Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight

膳食乳制品的最佳水平对调节青少年体重的功效

基本信息

  • 批准号:
    7462042
  • 负责人:
  • 金额:
    $ 43.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-04-01 至 2013-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Childhood and adolescent obesity is epidemic in the US, and the incidence is increasing. This is of concern because childhood obesity tracks into adulthood and is associated with higher rates of adult obesity and related co-morbidity. Adolescence is a critical period for the development of overweight, especially for girls. Also, on average, girls in the US have sub-optimal calcium intakes. Strong evidence supports the efficacy of a diet high in calcium, particularly in dairy food, in preventing overweight and facilitating weight loss in adults. Although observational studies suggest that calcium modulates weight in children, there are no published reports of randomized, controlled trials of the effect of dairy foods on weight/body fat (BF) in children or adolescents. The goal of the proposed research is to determine if increasing intake of dairy foods to recommended levels in adolescent females with habitually low calcium intake will decrease BF gain compared to similar females who continue their low calcium intake. We propose a 1-year intervention in 13- and 14-year old girls who are above the 50th percentile for body mass index (BMI) and are at least 1= years post- menarche to determine if we can prevent excessive BF gain. The hypothesis is: Post-menarcheal adolescent girls with habitually low calcium intake who consume dairy foods providing at least 1200 mg of calcium/day will have a smaller increase in percent BF during 1 year than post-menarcheal adolescent girls on a usual diet of 600 mg of calcium/day or less. We will recruit 321 healthy girls and conduct a 2-week run-in to assess their ability to tolerate a high dairy diet. We will enroll 274 eligible girls and randomly assign them, stratified by BMI- percentile (percentile), to a high dairy diet or their usual diet. Exclusion criteria include: total body bone mineral content (TBBMC) Z score <-2; pregnancy, lactose intolerance, early menarche, or any health problem. Girls > 85th percentile of BMI will be eligible only with approval of their personal physician. At 6-month intervals we will assess percent body fat, TBBMC, Tanner stage, height, weight, waist circumference, and abdominal girth. Dietary intake and physical activity will be assessed quarterly. The proposed study directly relates to the NINR Mission to prevent disease. Positive findings from this study will result in a safe, inexpensive nutritional method of preventing overweight and the related co-morbidity in adolescent girls. This may decrease their risk of adult obesity and will provide support for further studies in male adolescents and in younger children. PUBLIC HEALTH RELEVANCE: The purpose of this project is to determine if increasing intake of dairy foods to currently recommended levels (4 servings per day) in adolescent girls will decrease the risk of their becoming overweight. Positive findings from this study will form the basis for the future development of a safe, inexpensive, health-promoting method of preventing overweight in adolescent girls and provides the rationale for future studies in adolescent boys and in younger children. Such a dairy intervention would be congruent with currently recommended calcium and dairy intake.
描述(由申请人提供):在美国,儿童和青少年肥胖是流行的,发病率正在增加。这是令人关注的,因为儿童肥胖迹象到成年,并且与成人肥胖和相关合并症的率更高有关。青春期是超重发展的关键时期,尤其是对于女孩而言。而且,平均而言,美国的女孩具有亚最佳的钙摄入量。有力的证据支持高钙的饮食功效,尤其是乳制品,以防止成人超重和促进体重减轻。尽管观察性研究表明,钙调节儿童的体重,但尚无关于乳制品对儿童或青少年体重/体重(BF)影响的随机,对照试验的公开报告。拟议的研究的目的是确定与继续低钙摄入量低的类似女性相比,习惯性较低的钙摄入量的青少年女性中乳制品的摄入量是否增加对习惯性较低的钙摄入量的推荐水平是否会降低BF的增长。我们建议对13岁和14岁的女孩进行一年的干预,这些女孩高于体重指数(BMI)的第50个百分点,至少是一级后期1 =一年,以确定我们是否可以防止过多的BF增益。假设是:年龄较低的青春期女孩的习惯性较低的钙摄入量,他们在1年中食用至少1200毫克钙/天的乳制品含量至少增加了BF百分比的增长,而年龄较大后的青少年女孩通常以600毫克的钙/天或更少。我们将招募321名健康女孩,并进行为期2周的跑步,以评估她们耐受高乳制品饮食的能力。我们将注册274名合格的女孩,并将其随机分配,并通过Bmi-Patishile(百分位数)分层,以高乳制品饮食或通常的饮食。排除标准包括:总体骨矿物质含量(TBBMC)z评分<-2;怀孕,乳糖不耐症,初潮或任何健康问题。只有在私人医师的批准下,女孩> BMI的第85个百分点才有资格。在6个月的间隔中,我们将评估体内脂肪,TBBMC,Tanner阶段,身高,体重,腰围和腹肌的百分比。饮食摄入和体育锻炼将每季度评估。拟议的研究直接涉及预防疾病的NINR任务。这项研究的积极发现将导致一种安全,廉价的营养方法,以防止青少年女孩超重和相关的合并症。这可能会降低其成人肥胖的风险,并将为在男性青少年和年幼儿童中的进一步研究提供支持。 公共卫生相关性:该项目的目的是确定将乳制品摄入到当前推荐的水平(每天4份)中是否会降低其超重的风险。这项研究的积极发现将构成未来开发一种安全,廉价,促进健康的方法,以防止青少年女孩超重,并为未来的青少年男孩和年幼的孩子提供理由。这种乳制干预将与当前推荐的钙和乳制品摄入量相一致。

项目成果

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JOAN LAPPE其他文献

JOAN LAPPE的其他文献

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{{ truncateString('JOAN LAPPE', 18)}}的其他基金

Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
维生素 D3 降低绝经后妇女癌症风险的临床试验
  • 批准号:
    8197063
  • 财政年份:
    2009
  • 资助金额:
    $ 43.93万
  • 项目类别:
Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
维生素 D3 降低绝经后妇女癌症风险的临床试验
  • 批准号:
    7810241
  • 财政年份:
    2009
  • 资助金额:
    $ 43.93万
  • 项目类别:
Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
维生素 D3 降低绝经后妇女癌症风险的临床试验
  • 批准号:
    8391272
  • 财政年份:
    2009
  • 资助金额:
    $ 43.93万
  • 项目类别:
Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
维生素 D3 降低绝经后妇女癌症风险的临床试验
  • 批准号:
    7753215
  • 财政年份:
    2009
  • 资助金额:
    $ 43.93万
  • 项目类别:
Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
维生素 D3 降低绝经后妇女癌症风险的临床试验
  • 批准号:
    8026866
  • 财政年份:
    2009
  • 资助金额:
    $ 43.93万
  • 项目类别:
Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
维生素 D3 降低绝经后妇女癌症风险的临床试验
  • 批准号:
    7580381
  • 财政年份:
    2009
  • 资助金额:
    $ 43.93万
  • 项目类别:
Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
膳食乳制品的最佳水平对调节青少年体重的功效
  • 批准号:
    8054778
  • 财政年份:
    2008
  • 资助金额:
    $ 43.93万
  • 项目类别:
Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
膳食乳制品的最佳水平对调节青少年体重的功效
  • 批准号:
    8247000
  • 财政年份:
    2008
  • 资助金额:
    $ 43.93万
  • 项目类别:
Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
膳食乳制品的最佳水平对调节青少年体重的功效
  • 批准号:
    7800465
  • 财政年份:
    2008
  • 资助金额:
    $ 43.93万
  • 项目类别:
Efficacy of Optimal Levels of Dietary Dairy on Modulation of Adolescent Weight
膳食乳制品的最佳水平对调节青少年体重的功效
  • 批准号:
    7597204
  • 财政年份:
    2008
  • 资助金额:
    $ 43.93万
  • 项目类别:

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