BABOON MODEL FOR THE GENETICS OF CHAGAS DISEASE

恰加斯病遗传学的狒狒模型

• 批准号: 7562415
• 负责人: Jeff Williams
• 金额: $ 1.58万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562415
• 关键词: Biomedical Research; Blood; Cardiac; Cardiovascular system; Cessation of life; Chagas Disease; Computer Retrieval of Information on Scientific Projects Database; Disease; Endemic Diseases; Foundations; Funding; Genetic; Genetic Models; Grant; Heart Diseases; Human; Infection prevention; Insect Vectors; Institution; Latin America; Malaria; Papio; Parasites; Peripheral Nervous System; Persons; Pharmacotherapy; Primates; Public Health; Research; Research Personnel; Resources; Risk; Safety; Schistosomiasis; Source; South America; Study models; Symptoms; Tissue Banks; Tropical Disease; Trypanosoma cruzi; United States; United States National Institutes of Health; Vaccines; gastrointestinal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chagas disease is a zoonotic disease endemic to Central and South America and the southern US. The causative agent of Chagas disease is the protozoan parasite Trypanosoma cruzi, which is transmitted to vertebrate hosts via an insect vector. Chagas disease is a serious public health issueit is the leading cause of heart disease and cardiovascular death in Central and South America, and only malaria and schistosomiasis pose greater tropical disease burdens. The disease is estimated to infect 1618 million people in Latin America, and 120 million people are at risk of becoming infected. About 27% of those infected will develop cardiac symptoms, and 9% of cases progress to gastrointestinal or peripheral nervous system involvement. There are no vaccines to prevent infection, and no safe and effective drugs for therapy. It is estimated that at least 100,000 infected persons reside in the United States, raising public health concerns regarding the safety of blood and tissue banks. At Southwest Foundation for Biomedical Research (San Antonio, TX) a large, pedigreed colony of baboons, many of which have become infected naturally with T. cruzi, has provided an opportunity to develop the baboon as a primate model for studying the genetics of Chagas disease in humans.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 查加斯病是中美洲和南美以及美国南部的人畜共患病。 Chagas病的病因是原生动物寄生虫锥虫Cruzi，该锥虫通过昆虫载体传播到脊椎动物宿主。 查加斯病是一个严重的公共卫生问题，它是中美洲和南美心脏病和心血管死亡的主要原因，只有疟疾和血吸虫病造成更大的热带疾病负担。据估计，该疾病在拉丁美洲感染了16,800万人，有1.2亿人有感染的风险。 大约27％的感染者会出现心脏症状，而9％的病例则发展为胃肠道或周围神经系统的参与。没有防止感染的疫苗，也没有安全有效的治疗药物。 据估计，至少有100,000人居住在美国，这引起了公共卫生对血液和组织库安全的关注。 在西南生物医学研究基金会（德克萨斯州圣安东尼奥市），一个大型的，一个矮小的狒狒殖民地，其中许多殖民地已被克鲁齐（T.