Origins of Elasticity/Viscoelasticity in Knee Ligaments

膝关节韧带弹性/粘弹性的起源

• 批准号: 7485093
• 负责人: JEFFREY A. WEISS
• 金额: $ 22.12万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485093
• 关键词: Address; Anterior; Applied Research; Behavior; Biochemical; Biomechanics; Biomedical Engineering; Code; Collagen; Collagen Fiber; Collagen Fibril; Condition; Connective Tissue; Data; Degenerative polyarthritis; Dermatan Sulfate; Disease; Disruption; Elasticity; Elements; Extracellular Matrix; Family; Fiber; Ground Substance; Healed; Human; Indium; Inherited; Injury; Joint Instability; Joints; Knee; Lateral; Ligaments; Liquid substance; Measurement; Measures; Mechanics; Medial; Modeling; Molecular; Motion; Movement; Musculoskeletal; Natural History; Permeability; Phase; Phenotype; Play; Posterior Cruciate Ligament; Property; Proteoglycan; Published Comment; Range; Relative (related person); Research; Research Project Grants; Resistance; Role; Series; Stress; Stretching; Testing; Tissues; Weight-Bearing state; base; collateral ligament; crosslink; decorin; disease phenotype; fibrillogenesis; fluid flow; healing; kinematics; programs; viscoelasticity

DESCRIPTION (provided by applicant): The knee ligaments are short bands of tough fibrous connective tissue that guide normal joint motion and restrict abnormal joint movement. Although the injury and healing of knee ligaments have been topics of extensive study, fundamental information about the relationship between the ultrastructure of the tissue and its continuum level mechanical behavior is severely lacking. The decorin-based proteoglycans play an important role in collagen fibrillogenesis and may be important determinants of the material behavior of connective tissues. The objectives of this research are to investigate the roles of decorin-based proteoglycan crosslinks and fluid flow in the elastic and viscoelastic material behavior ligaments. The hypotheses to be addressed are 1) decorin-based crosslinks control the resistance of ligament to tensile loading transverse to the fiber direction and shear loading along the fiber direction by stretching during relative movement of the collagen fibrils; 2) a transversely isotropic hyperelastic constitutive model that incorporates structural information regarding decorin crosslinks and collagen fiber crimp will describe and predict the elastic material behavior of human knee ligaments; 3) The viscoelastic material behavior of ligament is due to fluid movement. These hypotheses will be addressed through a series of aims that combine experimental measurements from the molecular level to the continuum level. The results of this study will have important implications for understanding the fundamental role of the small proteoglycans and fluid flow in the viscoelastic behavior of fibrous connective tissues, and will help to understand the phenotypes associated with disease states that are related to deficiencies in the small proteoglycans.

描述（由申请人提供）：膝关节韧带是坚韧的纤维结缔组织的短带，可引导正常的关节运动并限制异常的关节运动。尽管膝关节韧带的损伤和愈合一直是广泛研究的主题，但有关组织超微结构与其连续水平机械行为之间关系的基本信息却严重缺乏。基于核心蛋白聚糖的蛋白聚糖在胶原纤维形成中发挥重要作用，并且可能是结缔组织材料行为的重要决定因素。本研究的目的是研究基于核心蛋白聚糖的蛋白聚糖交联和流体流动在弹性和粘弹性材料行为韧带中的作用。要解决的假设是1）基于核心蛋白聚糖的交联通过在胶原纤维相对运动期间拉伸来控制韧带对横向于纤维方向的拉伸载荷和沿纤维方向的剪切载荷的抵抗力； 2）横向各向同性超弹性本构模型，结合了核心蛋白聚糖交联和胶原纤维卷曲的结构信息，将描述和预测人类膝关节韧带的弹性材料行为； 3）韧带的粘弹性材料行为是由于流体运动造成的。这些假设将通过一系列目标来解决，这些目标结合了从分子水平到连续体水平的实验测量。这项研究的结果对于了解小蛋白多糖和流体流动在纤维结缔组织粘弹性行为中的基本作用具有重要意义，并将有助于了解与小蛋白多糖缺陷相关的疾病状态相关的表型。