A Novel 3D Surface-Image Guided Adaptive Therapy System (IGAT) for Breast Irradia
新型 3D 表面图像引导自适应治疗系统 (IGAT) 用于乳腺 Irradia
基本信息
- 批准号:7405297
- 负责人:
- 金额:$ 0.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-04-01 至 2008-10-01
- 项目状态:已结题
- 来源:
- 关键词:AlgorithmsAmericanBiomechanicsBreastCaliforniaChestClinicalComputing MethodologiesConditionDailyDataDoseEffectivenessElementsEnsureEquipmentExcisionGeneral HospitalsGenerationsGrantHospitalsImageIndividualInvasiveInvestigationLasersLeadLocationMammary Gland ParenchymaMarketingMassachusettsMeasurementModalityModelingNormal tissue morphologyOther Imaging ModalitiesPatientsPerformancePersonal SatisfactionPhasePrimary NeoplasmProceduresQualifyingRadiationRadiation therapyRecurrenceResearchResearch PersonnelScanningSkinSmall Business Funding MechanismsSmall Business Innovation Research GrantStagingSurfaceSystemTechniquesTestingThree-Dimensional ImageThree-Dimensional ImagingTimeToxic effectTreatment FailureTumor VolumeUniversitiesVisitWomanX-Ray Computed TomographyX-Ray Filmbasebreast lumpectomyconceptcostdesigndigitalfollow-upimprovedirradiationlymph nodesmalignant breast neoplasmmillimeternovelnovel strategiesprogramsprototyperesearch studysensorsimulationsoftware developmentsoftware systemstreatment planningtumor
项目摘要
DESCRIPTION (provided by applicant): One in every 8 American women develops breast cancer at some point in their lifetime. It is estimated that more than 225,000 new cases of breast cancer occur among American women each year. Breast Conserving Therapy (BCT), defined as excision of the primary tumor and adjacent breast tissue followed by radiation therapy of the breast and/or regional lymph nodes, has been widely accepted as a treatment option for most women with clinical Stage I or II invasive breast cancer. Among the various treatment mechanisms, partial Irradiation treatment through the clever use of megavoltage external beams (called partial breast irradiation (PBI) in this proposal) is a less invasive more focused treatment. It uses a treatment planning CT scan and combines multiple radiation treatment fields to deliver precise doses of radiation externally to the lumpectomy cavity. The major technical challenge for a successful PBI treatment is the precise delivery of radiation dose to the subsurface target volume. Inaccurate localization of the target volume could result in PBI treatment failure due to recurrence caused by geometric miss of the tumor, and/or unacceptable toxicity caused by daily irradiating normal tissue at a high fractional dose. The primary objective of this SBIR program is to develop a novel, three-dimensional (3D), image-guided, adaptive therapy (3D IGAT) technique to improve the precision of radiation delivery during the procedure of Partial Breast Irradiation (PBI) treatment. We propose to develop a novel approach of patient repositioning and error correction based on accurate registration between the treatment-planning computed tomography (CT) scan and the 3D surface profiles of a patient's breast acquired during the treatment. Since 3D surface images can be acquired in real-time and will cause no additional irradiation, the proposed repositioning approach provides an elegant way to solve the two difficulties of the traditional laser line based alignment system. One is accurate localization of the lumpectomy field for dose delivery, and the other is accurate and fast patient repositioning for return visits. The major advantages of this novel technique include the following: 3D surface images. The research results of this SBIR project will lead directly to a new generation of commercial products for accurate and adaptive therapy systems in radiotherapy field. The research results of this SBIR project will lead directly to a new generation of commercial products for adaptive therapy systems in radiotherapy field. With over 2,000 radiation treatment machines in the US and many more worldwide, the market for a clinically acceptable 3D-Camera-based adaptive therapy system is significant.
描述(由申请人提供):一生中的某个时刻,每8位美国妇女每8个女性就会患乳腺癌。据估计,每年美国女性中有225,000多例新的乳腺癌病例。乳房保存治疗(BCT)定义为原发性肿瘤和邻近乳腺组织的切除,然后进行乳腺和/或区域淋巴结的放射治疗,已被广泛接受为大多数患有I期I或II期临床II或II型浸润性乳腺癌的女性的治疗选择。在各种治疗机制中,通过巧妙地使用巨型外束(在此提案中称为部分乳房照射(PBI)),部分辐照治疗是一种侵入性的更为浓缩的治疗方法。它使用治疗计划CT扫描并结合了多个辐射治疗场,以向外部向乳房切除术腔提供精确的辐射剂量。成功进行PBI治疗的主要技术挑战是将辐射剂量的精确输送到地下目标体积。目标体积的定位不正确可能导致由于肿瘤的几何失误引起的复发和/或由高分数剂量下的正常组织引起的不可接受的毒性引起的复发而导致PBI治疗失败。该SBIR计划的主要目的是开发一种新型的三维(3D),图像引导,适应性疗法(3D IGAT)技术,以提高部分乳腺辐照过程(PBI)治疗过程中辐射递送的精度。我们建议基于治疗计划计算机断层扫描(CT)扫描和治疗过程中患者乳房的3D表面特征之间的准确注册,开发出一种新型的患者重新定位和误差校正方法。由于3D表面图像可以实时获取,并且不会引起额外的辐射,因此提出的重新定位方法提供了一种优雅的方法来解决基于传统激光线的对准系统的两个困难。一个是对剂量递送的肿块切除术场的准确定位,另一个是准确且快速的患者重新定位以进行回访。这种新技术的主要优点包括以下内容:3D表面图像。该SBIR项目的研究结果将直接导致新一代的商业产品,用于放射治疗领域的准确和适应性治疗系统。该SBIR项目的研究结果将直接导致放射疗法领域的自适应治疗系统的新一代商业产品。在美国,拥有超过2,000台辐射治疗机,在全球范围内,临床上可接受的基于3D相机的自适应治疗系统的市场非常重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
James Z Wen其他文献
James Z Wen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('James Z Wen', 18)}}的其他基金
Real-tme High-resolution 3D Tumor Motion Tracking system for Adaptive Moving Aper
用于自适应移动 Aper 的实时高分辨率 3D 肿瘤运动跟踪系统
- 批准号:
7670885 - 财政年份:2009
- 资助金额:
$ 0.1万 - 项目类别:
2D/3D HYBRID TECHNOLOGY AND SOFTWARE SYSTEM FOR DETECTION OF ABNORMALITIES FROM C
用于检测 C 异常的 2D/3D 混合技术和软件系统
- 批准号:
8324333 - 财政年份:2005
- 资助金额:
$ 0.1万 - 项目类别:
A Novel 3D Surface-Image Guided Adaptive Therapy System (IGAT) for Breast Irradia
新型 3D 表面图像引导自适应治疗系统 (IGAT) 用于乳腺 Irradia
- 批准号:
7688688 - 财政年份:2004
- 资助金额:
$ 0.1万 - 项目类别:
A Novel 3D Surface-Image Guided Adaptive Therapy System (IGAT) for Breast Irradia
新型 3D 表面图像引导自适应治疗系统 (IGAT) 用于乳腺 Irradia
- 批准号:
7729265 - 财政年份:2004
- 资助金额:
$ 0.1万 - 项目类别:
相似海外基金
Automatic, Opportunistic Surveillance of Hip Bone Fragility in X-ray Images
X 射线图像中髋骨脆性的自动、机会性监视
- 批准号:
10697573 - 财政年份:2023
- 资助金额:
$ 0.1万 - 项目类别:
Understanding how Powered Componentry Impacts K2-Level Transfemoral Amputee Gait
了解动力组件如何影响 K2 级经股截肢者步态
- 批准号:
10585944 - 财政年份:2023
- 资助金额:
$ 0.1万 - 项目类别:
Quantifying and Understanding Glaucoma Eye Drop Medication Instillation and Adherence
量化和了解青光眼滴眼剂药物滴注和依从性
- 批准号:
10338660 - 财政年份:2022
- 资助金额:
$ 0.1万 - 项目类别:
Quantifying and Understanding Glaucoma Eye Drop Medication Instillation and Adherence
量化和了解青光眼滴眼剂药物滴注和依从性
- 批准号:
10652250 - 财政年份:2022
- 资助金额:
$ 0.1万 - 项目类别:
Digital Biomarkers of Post-traumatic Osteoarthritis: Toward Precision Rehabilitation
创伤后骨关节炎的数字生物标志物:迈向精准康复
- 批准号:
10357435 - 财政年份:2022
- 资助金额:
$ 0.1万 - 项目类别: