Pilot Project A

试点项目A

基本信息

批准号：
7900611
负责人：
LINDA MADSEN
金额：
$ 9.69万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7900611
关键词：
21 year old Accounting Adipose tissue Adult Androstenedione Biological Markers Blood specimen Body mass index Body of uterus Breast Cancer Control Cancer Etiology Case-Control Studies Cessation of life Clinic Collaborations Collection Colorectal Cancer Confidence Intervals Contraceptive methods Development Diabetes Mellitus Diagnosis Discipline of obstetrics Doctor of Medicine Doctor of Philosophy Early Diagnosis Endometrial Endometrial Carcinoma Enzymes Epidemiologic Studies Estrogen Therapy Estrogens Estrone Family history of Future Genetic Polymorphism Goals Gynecologic Gynecologic Oncology Gynecology Habits Hispanics Hormone replacement therapy Hospitals Immunoassay Incidence Infertility Insulin Insulin Resistance Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Insulin-Like Growth Factor II Interview Knowledge Link Logistic Regressions Malignant Female Reproductive System Neoplasm Malignant Neoplasms Manuscripts Measurement Measures Medical Modeling Modification Newly Diagnosed Not Hispanic or Latino Nulliparity Obesity Odds Ratio Participant Pathway interactions Personal Communication Physical activity Pilot Projects Population Sciences Population Study Predisposition Preparation Puerto Rican Puerto Rico Recording of previous events Recruitment Activity Reporting Reproductive History Research Research Training Resources Risk Risk Factors Role Science Serum Smoking Somatomedins Survival Rate Syndrome System Time Tissue Sample Training United States Universities University of Texas M D Anderson Cancer Center Uterine Cancer Weight Woman abstracting adiponectin anticancer research base cancer risk carcinogenesis drinking epidemiology study indexing insulin sensitivity interest neoplasm registry outcome forecast population based professor programs reproductive treatment response

项目摘要

Title: Pilot Project A: Pilot Case-Comparison Study of Insulin Resistance, Adiponectin and Endometrial Cancer in Puerto Rico CO-LEADERS: MDACC - Karen H. Lu, M.D., Associate Professor, Gynecologic Oncology UPRCCC - Guillermo Tortolero-Luna, M.D., Ph.D., Director, Cancer Control and Population Sciences Program ABSTRACT Cancer of the uterine corpus is the most common gynecologic malignancy in the United States, with 40,100 new cases and 7,470 cancer-related deaths estimated for 2008. Similarly, in Puerto Rico endometrial cancer is the most common gynecologic malignancy, and the third leading cause of cancer in women behind breast and colorectal cancer. In the year 2003, there were 321 new cases of endometrial cancer reported to the Puerto Rico Cancer Registry, accounting for 6% of all cancers in women. Recent observations suggest that new pathways need to be considered, including evidence for a possible role of insulin and the insulin-like growth factor system. We will conduct a case-comparison hospital-based pilot study to assess the role of insulin resistance and adiponectin, a biomarker of insulin resistance, as risk factors for endometrial cancer among Puerto Rican women. One hundred women (21 years and older) with a newly diagnosed, histplogically confirmed primary endometrial cancer will be selected at the Gynecologic Oncology clinic of the Department of Obstetrics and Gynecology at the University of Puerto Rico Medical Science Campus (UPR-MSC) and compared to 100 women selected among attendees to two Obstetrics and Gynecology clinics at the UPRMSC. Participants will undergo a face-to-face interview in which the following is collected: demographic information, smoking and drinking habits, weight history, personal and family medical history, reproductive and menstrual history, history of contraception and hormone replacement therapy, history of infertility, and levels of physical activity. In addition, women will undergo anthropometric measurements and collection of blood samples for measurements of insulin resistance. Insulin resistance (IR) will be measured using the quantitative insulin sensitivity check index (QUICKI). In addition, serum adiponectin levels, which correlate with insulin resistance, will be measured using a commercially available quantitative sandwich enzyme-linked immunoassay (ELISA). Univariate and multivariate unconditional logistic regression models will be used to assess the association of endometrial cancer with insulin resistance and serum adiponectin. The odds ratio (OR) and its 95% confidence intervals will be used to estimate the strength of the association between IR and other factors of interest and endometrial cancer.

标题：试点项目 A：胰岛素抵抗、脂联素和胰岛素抵抗的试点案例比较研究波多黎各的子宫内膜癌联合领导者：MDACC - Karen H. Lu，医学博士，妇科肿瘤学副教授 UPRCCC - Guillermo Tortolero-Luna，医学博士、哲学博士、癌症控制和治疗主任人口科学项目抽象的子宫体癌是美国最常见的妇科恶性肿瘤，有 40,100 例 2008 年估计有 7,470 例新病例和 7,470 例与癌症相关的死亡。同样，在波多黎各，子宫内膜癌是最常见的妇科恶性肿瘤，也是女性癌症中仅次于乳腺癌的第三大原因和结直肠癌。 2003年，共报告了321例子宫内膜癌新病例。波多黎各癌症登记处，占女性所有癌症的 6%。最近的观察表明需要考虑新的途径，包括胰岛素和类胰岛素可能发挥作用的证据生长因子系统。我们将进行一项以医院为基础的案例比较试点研究，以评估胰岛素抵抗和脂联素（胰岛素抵抗的生物标志物）是子宫内膜癌的危险因素在波多黎各妇女中。一百名女性（21 岁及以上）新诊断出组织学确诊原发性子宫内膜癌将在妇科肿瘤科门诊选择波多黎各大学医学科学校区 (UPR-MSC) 的妇产科和相比之下，从 UPRMSC 两个妇产科诊所的参加者中选出了 100 名女性。参与者将接受面对面采访，其中收集以下信息：人口统计信息、吸烟和饮酒习惯、体重史、个人和家庭病史、生殖和月经史、避孕和激素替代治疗史、不孕史以及体力活动。此外，女性还将接受人体测量和血液采集用于测量胰岛素抵抗的样品。胰岛素抵抗（IR）将使用定量测量胰岛素敏感性检查指数（QUICKI）。此外，血清脂联素水平与胰岛素相关抗性，将使用市售的定量夹心酶联法进行测量免疫测定（ELISA）。单变量和多变量无条件逻辑回归模型将用于评估子宫内膜癌与胰岛素抵抗和血清脂联素的关联。优势比 (OR) 及其 95% 置信区间将用于估计 IR 和其他感兴趣的因素和子宫内膜癌。