Effect of Soluble Corn Fiber supplementation for 1 year on bone metabolism in adolescents (MetA-Bone Trial)

补充可溶性玉米纤维一年对青少年骨代谢的影响（MetA-Bone 试验）

• 批准号: 10764638
• 负责人: CRISTINA PALACIOS
• 金额: $ 14.32万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-11 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764638
• 关键词: 14 year old; 15 year old; Address; Administrative Supplement; Adolescent; Adult; Age; Bacteria; Bacteroides; Bacteroidetes; Biological Markers; Black Populations; Black race; Blood specimen; Body Composition; Body Weight; Body Weight decreased; Body fat; Botanical dietary supplements; C-reactive protein; Canada; Cardiovascular Diseases; Child; Childhood; Chronic; Chronic Disease; Circulation; Communities; Development; Diabetes Mellitus; Diet; Dual-Energy X-Ray Absorptiometry; Fatty acid glycerol esters; Fiber; Firmicutes; Funding; Future; Growth; Health; Hispanic; Hispanic Populations; Inflammation; Inflammatory; Interleukin-6; Intervention Studies; Intestinal permeability; Inulin; Leukocyte L1 Antigen Complex; Longitudinal Studies; Maintenance; Measures; Mediating; Mentorship; Metabolic syndrome; Minority; Minority Groups; Obesity; Outcome; Oxidative Stress; Participant; Prevalence; Randomized; Research; Role; Sampling; Scanning; Serum; Supplementation; Testing; Thailand; Thinness; Time; Tissues; Training; Urine; biobank; bone; bone health; bone metabolism; cardiometabolism; cardiovascular disorder risk; dietary supplements; disorder prevention; double-blind placebo controlled trial; dysbiosis; follow-up; graduate student; gut microbiome; improved; indexing; microbial; microbiome; microbiome composition; microbiota; minority children; parent grant; prebiotics; prevent; public health relevance; recruit; systemic inflammatory response; therapy design; urinary

Project Summary This Administrative Supplement for Research on Dietary Supplements is for year 5 of the funded parent grant “MetA-Bone Trial” (# 5R01HD098589-04), a randomized double-blinded placebo- controlled trial to determine the effects of 1-year soluble corn fiber (SCF) supplementation on bone metabolism in children. This proposal will expand our research on the effects of SCF (a prebiotic fiber) on the gut microbiome diversity and how this is associated with changes in body composition inflammatory biomarkers in this sample. A total of 110 participants have been recruited so far, of which >75% are minority (68% are Hispanics and 8% are Blacks). Fecal, 24-h urine, and blood samples are being collected and saved in our biorepository for future analysis. Evidence shows that the gut microbiome is associated with obesity, which is particularly higher among Hispanics and Blacks. Obesity has been associated with a different bacteria composition (less bacterial diversity and reduced Bacteroidetes/Firmicutes ratio). Diets low in fiber (which is very common in US children) also changes the microbiota. These changes in the gut could lead to chronic, low-grade inflammation. This could be reversed or improved by prebiotic fiber supplementation. The only 2 studies to date supplementing children with inulin (another type of prebiotic fiber) found significant decreases in body weight z-score, percent body fat, IL-6, and gut microbiome composition. However, to our knowledge, there are no studies evaluating the effects of SCF on gut microbiome diversity, body composition, and in inflammatory biomarkers in children or in minorities. The aims of this administrative supplement are: (1) Evaluate the changes in the gut microbiome diversity (through Shannon, Simpson, and Inverse Simpson indices, measures of richness and evenness; new analyses) with 1-year SCF supplementation and how this is associated with changes in body composition (% fat mass and lean mass from DXA scan); (2) Evaluate the changes in inflammatory biomarkers (fecal calproctectin, urinary IL-6, and serum CRP; new analyses) with 1-year SCF supplementation and if these changes are mediated by changes in body composition; and (3) Engage 2 graduate students in training and mentorship to build future research capacity for studying the role of dietary supplements in health and disease prevention. If successful, the results from this application will improve our understanding of the role of SCF on gut microbiome, body composition, and inflammation. This could lead to designing interventions to promote supplementing diets with SCF for improving health and potentially preventing chronic conditions associated with excessive fat mass and low-grade inflammation in minority children and adolescents.

项目概要 本膳食补充剂研究行政补充适用于资助的第 5 年 家长资助“MetA-Bone Trial”（# 5R01HD098589-04），一项随机双盲安慰剂 对照试验确定补充 1 年可溶性玉米纤维 (SCF) 对健康的影响 该提案将扩大我们对 SCF（a）影响的研究。 益生元纤维）对肠道微生物组多样性的影响及其与身体变化的关系 该样本中共有 110 名参与者进行了炎症生物标志物的成分分析。 到目前为止已招募，其中> 75％是少数族裔（68％是西班牙裔，8％是黑人），24小时。 尿液和血液样本正在被收集并保存在我们的生物样本库中以供将来分析。 有证据表明肠道微生物组与肥胖相关，尤其是肥胖率更高 西班牙裔和黑人的肥胖与不同的细菌组成有关。 （细菌多样性减少，拟杆菌门/厚壁菌门比例降低）饮食中纤维含量低（即纤维含量低）。 在美国儿童中很常见）也会改变肠道微生物群，这些变化可能会导致。 益生元纤维可以逆转或改善慢性、低度炎症。 迄今为止仅有 2 项为儿童补充菊粉（另一种类型）的研究。 益生元纤维）发现体重 Z 值、体脂百分比、IL-6 和肠道显着降低 然而，据我们所知，还没有研究评估其影响。 SCF 对儿童肠道微生物组多样性、身体成分和炎症生物标志物的影响 本行政补充文件的目的是： (1) 评估 肠道微生物组多样性（通过香农指数、辛普森指数和逆辛普森指数、 丰富度和均匀度；新分析）以及 1 年 SCF 补充以及这是如何实现的 与身体成分的变化相关（DXA 扫描的脂肪质量和瘦肉质量百分比）（2）； 评估炎症生物标志物（粪便钙菌素、尿液 IL-6 和血清 CRP；新分析）补充 1 年 SCF，以及这些变化是否由以下因素介导 身体成分的变化；以及 (3) 让 2 名研究生参与培训和指导 建立未来研究膳食补充剂在健康和疾病中的作用的研究能力 如果成功，该应用的结果将提高我们对这一问题的理解。 SCF 对肠道微生物组、身体成分和炎症的作用这可能会导致设计。 促进补充 SCF 饮食以改善健康的干预措施，并有可能 预防与脂肪过多和低度炎症相关的慢性疾病 少数民族儿童和青少年。

项目成果

Facilitators and barriers of children's participation in nutrition, physical activity, and obesity interventions: A systematic review.

• DOI: 10.1111/obr.13335
• 发表时间: 2021-12
• 期刊: OBESITY REVIEWS
• 影响因子: 8.9
• 作者: Clayton, Priscilla;Connelly, Jeneene;Ellington, Malik;Rojas, Vicky;Lorenzo, Yaisli;Trak-Fellermeier, Maria Angelica;Palacios, Cristina
• 通讯作者: Palacios, Cristina

Macronutrient Adequacy of a Mediterranean-type Meal Examined at Recommended and Below Recommended Energy Values.

在推荐和低于推荐能量值下检查地中海式膳食的常量营养素充足性。

• DOI: 10.26502/jfsnr.2642-110000129
• 发表时间: 2023
• 期刊: Journal of food science and nutrition research
• 作者: Preston,AlanM;Clayton,PriscillaK
• 通讯作者: Clayton,PriscillaK

High Carbohydrate vs High Fat Diets: Which is Preferable for Long-term Use?

高碳水化合物饮食与高脂肪饮食：哪种更适合长期使用？

• DOI: 10.26502/jfsnr.2642-110000126
• 发表时间: 2023
• 期刊: Journal of food science and nutrition research
• 作者: Preston,AlanM;Rodriguez,CindyA;Preston,MariannaM
• 通讯作者: Preston,MariannaM

Effect of soluble corn fiber supplementation for 1 year on bone metabolism in children, the MetA-bone trial: Rationale and design.

补充可溶性玉米纤维 1 年对儿童骨代谢的影响，MetA-骨试验：基本原理和设计。

• DOI: 10.1016/j.cct.2020.106061
• 发表时间: 2020
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Palacios,C;Trak-Fellermeier,MA;Pérez,CM;Huffman,F;HernandezSuarez,Y;Bursac,Z;Gambon,TB;Nakatsu,CH;Weaver,CM
• 通讯作者: Weaver,CM