MR Guided Focused Ultrasound Surgery

MR 引导聚焦超声手术

基本信息

批准号：
7255003
负责人：
Kullervo Hynynen
金额：
$ 19.8万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7255003
关键词：
Animal Experiments Animal Model Breast Canis familiaris Clinical Clinical Trials Coagulation Process Computer Simulation Data Dose Electronics Feedback Focused Ultrasound Therapy Funding Healthcare Hemorrhage Infection Invasive Magnetic Resonance Imaging Malignant neoplasm of prostate Methods Modeling Monitor Operative Surgical Procedures Outpatients Phase Procedures Prostate Prostatic Diseases Prostatic Neoplasms Rate Recovery Research Risk Safety Sonication Staging System Technology Temperature Testing Thermometry Time Tissues Ultrasonography United States Food and Drug Administration Uterine Fibroids base breast fibroadenoma cost in vivo malignant breast neoplasm pre-clinical prostate surgery research study simulation tissue phantom treatment planning two-dimensional

Animal Experiments Animal Model Breast Canis familiaris Clinical Clinical Trials Coagulation Process Computer Simulation Data Dose Electronics Feedback Focused Ultrasound Therapy Funding Healthcare Hemorrhage Infection Invasive Magnetic Resonance Imaging Malignant neoplasm of prostate Methods Modeling Monitor Operative Surgical Procedures Outpatients Phase Procedures Prostate Prostatic Diseases Prostatic Neoplasms Rate Recovery Research Risk Safety Sonication Staging System Technology Temperature Testing Thermometry Time Tissues Ultrasonography United States Food and Drug Administration Uterine Fibroids base breast fibroadenoma cost in vivo malignant breast neoplasm pre-clinical prostate surgery research study simulation tissue phantom treatment planning two-dimensional

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项目摘要

During the current funded period of this research, we have successfully implemented MRI-based thermometry for the monitoring of focused ultrasound treatments. We have used MRI-based thermometry to determine the threshold thermal dose for tissue damage during short sonications, and we have demonstrated its usefulness in a clinical setting in treatments of breast fibroadenomas, breast cancer, and uterine fibroids. We have also developed methods for treatment planning and shown the impact of wavefront distortion by overlying tissues. Based on these results, we propose to further this research by testing the following hypothesis: Intracavitary ultrasound phased arrays can be used to effectively coagulate prostate tumors when MRI temperature monitoring is used. To test this hypothesis we will first, explore the feasibility of using intracavitary focused ultrasound phased arrays with MRI monitoring by developing a linear array system for minimally invasive ultrasound surgery of early stage prostate cancer and performing pre-clinical tests of it in an animal model. Second, we will explore methods to use MRI derived temperature information to control the treatment so that the coagulation of the complete target volume can be accomplished. Finally, we will develop full-scale two-dimensional transrectal arrays that will exploit the full potential of phased array ultrasound technology for the treatment of prostate disease. At the close of this research we will have developed the necessary methods for clinical feasibility testing of a precise and monitored thermal coagulation method for prostate cancer that can reduce both the treatment time and the impotency rate. This procedure may replace current open surgery with a method that could potentially be performed on outpatient basis and is much less invasive. The healthcare benefits of the proposed treatments are significant and include faster recovery, reduced cost, and a lowered risk of infection and bleeding

在本研究的当前资助期间，我们成功地实施了基于MRI的用于监测聚焦超声处理的温度计。我们已经使用基于MRI的热法确定在短超声音期间组织损伤的阈值热剂量，我们有在乳腺纤维纤维瘤，乳腺癌和子宫肌瘤。我们还开发了治疗计划的方法，并显示了波前的影响通过覆盖组织的变形。基于这些结果，我们建议通过测试以下假设：卫星内超声段阵列可用于有效凝结前列腺使用MRI温度监测时的肿瘤。为了检验这一假设，我们将首先探索可行性通过开发线性阵列，使用带有腔内聚焦的超声段阵列和MRI监测早期前列腺癌的最小侵入性超声手术的系统并进行临床前进行在动物模型中对其进行测试。其次，我们将探索使用MRI派生温度信息的方法为了控制治疗，以便可以完成完整目标体积的凝结。最后，我们将开发全尺度的二维转直肠阵列，这些阵列将利用分阶段阵列的全部潜力用于治疗前列腺疾病的超声技术。在这项研究结束时，我们将拥有开发了精确和监测热的临床可行性测试的必要方法前列腺癌的凝结方法可以降低治疗时间和阳ot的率。这手术可以用一种可能在门诊病人上执行的方法代替当前的开放手术基础，侵入性要小得多。拟议治疗的医疗保健益处很重要，并且包括更快的恢复速度，降低的成本以及降低感染风险和出血的风险