Quantitative Cardiac PET/CT Imaging

定量心脏 PET/CT 成像

• 批准号: 7578264
• 负责人: Adam M Alessio
• 金额: $ 11.13万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7578264
• 关键词: Address; Algorithms; Anatomy; Angiography; Arts; Biomedical Engineering; Blood flow; Cardiac; Cardiology; Cardiovascular Physiology; Cardiovascular system; Clinical; Clinical Protocols; Complement; Coronary; Coronary Arteriosclerosis; Coronary heart disease; Data; Detection; Development; Diagnosis; Diagnostic; Discipline of Nuclear Medicine; Disease; Dose; Ensure; Environment; Event; Faculty; Generations; Image; Imaging Techniques; Ischemia; Lead; Measurement; Mentors; Metabolism; Methods; Modeling; Morphologic artifacts; Motion; Movement; Myocardial; Myocardial perfusion; Needs Assessment; Noise; Nuclear; Patients; Phase; Photons; Physics; Positron-Emission Tomography; Procedures; Property; Protocols documentation; Radiology Specialty; Research; Research Personnel; Resolution; Role; Solutions; System; Techniques; Tissue Viability; Tomography, Computed, Scanners; Tracer; Training; Training Activity; Universities; Washington; X-Ray Computed Tomography; attenuation; base; bioimaging; career; design; experience; heart imaging; heart motion; image processing; image reconstruction; imaging modality; improved; insight; member; millisecond; programs; reconstruction; respiratory; statistics; uptake

DESCRIPTION (provided by applicant): Positron emission tomography (PET) combined with computed tomography (CT) in an integrated PET/CT scanner offers a single-study, noninvasive technique for the diagnosis of coronary artery disease. PET/CT cardiac scans can provide complementary functional and anatomic assessments: PET can quantitate myocardial perfusion and metabolism offering insight into small vessel disease and tissue viability; while contrast enhanced CT angiography provides information on coronary anatomy and atherosclerotic burden. PET offers the potential for truly quantitative measurements, but this quantitation is confounded by (1) misaligned CT-based attenuation correction (CTAC) factors and (2) the limited sensitivity of PET imaging. Respiratory motion, cardiac motion, and/or patient movement cause misalignment between the CTAC image and the PET image. To reduce this misalignment, Aim 1 develops and evaluates CT acquisition protocols tailored for attenuation correction in cardiac PET imaging to improve qualitative and quantitative accuracy. The limited sensitivity of PET imaging results in noisy dynamic studies and requires image acquisitions over multiple respiratory and cardiac cycles. Aim 2 investigates methods to reduce these degradations with reconstruction methods tailored for myocardial blood flow estimation in cardiac PET imaging. This research plan complements a comprehensive training plan to facilitate Dr. Alessio's development as a bioimaging researcher and junior faculty member in the Department of Radiology at the University of Washington. Dr. Alessio's previous research has focused on statistical image processing and tomographic reconstruction. The proposed training plan including mentoring, biomedical coursework, and scholarly activities will allow him to transition into a biomedical role and solve pressing clinical problems in cardiac imaging. The mentors for this proposal represent several decades of experience - James Caldwell and James Bassingthwaighte for cardiovascular function and modeling and Thomas Lewellen and Paul Kinahan for nuclear medicine physics, image generation, and clinical protocol optimization. The University of Washington, with its internationally recognized programs in cardiovascular bioengineering, nuclear cardiology, and diagnostic physics, is an ideal environment for the development of an independent research career combining state of the art imaging techniques with clinical needs for the assessment of coronary disease. This development will occur while contributing solutions to what are widely recognized as the most important challenges in cardiac PET/CT imaging.

描述（由申请人提供）：正电子发射断层扫描（PET）与综合PET/CT扫描仪中计算机断层扫描（CT）结合使用，提供了一种单个研究，无创的技术，用于诊断冠状动脉疾病。 PET/CT心脏扫描可以提供互补的功能和解剖学评估：PET可以定量心肌灌注和代谢，从而深入了解小血管疾病和组织生存能力；尽管对比增强了CT血管造影，可提供有关冠状动脉解剖结构和动脉粥样硬化负担的信息。 PET提供了真正定量测量的潜力，但是此定量与（1）基于CT未对准的衰减校正（CTAC）因子（CTAC）因子和（2）PET成像的敏感性有限。呼吸运动，心脏运动和/或患者运动导致CTAC图像和PET图像之间的错位。为了减少这种错位，AIM 1开发并评估了针对心脏宠物成像衰减校正的CT采集方案，以提高定性和定量准确性。 PET成像的有限敏感性导致嘈杂的动态研究，并且需要对多个呼吸和心脏周期进行图像采集。 AIM 2研究了针对心脏宠物成像中心肌血流估计的重建方法减少这些降解的方法。该研究计划补充了一项全面的培训计划，以促进Alessio博士作为华盛顿大学放射学系的生物成像研究人员和初级教师的发展。 Alessio博士先前的研究重点是统计图像处理和层析成像重建。拟议的培训计划，包括指导，生物医学课程和学术活动，将使他能够过渡到生物医学角色，并解决心脏成像中的临床问题。该提案的导师代表了数十年的经验 - 詹姆斯·考德威尔（James Caldwell）和詹姆斯·巴斯（James Bassingthwaighte）的心血管功能和建模以及托马斯·莱沃伦（Thomas Lewellen）和保罗·基纳汉（Paul Kinahan）以及核医学物理学，图像生成和临床方案优化。华盛顿大学及其在心血管生物工程，核心脏病学和诊断物理学方面具有国际认可的计划，是建立独立研究职业的理想环境，结合了艺术成像技术及其临床需求，以评估冠状动脉疾病。这种发展将在为心脏宠物/CT成像中最重要的挑战中贡献解决方案时发生。