UNC/UMN Baby Connectome Project

北卡罗来纳大学/UMN 婴儿连接组项目

• 批准号: 9506852
• 负责人: Jed Thomas Elison
• 金额: $ 101.65万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9506852
• 关键词: 5 year old; Adopted; Age; Area; Behavior assessment; Behavioral; Biomedical Research; Birth; Brain; Censuses; Child; Child Development; Childhood; Cognitive; Coupled; Custom; Data; Data Collection; Data Quality; Development; Dropout; Enrollment; Ensure; Equilibrium; Evaluation; Female; Funding; Goals; Head; Human; Hybrids; Image; Image Analysis; Infant; Link; Longevity; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Minnesota; Modeling; Modification; Morphologic artifacts; Motion; Multicenter Studies; Neck; North Carolina; Participant; Pattern; Positioning Attribute; Process; Publications; Quality Control; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Risk; Sampling; Scanning; Secure; Sedation procedure; Site; Surface; Thick; Time; United States National Institutes of Health; Universities; Washington; Work; attenuation; cohort; connectome; data acquisition; design; early childhood; ethnic diversity; experience; imaging approach; imaging study; improved; longitudinal design; male; novel; prospective; quality assurance; racial and ethnic; recruit; response; skills; sound; success; tool

Project Summary This application is in response to the RFA-MH-16-160, entitled “Lifespan Human Connectome Project (HCP): Baby Connectome”. Investigators at The University of North Carolina at Chapel Hill (UNC) and The University of Minnesota (UMN) will join forces to accomplish the goals outlined by this RFA. The team at UNC has over 10 years of experience in recruiting and imaging typically developing and at-risk children, scanning over 1000 children from birth to five years1-40. Well established infrastructure at the Biomedical Research Imaging Center (BRIC) at UNC and Center for Magnetic Resonance Research (CMRR) at UMN are in place to recruit and retain pediatric subjects and facilitate the coordination of pediatric imaging studies. Our past and ongoing studies for imaging children (birth – five years of age) without sedation have achieved an overall success rate of 81% and attrition rate of 29.3%. Our track record demonstrates that we possess the critical and essential components to successfully conduct longitudinal pediatric imaging studies focusing on early brain development, a critically-important aspect of this RFA. Our ability to recruit, retain, and image non-sedated, typically developing children is further strengthened by our image analysis team, which has developed novel image analysis tools specifically for early brain development. The expertise at UNC is complementary to and strengthened by the expertise of the team at UMN. The CMRR at UMN has been one of the leading groups in the HCP project and has developed novel MR imaging approaches to dramatically shorten data acquisition time. Furthermore, the team at UMN has extensive experience in behavioral and cognitive studies of early child development. Together, our combined team is well positioned to accomplish the goals of this RFA. To this end, a total of 500 typically developing children between birth and five years of age will be recruited across two data collection sites in a sequential cohort, accelerated longitudinal study design. The participants are divided into two main groups, longitudinal (n=285) and cross-sectional (n=215) groups, respectively. This hybrid longitudinal and cross-sectional design enables detailed characterization of early brain development from both brain structural/functional using MRI and behavioral aspects using behavioral assessments. All of the acquired images and behavioral assessments will undergo extensive quality assurance and control processes to ensure that high quality data is obtained and transferred to the Central Connectome Facility at Washington University. In addition, we will integrate novel image analysis tools, developed by our team onto the existing HCP pipelines.

项目概要 本申请是为了响应 RFA-MH-16-160，题为“人类寿命连接组” 项目（HCP）：北卡罗来纳大学教堂分校的婴儿连接组研究人员”。 希尔（北卡罗来纳大学）和明尼苏达大学（UMN）将联手实现这些目标 本 RFA 概述的 UNC 团队在招聘和招聘方面拥有 10 多年的经验。 对典型发育中和高危儿童进行成像，对 1000 多名从出生到五岁的儿童进行扫描 1-40 岁的生物医学研究成像中心 (BRIC) 拥有完善的基础设施。 北卡罗来纳大学和 UMN 磁共振研究中心 (CMRR) 已准备好招募和 保留儿科科目并促进儿科影像研究的协调。 以及正在进行的对不使用镇静剂的儿童（出生至五岁）进行成像的研究 我们的总体成功率达到 81%，流失率达到 29.3%。 表明我们拥有成功开展活动的关键和必要组成部分 纵向儿科影像研究侧重于早期大脑发育，这是一个至关重要的 我们招募、保留和成像非镇静剂的能力，通常是发展中的。 我们的图像分析团队进一步加强了儿童的能力，开发了新颖的图像 专门针对早期大脑发育的分析工具在北卡罗来纳大学的专业知识是互补的。 UMN 的 CMRR 一直是其中之一。 HCP 项目的领导小组并开发了新颖的 MR 成像方法 此外，UMN 的团队拥有广泛的经验。 我们在早期儿童发展的行为和认知研究方面拥有丰富的经验。 联合团队完全有能力实现本次 RFA 的目标。 将在两个项目中招募 500 名出生至五岁之间的正常发育儿童 连续队列中的数据收集站点，加速了纵向研究设计。 参与者分为两个主要组：纵向组（n=285）和横向组（n=215） 这种混合纵向和横截面设计可以实现详细的设计。 使用 MRI 和大脑结构/功能来表征早期大脑发育 使用行为评估的所有行为方面。 评估将经过广泛的质量保证和控制流程，以确保 获得高质量数据并将其传输到华盛顿的中央连接组设施 此外，我们还将把我们团队开发的新颖的图像分析工具集成到大学中。 现有的 HCP 管道。