FASEB SRC on Protein Kinases and Protein Phosphorylation

FASEB SRC 关于蛋白激酶和蛋白磷酸化

基本信息

批准号：
9754337
负责人：
Jin Zhang
金额：
$ 0.4万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-03 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9754337
关键词：
Area Biochemical Biochemistry Biological Process Biology California Cardiac Career Mobility Cellular biology Chemicals Clinical Collaborations Communication Data Development Diabetes Mellitus Diagnosis Discipline Disease Disease model Drug Industry Drug Targeting Educational workshop Event FDA approved Faculty Fertilization Fostering Funding Goals Growth and Development function Human Inflammation Inflammatory Knowledge Lighting Link Malignant Neoplasms Mediating Medicine Metabolic Diseases Metabolic syndrome Metabolism Methodology Methods Molecular Neurons New Territories Normal Cell Oncogenic Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases Play Prevention Principal Investigator Process Protein Engineering Protein Kinase Protein Kinase Protein Phosphorylation Reporting Research Research Personnel Resort Role Science Scientist Senior Scientist Signal Transduction Site Structure Students System Systems Analysis Systems Biology Technology Time Translational Research Underrepresented Groups Underrepresented Minority Woman career career development cell growth forging human disease improved in vivo Model innovation insight interest kinase inhibitor meetings minority scientist multidisciplinary next generation novel novel anticancer drug novel therapeutics oncology posters programs recruit social spatiotemporal structural biology summer research symposium therapeutic development therapeutic target tool

项目摘要

Program Director/Principal Investigator : Zhang, Jin Protein phosphorylation is vitally important in the molecular communications that control cellular state and activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The study of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of research that has driven methodological and conceptual advances and is increasingly contributing to the development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved by the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under development. This strong clinical connection provides an exciting link with translational science. In this application, we request funds to support attendance of trainees, junior faculty and traditionally underrepresented groups at the 2019 FASEB Summer Research conference on Protein Kinases and Protein Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that deal with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a primary venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance, and disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein phosphorylation, in human disease. The 2019 FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular mechanisms that regulate important biological processes and facilitate the identification of critical targets for the diagnosis, prevention, treatment, and cure of human diseases. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

项目主任/首席研究员：张金蛋白质磷酸化对于控制细胞状态的分子通讯至关重要它是由激酶和磷酸酶介导的动态过程，在正常情况下受到精确调节。细胞，并在许多人类疾病中失调，包括糖尿病、炎症性疾病和癌症。蛋白质磷酸化机制及其在信号系统中的功能的研究是一个活跃的领域研究推动了方法论和概念的进步，并日益为治疗方案的开发。蛋白激酶在癌症中经常被失调，并且它们已经被取消。事实上，大多数新的抗癌药物都已获得批准。 FDA 在过去几年中针对激酶推出了数百种新的激酶抑制剂这种强大的临床联系为转化科学提供了令人兴奋的联系。在此申请中，我们请求资金来支持学员、初级教员和传统教员的出席 2019 年 FASEB 夏季蛋白激酶和蛋白质研究会议上代表性不足的群体这个两年一度的会议始于 1983 年，是一次重要的跨学科聚会。汇集具有不同专业知识的科学家，以增进对生化机制的理解和磷酸化事件的基本原则——这是本次会议与其他会议不同的一个焦点这次 FASEB 会议一直是、并将继续是一次讨论信号网络和系统方法的会议。宣布该领域突破的主要场所，并有一个长期目标来增强，并传播知识，从而改进针对异常激酶活性和蛋白质的治疗方法 2019 年 FASEB 蛋白激酶科学研究会议和蛋白质磷酸化旨在突出蛋白质磷酸化领域的最新前沿发现，以将结构生物学、生物化学、系统生物学、化学生物学、蛋白质工程和这将促进这些通常独立的学科之间的交叉受精，以刺激新的品系。的研究，以及加强不同科学家的沟通、合作和职业发展最终目标是推动该领域的发展，以获得对分子的更好理解。调节重要生物过程并促进关键目标识别的机制人类疾病的诊断、预防、治疗和治愈。 OMB 编号 0925-0001/0002（修订版 01/18 批准至 03/31/2020）页面延续格式页面