IMMUNO-VIROLOGICAL AND SAMPLE REPOSITORY SIV-INFECTED AND UNINFECTED MANGABEYS

感染和未感染白眉猴的免疫病毒学和样本库

• 批准号: 7562668
• 负责人: Guido Silvestri
• 金额: $ 5.24万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562668
• 关键词: Animals; Cercocebus; Cercocebus atys; Classification; Computer Retrieval of Information on Scientific Projects Database; Data; Data Set; Equilibrium; Evaluation; Freezing; Funding; Grant; Health Status; Infection; Institution; Plasma; Process; Publications; Research; Research Personnel; Research Project Grants; Resources; SIV; Sampling; Source; Surveys; United States National Institutes of Health; cohort; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This management study treats Yerkes' colonies of SIV-infected and uninfected sooty mangabeys as cohorts for which a periodic immuno-virological evaluation is conducted and a repository of frozen samples of plasma and PBMCs are stored and made available for selected research projects to both Yerkes and non-Yerkes investigators. An extensive survey of the Yerkes SMs was first completed in 2004 and is now being repeated. To date, we have collected and processed 100 samples during 2006 and will complete the balance of the colony shortly. The samples utilized from this project have been instrumental to several important publications in the field, as listed below. This general approach should also enable us to generate a set of immunological and virological data to conduct a systematic longitudinal assessment of the animals' health status, with specific focus on the course of SIV infection. This set of data will also allow the rapid and effective identification of SM with specific immunological and/or virological features.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项管理研究将Yerkes的SIV感染和未感染的烟灰芒果菌落视为同类的同类，进行了定期的免疫病毒学评估，并存储了血浆和PBMC的冷冻样品的存储库，并为Yerkes和非贝克斯的研究项目提供了可选的研究项目。 对Yerkes SMS的广泛调查于2004年首次完成，现在正在重复进行。 迄今为止，我们在2006年收集并处理了100个样本，并将尽快完成殖民地的余额。 从该项目中使用的样品对该领域的几个重要出版物有用，如下所述。 这种一般方法还应使我们能够生成一组免疫学和病毒学数据，以对动物的健康状况进行系统的纵向评估，并具体侧重于SIV感染过程。 这组数据还将允许具有特定免疫学和/或病毒学特征的SM快速有效识别。