Fast Targeted Spectroscopic Imaging for Brain Tumor Imaging at 3T and 7T

用于 3T 和 7T 脑肿瘤成像的快速靶向光谱成像

基本信息

批准号：
9767810
负责人：
Hoby P Hetherington
金额：
$ 44.57万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9767810
关键词：
3-Dimensional Acceleration Address Brain Brain Chemistry Brain Neoplasms Brain imaging Brain region Chemicals Childhood Glioma Choline Clinical Clinical Management Complement Complex Data Development Diagnosis Diagnostic Diffusion Dimensions Epilepsy Evaluation Glioblastoma Goals Image Immune response Immunotherapeutic agent Immunotherapy Inositol Lipids Location Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurement Measures Medical Metabolic Methods Monitor Morphologic artifacts Multiple Sclerosis Nature Operative Surgical Procedures Patients Performance Physiologic pulse Physiology Process Property Recovery Recurrence Regimen Relaxation Research Personnel Resolution Sampling Scanning Slice Therapeutic Time Tissues Translating Traumatic Brain Injury Update Water Work anatomic imaging base cancer imaging chemoradiation clinical application clinically relevant contrast enhanced cost effective therapy experience follow-up imaging approach imaging modality imaging study improved ineffective therapies magnetic field magnetic resonance spectroscopic imaging neuro-oncology novel therapeutic intervention premature preservation research clinical testing response spectroscopic imaging success treatment effect treatment response tumor tumor metabolism tumor progression two-dimensional

项目摘要

Magnetic Resonance Spectroscopic Imaging (MRSI) has proven to provide unique information for the diagnosis and management of brain tumors, epilepsy, multiple sclerosis and traumatic brain injury. Despite the obvious advantage of imaging approaches over single volume measurements, clinically, most MRS studies are still performed as single voxel studies. The reluctance to include MRSI in clinical evaluations arises primarily from four factors: 1) increased acquisition times; 2) limitations in spectral quality when data is acquired over larger brain regions; 3) limitations in SNR and 4) challenges in sampling the cortical periphery. To overcome these limitations we will develop a fast MRSI method (5-10min.) which uses: 1) two dimensional rosette encoding trajectories to rapidly sample the brain in two dimensions while minimizing gradient demands and improve spectral quality; 2) Hadamard encoding in the third dimension to minimize localization artifacts and provide excellent slice profiles for smaller numbers of partitions (4-8) covering the most relevant brain region; 3) a high degree shim insert to maximize magnetic field homogeneity and improve spectral quality and 4) dynamic spatially selective dephasing to maximize SNR and sample the cortical periphery. Consistent with what is the most widely accepted MRS clinical application currently, we will evaluate the methods in patients with high-grade brain tumors receiving immunotherapy. Although immunotherapy is a highly promising new therapeutic approach for brain tumors, treatment effects can mimic tumor progression on conventional MRI, compromising our ability to effectively monitor and manage these patients. MRSI offers an alternative means to monitor progression, based on tumor metabolism and physiology as opposed to relaxation properties of tissue water (conventional MRI). Thus we believe that MRSI may provide additive values and significantly aid in the management of these patients. This work will be performed at 3T and 7T.

磁共振波谱成像 (MRSI) 已被证明可以提供独特的信息脑肿瘤、癫痫、多发性硬化症和脑外伤的诊断和治疗。尽管与单体积测量相比，成像方法具有明显的优势，临床上大多数 MRS 研究都是仍然作为单个体素研究进行。不愿将 MRSI 纳入临床评估的主要原因是来自四个因素：1）采集次数增加； 2) 采集数据时光谱质量的限制更大的大脑区域； 3) 信噪比的限制和 4) 皮质外围采样的挑战。克服针对这些限制，我们将开发一种快速 MRSI 方法（5-10 分钟），该方法使用：1) 二维玫瑰花结编码轨迹以在二维上快速采样大脑，同时最大限度地减少梯度需求提高光谱质量； 2）三维Hadamard编码以最小化定位伪影和为覆盖最相关的大脑区域的较少数量的分区（4-8）提供出色的切片轮廓； 3) 高度匀场插件可最大限度地提高磁场均匀性并提高光谱质量 4) 动态空间选择性相移以最大化信噪比并对皮质外围进行采样。符合目前最广泛接受的MRS临床应用是什么，我们将在患者中评估这些方法接受免疫治疗的高级脑肿瘤。尽管免疫疗法是一种非常有前途的新疗法脑肿瘤的治疗方法，治疗效果可以模拟传统 MRI 上的肿瘤进展，损害我们有效监测和管理这些患者的能力。 MRSI 提供了另一种方法根据肿瘤代谢和生理学而不是组织的松弛特性来监测进展水（传统 MRI）。因此，我们相信 MRSI 可以提供附加值并显着帮助对这些患者的管理。这项工作将在 3T 和 7T 进行。