘功能不全的结果。 OC在潜在的肝病患者（乙型肝炎感染）中更为常见。感染HIV的妇女受到七毒剂的影响，可能会增加OC的风险。为了确定妊娠期间感染HIV的妇女是否具有升高的血清胆汁酸水平，我们将比较妊娠的第二和第三个三物种以及40例HIV感染的脐带血，10 HEP C感染，10个HEP C感染和10名未感染的孕妇。我们将确定血清胆汁酸水平与新生儿的出生状况之间的关联。我们将通过比较继续接受治疗与其他受试者的HIV感染孕妇与其他受试者的艾滋病毒感染孕妇的妊娠和产后下个月之间的减少来确定抗逆转录病毒药物是否会影响胆汁酸水平。我们还将对UCHSC的OC进行回顾性研究，以确定与HIV感染的孕妇中与胆汁酸水平相关的临床和生化发现之间的潜在相似性，以及正常妊娠中OC的临床，生化和流行病学特征。