Exercise Intervention on Cortisol Secretion and Cardiovascular Disease Risk

运动干预对皮质醇分泌和心血管疾病风险的影响

• 批准号: 7487902
• 负责人: NOHA Hassan FARAG
• 金额: $ 6.16万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-04 至 2010-09-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7487902
• 关键词: Adolescent; Adult; Blood Pressure; Body fat; Cardiovascular Diseases; Characteristics; Child; Childhood; Deposition; Diabetes Mellitus; Epidemic; Epidemiology; Exercise; Fatty acid glycerol esters; Health Hazards; Hydrocortisone; Incidence; Intervention; Life; Life Style; Lipids; Location; Metabolic syndrome; Morbidity - disease rate; Native Americans; Obesity; Oklahoma; Personal Satisfaction; Physical activity; Population; Prevalence; Public Health; Rate; Risk; Salivary; Training Programs; Tribes; Universities; Week; Weight; cardiovascular disorder risk; hypothalamic-pituitary-adrenal axis; mortality; sedentary

DESCRIPTION (provided by applicant): The prevalence of obesity in children and adolescents is increasing at an alarming rate. Evidence exists that childhood obesity is associated with an increased risk of morbidity and mortality through adulthood. The US population has moved towards a sedentary life style, which has further exacerbated the obesity epidemic. Central body fat deposition has emerged as an important predictor of the health hazards of obesity. Increased levels of cortisol cause central fat deposition characteristic of the metabolic syndrome. The function of the hypothalamic-pituitary-adrenal axis in obesity has been studied in adults. The correlation between cortisol and the cardiovascular disease risk profile in adolescents is not well established, particularly as related to obesity. Native Americans have a higher incidence of obesity and cardiovascular disease. In this study, we will determine correlates of salivary cortisol in adolescents living in Anadarko, a central location of the Seven Tribes of Southwest Oklahoma. We will also examine the effect of a 12-week standardized exercise training program on salivary cortisol and the cardiovascular disease risk profile in at risk adolescents.

描述（由申请人提供）：儿童和青少年肥胖症患病率正在以惊人的速度增加。有证据表明，儿童肥胖与成年期发病和死亡的风险增加有关。美国人口已朝着久坐的生活方式发展，这进一步加剧了肥胖症的流行。中枢体脂肪沉积已成为肥胖健康危害的重要预测指标。皮质醇水平的增加导致代谢综合征的中枢脂肪沉积特征。在成年人中已经研究了下丘脑 - 垂体 - 肾上腺轴的功能。青少年的皮质醇与心血管疾病风险特征之间的相关性尚未确定，尤其是与肥胖有关。美洲原住民的肥胖症和心血管疾病的发生率更高。在这项研究中，我们将确定居住在俄克拉荷马州七个部落的中心地点的阿纳达科的青少年中的唾液皮质醇的相关性。我们还将研究一个为期12周的标准运动训练计划对唾液皮质醇和心血管疾病风险的影响，对AT风险青少年的影响。