Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student

生物力学力暴露对认知的影响

基本信息

批准号：
7680999
负责人：
Thomas McAllister
金额：
$ 29.97万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7680999
关键词：
Effect Biomechanical Force Exposure Cognition

项目摘要

DESCRIPTION (provided by applicant): 300,000 individuals sustain sports concussions each year in the U.S. The majority of at-risk athletes are at the high school level. High school football players represent a particularly high-risk group, accounting for about two-thirds of all concussions in high school athletes. The short- and long-term effects of sports concussions and perhaps more importantly repetitive sub-concussive impacts are not known, nor are the cumulative effects of repeated injuries understood. There is enormous variability in outcome, although the reasons for this variability are not understood. We propose to use technological advances in on-field head impact monitoring, cognitive testing, and functional brain imaging to learn for the first time what types of head impacts, under what circumstances, in which individuals, cause what effects in brain function. This proposal will help to determine the short and long term effects of repetitive biomechanical force exposure on the developing adolescent brain, provide important information on the biomechanics of sports-related traumatic brain injury, and lead to more informed return-to-play guidelines. The overarching theme of this proposal is that a youth's exposure to biomechanical forces is a critical factor influencing cognitive outcome. This has two broad components: the characteristics of a single impact (e.g. linear acceleration, rotational acceleration, direction etc.), and the history of exposure to biomechanical forces over time (e.g. measures of frequency and intensity of impacts over the preceding days and weeks). We propose to use technological advances in on-field head impact monitoring, cognitive testing, and functional brain imaging to learn for the first time what types of head impacts, under what circumstances, in which individuals, cause what effects in brain function. Exposure to biomechanical forces acutely (post-concussive), sub-acutely (pre- to one-month post-season), and cumulatively (exposure over multiple seasons of play) are of interest and will be monitored. Two groups of high school student athletes (football players and non-impact sport athletes) will be studied at three time points (preseason, after a single season of play, and after multiple seasons of play) using a standardized cognitive battery and functional MRI (fMRI). A subgroup of students who sustain concussion, and matched controls from their team and from the non-impact athlete group will also be studied within one week of the concussion. Impact parameters will be directly measured using helmet-based accelerometer units.

描述（由申请人提供）：美国每年有 300,000 人遭受运动脑震荡。大多数高危运动员都是高中生。高中橄榄球运动员是一个特别高危的群体，约占所有高中运动员脑震荡的三分之二。运动脑震荡的短期和长期影响以及也许更重要的是重复性亚脑震荡影响尚不清楚，也不了解重复伤害的累积影响。结果存在巨大的可变性，尽管这种可变性的原因尚不清楚。我们建议利用现场头部撞击监测、认知测试和功能性脑成像方面的技术进步，首次了解什么类型的头部撞击、在什么情况下、在什么人的情况下会对大脑功能产生什么影响。该提案将有助于确定重复的生物力学力暴露对发育中的青少年大脑的短期和长期影响，提供有关运动相关创伤性脑损伤的生物力学的重要信息，并产生更明智的重返比赛指南。该提案的首要主题是，青少年接触生物力学力量是影响认知结果的关键因素。这有两个广泛的组成部分：单次冲击的特征（例如线性加速度、旋转加速度、方向等），以及随着时间的推移暴露于生物力学力的历史（例如前几天和几周内冲击的频率和强度的测量））。我们建议利用现场头部撞击监测、认知测试和功能性脑成像方面的技术进步，首次了解什么类型的头部撞击、在什么情况下、在什么人的情况下会对大脑功能产生什么影响。急性（脑震荡后）、亚急性（赛季前至一个月后）和累积（多个赛季的暴露）生物力学力的暴露是令人感兴趣的，并将受到监测。将使用标准化认知电池和功能 MRI 在三个时间点（季前赛、单个赛季比赛后和多个赛季比赛后）对两组高中生运动员（橄榄球运动员和非冲击运动运动员）进行研究。功能磁共振成像）。遭受脑震荡的学生小组以及来自其团队和非冲击运动员组的匹配对照也将在脑震荡发生后一周内进行研究。冲击参数将使用基于头盔的加速度计单元直接测量。