Strategies for Providing Antiretroviral Therapy to Infants Shortly After Primary

小学毕业后不久为婴儿提供抗逆转录病毒治疗的策​​略

• 批准号: 7679030
• 负责人: Avy Violari
• 金额: $ 123.48万
• 依托单位: WITS HEALTH CONSORTIUM (PTY), LTD
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7679030
• 关键词: Cessation of life; Child; Clinical; Disease Progression; End Point; Failure; HIV; Immune System Diseases; Infant; Life; Randomized; Time; Toxic effect; Treatment Protocols; Upper arm; antiretroviral therapy; improved; outcome forecast

The overall aim is to evaluate whether early therapy given for a limited time will improve HIV prognosis in the longer term by deferring the time that children need to start life-long ART. The primary objective compares time to failure of first line ART (due to clinical or immunological disease progression, or regimen-limiting ART toxicities) or death among three randomized arms (infants who receive early ART for a limited time in Arms 2 and 3 and infants in whom ART is deferred until clinical or immunological disease progression in Arm 1); the primary endpoint is time taken to reach the objective.

总体目的是评估有限时间进行的早期治疗是否会改善HIV的预后 长期通过推迟儿童开始终身艺术的时间。 主要客观将时间与第一线艺术的失败进行比较（由于临床或免疫疾病而导致 三个随机臂的进展或限制艺术毒性）或死亡（接受的婴儿 在武器2和3中有限时间的早期艺术和将艺术推迟到临床或 ARM 1中的免疫疾病进展；主要终点是达到目标的时间。