Effect of Soluble Corn Fiber supplementation for 1 year on bone metabolism in adolescents (MetA-Bone Trial)

补充可溶性玉米纤维一年对青少年骨代谢的影响（MetA-Bone 试验）

• 批准号: 10764638
• 负责人: CRISTINA PALACIOS
• 金额: $ 14.32万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-11 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764638
• 关键词: 14 year old; 15 year old; Address; Administrative Supplement; Adolescent; Adult; Age; Bacteria; Bacteroides; Bacteroidetes; Biological Markers; Black Populations; Black race; Blood specimen; Body Composition; Body Weight; Body Weight decreased; Body fat; Botanical dietary supplements; C-reactive protein; Canada; Cardiovascular Diseases; Child; Childhood; Chronic; Chronic Disease; Circulation; Communities; Development; Diabetes Mellitus; Diet; Dual-Energy X-Ray Absorptiometry; Fatty acid glycerol esters; Fiber; Firmicutes; Funding; Future; Growth; Health; Hispanic; Hispanic Populations; Inflammation; Inflammatory; Interleukin-6; Intervention Studies; Intestinal permeability; Inulin; Leukocyte L1 Antigen Complex; Longitudinal Studies; Maintenance; Measures; Mediating; Mentorship; Metabolic syndrome; Minority; Minority Groups; Obesity; Outcome; Oxidative Stress; Participant; Prevalence; Randomized; Research; Role; Sampling; Scanning; Serum; Supplementation; Testing; Thailand; Thinness; Time; Tissues; Training; Urine; biobank; bone; bone health; bone metabolism; cardiometabolism; cardiovascular disorder risk; dietary supplements; disorder prevention; double-blind placebo controlled trial; dysbiosis; follow-up; graduate student; gut microbiome; improved; indexing; microbial; microbiome; microbiome composition; microbiota; minority children; parent grant; prebiotics; prevent; public health relevance; recruit; systemic inflammatory response; therapy design; urinary

Project Summary This Administrative Supplement for Research on Dietary Supplements is for year 5 of the funded parent grant “MetA-Bone Trial” (# 5R01HD098589-04), a randomized double-blinded placebo- controlled trial to determine the effects of 1-year soluble corn fiber (SCF) supplementation on bone metabolism in children. This proposal will expand our research on the effects of SCF (a prebiotic fiber) on the gut microbiome diversity and how this is associated with changes in body composition inflammatory biomarkers in this sample. A total of 110 participants have been recruited so far, of which >75% are minority (68% are Hispanics and 8% are Blacks). Fecal, 24-h urine, and blood samples are being collected and saved in our biorepository for future analysis. Evidence shows that the gut microbiome is associated with obesity, which is particularly higher among Hispanics and Blacks. Obesity has been associated with a different bacteria composition (less bacterial diversity and reduced Bacteroidetes/Firmicutes ratio). Diets low in fiber (which is very common in US children) also changes the microbiota. These changes in the gut could lead to chronic, low-grade inflammation. This could be reversed or improved by prebiotic fiber supplementation. The only 2 studies to date supplementing children with inulin (another type of prebiotic fiber) found significant decreases in body weight z-score, percent body fat, IL-6, and gut microbiome composition. However, to our knowledge, there are no studies evaluating the effects of SCF on gut microbiome diversity, body composition, and in inflammatory biomarkers in children or in minorities. The aims of this administrative supplement are: (1) Evaluate the changes in the gut microbiome diversity (through Shannon, Simpson, and Inverse Simpson indices, measures of richness and evenness; new analyses) with 1-year SCF supplementation and how this is associated with changes in body composition (% fat mass and lean mass from DXA scan); (2) Evaluate the changes in inflammatory biomarkers (fecal calproctectin, urinary IL-6, and serum CRP; new analyses) with 1-year SCF supplementation and if these changes are mediated by changes in body composition; and (3) Engage 2 graduate students in training and mentorship to build future research capacity for studying the role of dietary supplements in health and disease prevention. If successful, the results from this application will improve our understanding of the role of SCF on gut microbiome, body composition, and inflammation. This could lead to designing interventions to promote supplementing diets with SCF for improving health and potentially preventing chronic conditions associated with excessive fat mass and low-grade inflammation in minority children and adolescents.

项目摘要 这种用于饮食补充剂研究的行政补充是资助的第五年 父母赠款“元骨试验”（＃5R01HD098589-04），一个随机的双叶安慰剂 - 对照试验确定补充1年固体玉米纤维（SCF）对 儿童的骨代谢。该建议将扩大我们对SCF影响的研究（a 在肠道微生物组多样性上的益生元纤维）以及与身体变化的关系 该样品中的组成炎症生物标志物。共有110名参与者 迄今为止招募的招募，其中> 75％是少数族裔（68％是西班牙裔，8％是黑人）。粪便，24-H 尿液和血液样本被收集并保存在我们的生物验证中，以供将来分析。 证据表明肠道微生物组与肥胖有关，这特别高 在西班牙裔和黑人中。肥胖与不同的细菌组成有关 （细菌的多样性较少，较少的细菌群/企业比率）。低纤维的饮食（就是 在美国儿童中非常常见）也会改变菌群。肠道中的这些变化可能会导致 慢性低度炎症。这可以通过益生元纤维逆转或改进 补充。迄今为止仅有的2项研究补充了丁香蛋白的儿童（另一种类型的 益生元纤维）发现体重z得分，体内脂肪百分比，IL-6和肠道的大幅下降 微生物组组成。但是，据我们所知，尚无研究评估影响 肠道微生物组多样性，身体成分和儿童炎症生物标志物的SCF 或少数民族。该行政补充的目的是：（1）评估 肠道微生物组的多样性（通过香农，辛普森和倒数辛普森指数， 丰富与偶数；新分析）补充了1年的SCF以及如何补充 与身体成分的变化有关（脂肪质量％和DXA扫描的瘦质量）； （2） 评估炎症生物标志物的变化（粪便Calproctectin，尿IL-6和系列 CRP；新分析）补充了1年的SCF，如果这些更改是由 身体成分的变化； （3）让2名研究生培训和指导 建立研究饮食补充剂在健康和疾病中的作用的未来研究能力 预防。如果成功，此应用程序的结果将提高我们对 SCF在肠道微生物组，身体组成和炎症中的作用。这可能会导致设计 干预措施以促进SCF补充饮食以改善健康，并可能 防止与过量脂肪质量和低度炎症有关的慢性病 少数族裔儿童和青少年。

项目成果

Facilitators and barriers of children's participation in nutrition, physical activity, and obesity interventions: A systematic review.

• DOI: 10.1111/obr.13335
• 发表时间: 2021-12
• 期刊: OBESITY REVIEWS
• 影响因子: 8.9
• 作者: Clayton, Priscilla;Connelly, Jeneene;Ellington, Malik;Rojas, Vicky;Lorenzo, Yaisli;Trak-Fellermeier, Maria Angelica;Palacios, Cristina
• 通讯作者: Palacios, Cristina

Macronutrient Adequacy of a Mediterranean-type Meal Examined at Recommended and Below Recommended Energy Values.

在推荐和低于推荐能量值下检查地中海式膳食的常量营养素充足性。

• DOI: 10.26502/jfsnr.2642-110000129
• 发表时间: 2023
• 期刊: Journal of food science and nutrition research
• 作者: Preston,AlanM;Clayton,PriscillaK
• 通讯作者: Clayton,PriscillaK

High Carbohydrate vs High Fat Diets: Which is Preferable for Long-term Use?

高碳水化合物饮食与高脂肪饮食：哪种更适合长期使用？

• DOI: 10.26502/jfsnr.2642-110000126
• 发表时间: 2023
• 期刊: Journal of food science and nutrition research
• 作者: Preston,AlanM;Rodriguez,CindyA;Preston,MariannaM
• 通讯作者: Preston,MariannaM

Effect of soluble corn fiber supplementation for 1 year on bone metabolism in children, the MetA-bone trial: Rationale and design.

补充可溶性玉米纤维 1 年对儿童骨代谢的影响，MetA-骨试验：基本原理和设计。

• DOI: 10.1016/j.cct.2020.106061
• 发表时间: 2020
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Palacios,C;Trak-Fellermeier,MA;Pérez,CM;Huffman,F;HernandezSuarez,Y;Bursac,Z;Gambon,TB;Nakatsu,CH;Weaver,CM
• 通讯作者: Weaver,CM