Automated Touchscreen-Piezo Monitoring of Mouse Cognition, Activity and Sleep
自动触摸屏压电监测鼠标认知、活动和睡眠
基本信息
- 批准号:7434026
- 负责人:
- 金额:$ 20.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-06-01 至 2011-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdverse effectsAlgorithmsAlzheimer&aposs DiseaseAmnesiaAnimal BehaviorAnimalsAnxietyAutomationAwardBasic ScienceBedsBehaviorBehavior assessmentBehavioralBehavioral AssayBehavioral SciencesBenchmarkingBiological AssayBiosensorBrainChronicCircadian RhythmsClinicCognitionCognitiveComplementComputersDataData AnalysesDementiaDevelopmentDevicesDiazepamDiscriminationDiseaseEvaluationFoodFoundationsFundingGrantHome environmentHousingHuntington DiseaseImpaired cognitionLaboratoriesLearningLightLocomotionMK801MarketingMathematicsMemoryMental DepressionMental disordersMethodsMonitorMonkeysMotor ActivityMusN-MethylaspartateNIH Program AnnouncementsNerve DegenerationNeurodegenerative DisordersNeurosciencesParkinson DiseasePatientsPerformancePharmaceutical PreparationsPhasePhase II Clinical TrialsPhenotypePolysomnographyPreventive MedicineProceduresRadialRattusResearchResearch PersonnelRodentSchizophreniaSeriesSleepSleep DeprivationSleep DisordersSmall Business Funding MechanismsSmall Business Innovation Research GrantStressSystemTechniquesTechnologyTestingTherapeuticTimeTouch sensationTrainingUpper armValidationVisualWireless Technologybasebehavior testbrain behaviorcostdata acquisitiondisabilitydrinkingdrug testingengineering designgraphical user interfacehealthy volunteerhigh throughput analysishuman dataimprovedinnovationinstrumentmorris water mazemutant mouse modelneurobehaviorneurobehavioralneuropsychiatrynovelnovel strategiesprogramsprototypescale upsensorsensory gatingsoftware developmenttooltouchscreen
项目摘要
DESCRIPTION (provided by applicant): Millions of people suffer chronic neurodegeneration, leading to Alzheimer's disease and other dementias. Millions more suffer acute cognitive impairment from sleep deprivation, stress, circadian disturbances, and psychiatric disorders. Many medication side effects impair cognition, for example diazepam causing amnesia. To develop better therapies and decrease medication side effects, researchers need new testing methods and instruments. Currently, three of the most commonly used behavioral cognitive tasks, the Morris water maze, the radial-arm and the Barnes mazes in rodents primarily assess spatial memory. Since different behavioral assays always require different specialized techniques and apparatuses, researchers rarely conduct simultaneous assessments of cognition and basic neurobehaviors such as sleep, known to influence cognition. Visual discrimination using a touchscreen method, frequently used in clinics, has been adapted recently for mouse cognition assessment in Dr. Rothblat's laboratory (the co-PI). However, no standardized and automated touchscreen apparatuses for cognitive assays are commercially available. Here we propose to incorporate the touchscreen method with integrated sensor technologies to create an instrumented homecage, termed the SmartCageTM. Researchers using the SmartCage can conduct behavioral cognitive testing, and simultaneously monitor sleep and wake activity in mice at their homecages. Our Specific Aims are to: 1. Design and engineer a series of integrated circuit and microcontroller based wireless modular devices (modules) for cognitive and basic neurobehavioral assessments in a mouse homecage. These modules include the touchscreen for cognitive tasks, infrared (IR) matrices for positional and locomotor detections, and piezoelectric sensors for sleep/wake monitoring. 2. Develop a uniform graphic user interface and intuitive programs to enable automation of the touchscreen procedure, data acquisition, and integrative analysis of cognition with other neurobehaviors. 3. Evaluate the capabilities and limitations of the SmartCage by performing feasibility tests on the prototype, and benchmark tests against the original touchscreen apparatus using a mutant mouse model (rl-/+) and the NMDA antagonist MK801 known for its effects on cognition and locomotion. This versatile and habitable SmartCage will provide visual-discrimination cognitive testing and enable integration testing of cognition with other aspects of behavior, such as sleep and wake activity, thus shedding light on the interdependence of cognition and other neurobehaviors. Our novel approach is flexible, scalable, and provides a foundation for a high-throughput cognitive assay system to be developed in a Phase II study. 7. PROJECT NARRITIVE Millions of people suffer Alzheimer's disease and other dementias, yet there are no preventive medicines and effective treatments. To develop better therapies, we need better testing technology. Here we propose to develop an automated touchscreen-piezo toolkit for testing drug effects on animal learning and memory effectively, which will complement to and enhance the current cognitive assays.
描述(由申请人提供):数以百万计的人患有慢性神经退行性,导致阿尔茨海默氏病和其他痴呆症。数以百万计的人会因睡眠不足,压力,昼夜节律障碍和精神疾病而遭受急性认知障碍。许多药物副作用会损害认知,例如地西epa引起健忘症。为了开发更好的疗法并减少药物副作用,研究人员需要新的测试方法和仪器。目前,最常用的行为认知任务中的三个:啮齿动物中的莫里斯水迷宫,径向臂和巴恩斯迷宫主要评估空间记忆。由于不同的行为分析始终需要不同的专业技术和设备,因此研究人员很少对认知和基本神经行为的同时评估,例如睡眠,已知会影响认知。最近,使用触摸屏方法的视觉歧视(经常在诊所中使用)已在Rothblat博士的实验室(The Co-Pi)中进行了调整以进行小鼠认知评估。但是,没有用于认知测定的标准化和自动化的触摸屏设备。在这里,我们建议将触摸屏方法与集成的传感器技术合并,以创建一个仪器的归宿,称为SmartCagetm。使用SmartCage的研究人员可以进行行为认知测试,并同时监测小鼠在他们家中的睡眠和唤醒活动。我们的具体目的是:1。设计和设计一系列集成电路和基于微控制器的无线模块化设备(模块),用于在小鼠寄宿家庭中进行认知和基本的神经行为评估。这些模块包括用于认知任务的触摸屏,用于位置和运动检测的红外(IR)矩阵以及用于睡眠/唤醒监测的压电传感器。 2。开发一个统一的图形用户界面和直观程序,以自动化触摸屏过程,数据采集以及对认知的集成分析与其他Neurobehaviors。 3。使用突变小鼠模型(RL - /+)和NMDA拮抗剂MK801对原始触摸屏设备进行基准测试来评估SMARTCAGE的功能和局限性,并针对原始的触摸屏设备进行基准测试,并以其对认知和移动性的影响而闻名。这种多功能且可居住的SmartCage将提供视觉上歧视认知测试,并使认知与行为的其他方面(例如睡眠和唤醒活动)的整合测试,从而阐明了认知和其他神经ob的相互依存关系。我们的新方法是灵活的,可扩展的,并为在II期研究中开发的高通量认知测定系统奠定了基础。 7。叙事的项目数百万人患阿尔茨海默氏病和其他痴呆症,但没有预防药物和有效的治疗方法。为了开发更好的疗法,我们需要更好的测试技术。在这里,我们建议开发一个自动触摸屏 - piezo工具包,以有效地测试药物对动物学习和记忆的影响,这将与当前的认知测定法补充并增强。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Xinmin Simon Xie其他文献
Xinmin Simon Xie的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Xinmin Simon Xie', 18)}}的其他基金
Clinical Phase I trials on an IND single molecule dual inhibitor of Cav3 channels and soluble epoxide hydrolase for treatment of neuropathic pain
Cav3通道和可溶性环氧化物水解酶的单分子双重抑制剂治疗神经性疼痛的IND临床I期试验
- 批准号:
10760089 - 财政年份:2023
- 资助金额:
$ 20.05万 - 项目类别:
Developing a novel treatment of cocaine use disorder using an IND dual inhibitor of Cav3 channel and soluble epoxide hydrolase
使用 Cav3 通道和可溶性环氧化物水解酶的 IND 双重抑制剂开发可卡因使用障碍的新型治疗方法
- 批准号:
10786151 - 财政年份:2023
- 资助金额:
$ 20.05万 - 项目类别:
Development of a Novel Medication for Alcohol Use Disorder with an Active IND Dual Inhibitor of T-Type Calcium Channel and Soluble Epoxide Hydrolase
使用 T 型钙通道和可溶性环氧化物水解酶的活性 IND 双重抑制剂开发治疗酒精使用障碍的新型药物
- 批准号:
10815882 - 财政年份:2023
- 资助金额:
$ 20.05万 - 项目类别:
Development of selective Cav3 channel blockers for treatment of neuropathic pain
开发用于治疗神经性疼痛的选择性 Cav3 通道阻滞剂
- 批准号:
8779431 - 财政年份:2014
- 资助金额:
$ 20.05万 - 项目类别:
Development of selective Cav3 channel blockers for treatment of neuropathic pain
开发用于治疗神经性疼痛的选择性 Cav3 通道阻滞剂
- 批准号:
9136310 - 财政年份:2014
- 资助金额:
$ 20.05万 - 项目类别:
Development of selective Cav3 channel blockers for treatment of neuropathic pain
开发用于治疗神经性疼痛的选择性 Cav3 通道阻滞剂
- 批准号:
9143175 - 财政年份:2014
- 资助金额:
$ 20.05万 - 项目类别:
Development of patented tricyclic pyrones molecules for the treatment of Alzheimer’s Disease
开发用于治疗阿尔茨海默病的专利三环吡喃酮分子
- 批准号:
9442675 - 财政年份:2013
- 资助金额:
$ 20.05万 - 项目类别:
Development of patented tricyclic pyrones molecules for the treatment of Alzheimer’s Disease
开发用于治疗阿尔茨海默病的专利三环吡喃酮分子
- 批准号:
9744038 - 财政年份:2013
- 资助金额:
$ 20.05万 - 项目类别:
Development of Novel Tricyclic Pyrone Drugs for Treatment of Alzheimer Disease
治疗阿尔茨海默病的新型三环吡喃酮药物的开发
- 批准号:
8516617 - 财政年份:2013
- 资助金额:
$ 20.05万 - 项目类别:
Development of Novel Tricyclic Pyrone Drugs for Treatment of Alzheimer Disease
治疗阿尔茨海默病的新型三环吡喃酮药物的开发
- 批准号:
8681291 - 财政年份:2013
- 资助金额:
$ 20.05万 - 项目类别:
相似国自然基金
基因与家庭不利环境影响儿童反社会行为的表观遗传机制:一项追踪研究
- 批准号:
- 批准年份:2020
- 资助金额:58 万元
- 项目类别:面上项目
不利地质结构对地下洞室群围岩地震响应影响研究
- 批准号:51009131
- 批准年份:2010
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
列车制动力对铁路桥梁的作用机理及最不利影响的研究
- 批准号:50178004
- 批准年份:2001
- 资助金额:23.0 万元
- 项目类别:面上项目
相似海外基金
Traumatic Brain Injury Anti-Seizure Prophylaxis in the Medicare Program
医疗保险计划中的创伤性脑损伤抗癫痫预防
- 批准号:
10715238 - 财政年份:2023
- 资助金额:
$ 20.05万 - 项目类别:
Leveraging Automated Optimization of Inspired Oxygen and Oxidized Biomarker Lipidomics for Targeted Oxygenation during Mechanical Ventilation: a Pragmatic Clinical Trial
利用吸入氧和氧化生物标志物脂质组学的自动优化在机械通气期间进行靶向氧合:一项实用的临床试验
- 批准号:
10592000 - 财政年份:2023
- 资助金额:
$ 20.05万 - 项目类别:
PA TH2Caregiving: Data-Driven Digital Engagement to Assess and Address the Needs of Family Caregivers
PA TH2Caregiving:数据驱动的数字参与,评估和满足家庭护理人员的需求
- 批准号:
10598028 - 财政年份:2023
- 资助金额:
$ 20.05万 - 项目类别:
1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)
1/4-破译ECT结果和不良反应的机制(DECODE)
- 批准号:
10521849 - 财政年份:2022
- 资助金额:
$ 20.05万 - 项目类别:
Modeling Multi-Source Data in Hodgkin Lymphoma
霍奇金淋巴瘤的多源数据建模
- 批准号:
10579326 - 财政年份:2022
- 资助金额:
$ 20.05万 - 项目类别: