Psychopathology in Pharmacotherapy of AUD/MDD Teens

AUD/MDD 青少年药物治疗中的精神病理学

基本信息

批准号：
7561651
负责人：
JACK R CORNELIUS
金额：
$ 12.04万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-02-10 至 2011-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7561651
关键词：
Acute Address Adolescent Adult Aftercare Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohols Antidepressive Agents Area Award Back Child Clinical Clinical Research Clinical Trials Cognitive Therapy Development Diagnosis Double-Blind Method Fluoxetine Frequencies Funding Goals Hamilton Rating Scale for Depression Knowledge Major Depressive Disorder Measures Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Motivation Nature Outcome Pharmaceutical Preparations Pharmacotherapy Phase Pilot Projects Placebo Effect Placebos Population Psychopathology Relapse Research Research Personnel Sampling Selective Serotonin Reuptake Inhibitor Specific qualifier value Substance Use Disorder Techniques Teenagers Therapeutic Effect Time TimeLine Training United States Food and Drug Administration Work adolescents with alcohol use disorders alcohol abuse therapy alcohol use disorder base career career development depressed depression depressive symptoms drinking follow up assessment impression open label patient oriented research placebo controlled study problem drinker prospective treatment as usual underage drinking

项目摘要

DESCRIPTION (provided by applicant): Clinical trials and clinical mentoring involving studies of adolescents with alcohol use disorders (AUD) lag considerably behind those for adults. This proposal for a Mid-Career Investigator Award in Patient-Oriented Research describes a career plan in patient-oriented research, mentorship, and career development in the area of clinical trials involving adolescents with AUD and comorbid major depression (MDD). The applicant has previously demonstrated expertise in conducting pharmacotherapy studies involving adults with comorbid AUD/MDD. The Career Development portion of this proposed award will seek to extend the applicant's ability to optimally conduct and interpret pharmacotherapy studies to those involving adolescent AUD populations. This goal would be accomplished by strengthening the applicant's background in developmental psychopathology and specified advanced statistical techniques. This training would make the applicant a more effective mentor for trainees working with this important but understudied population. This work would also enhance the applicant's knowledge of the relationship between clinical improvements in depressive symptoms and alcohol use among comorbid AUD/MDD adolescents during treatment. The clinical study proposed in this K24 award is associated with a double-blind, placebo-controlled study involving fluoxetine in adolescents with comorbid AUD/MDD (R01 AA13370), now in its third year. Research proposed in this application seeks to extend this funded work with adolescents by elucidating the nature of the relationship between improvement both in drinking and in depressive symptoms. This award would allow the applicant to curtail various clinical, administrative, and research duties in order to focus on adolescent populations with AUD. The largest part of the career plan is the mentoring of trainees in patient-oriented research involving adolescents with AUD. This will not only benefit the applicant's educational development, but will also address the paucity of researchers in this area.

描述（由申请人提供）：临床试验和临床指导，涉及对酒精使用障碍的青少年的研究（AUD）落后于成年人。这项针对以患者为导向的研究的中级研究员奖提出的提案描述了涉及AUD和合并症大抑郁症（MDD）的青少年的临床试验领域的职业计划，指导和职业发展。申请人先前已经证明了在进行涉及合并AUD/MDD的成年人的药物治疗研究方面具有专业知识。拟议奖项的职业发展部分将寻求将申请人最佳地进行和解释药物疗法研究的能力扩展到涉及青少年AUD人群的人。该目标将通过加强申请人在发育心理病理学方面的背景和指定的高级统计技术来实现。这项培训将使申请人成为与这个重要但经过研究的人群一起工作的学员更有效的导师。这项工作还将增强申请人对抑郁症状的临床改善与在治疗过程中合并的AUD/MDD青少年之间使用之间的关系的了解。该K24奖中提出的临床研究与涉及氟西汀的双盲，安慰剂对照研究有关，该研究目前已进入第三年，涉及合并AUD/MDD（R01 AA13370）的青少年（R01 AA13370）。本申请中提出的研究旨在通过阐明饮酒和抑郁症状改善之间关系的性质来扩展与青少年的资助。该奖项将使申请人能够削弱各种临床，行政和研究职责，以便专注于AUD的青春期人群。职业计划中最大的部分是在涉及AUD的青少年的以患者为导向的研究中指导受训者。这不仅将使申请人的教育发展受益，而且还将解决该领域研究人员的匮乏。