HYPR-Spectral PCT for Preclinical Imaging

用于临床前成像的 HYPR-Spectral PCT

• 批准号: 7534898
• 负责人: ROBERT A KRUGER
• 金额: $ 19.39万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7534898
• 关键词: 3-Dimensional; Acceleration; Algorithms; Angiogenesis Inhibitors; Animals; Blood flow; Caliber; Data; Devices; Disease; Disease Progression; Engineering; Goals; Hemoglobin; Hypoxia; Image; Imaging Device; Infrared Rays; Institution; Magnetic Resonance Angiography; Malignant Neoplasms; Measures; Modeling; Molecular Probes; Molecular Structure; Monitor; Mus; Noise; Pharmacologic Substance; Phase; Polychloroterphenyl Compounds; Prevention, Clinical, and Therapeutic Subcommittee; Process; Public Health; Radial; Research Personnel; Research Project Grants; Resolution; Scientist; Signal Transduction; Surface; Techniques; Therapeutic; Tissues; Xenograft procedure; data acquisition; design; design and construction; improved; in vivo; instrumentation; mouse model; novel; pre-clinical; reconstruction; response; tissue oxygenation; tumor

DESCRIPTION (provided by applicant): The long-term objective of this research project is to develop instrumentation and accelerated reconstruction techniques that will allow researchers to measure in vivo the heterogeneous hypoxic microenvironment of tumor models grown in mice, both xenografts and genetically engineered. To achieve these goals we will evaluate a new photoacoustic CT scanner designed to take advantage of acceleration techniques recently developed for phase contrast magnetic resonance angiography (MRA) and dynamic contrast enhanced MRA (DCE-MRA), which can significantly improve temporal resolution, without sacrificing signal to noise or spatial resolution. In Phase I we will design, construct and evaluate a new PCT scanner that will acquire a sparse set of 128 "projections" uniformly distributed over the surface of a hemisphere. Our goals are to achieve sub-second temporal resolution for dynamic studies and to acquire spectroscopic data over 16 wavelengths in as little as 1.6 seconds throughout a 20-mm-diameter imaging volume. Should we succeed, we will apply these techniques in vivo to mouse models of cancer in Phase II. PUBLIC HEALTH RELEVANCE: Scientists at pharmaceutical companies and academic institutions routinely employ preclinical imaging of small animals, especially mice, to study disease progression and monitor response to therapies. We propose to develop a novel, photoacoustic-imaging device that would allow researchers to interrogate the molecular structure of disease and assess response to therapy in a preclinical setting using near infrared radiation. This device would allow researchers to quantify hemoglobin concentration, blood flow, tissue oxygenation, and the accumulation of molecular probes in targeted tissues in small animals with excellent 3-D spatial and temporal resolution.

描述（由申请人提供）：该研究项目的长期目标是开发仪器和加速重建技术，使研究人员能够在体内测量小鼠肿瘤模型（异种移植和基因工程模型）的异质缺氧微环境。为了实现这些目标，我们将评估一种新型光声 CT 扫描仪，该扫描仪旨在利用最近为相衬磁共振血管造影 (MRA) 和动态对比增强 MRA (DCE-MRA) 开发的加速技术，该技术可以显着提高时间分辨率，而无需牺牲时间分辨率。信噪比或空间分辨率。在第一阶段，我们将设计、构建和评估一种新的 PCT 扫描仪，该扫描仪将采集均匀分布在半球表面的 128 个稀疏“投影”集。我们的目标是实现动态研究的亚秒级时间分辨率，并在短短 1.6 秒内获取整个 20 毫米直径成像体积中 16 个波长的光谱数据。如果我们成功，我们将在第二阶段将这些技术应用于体内癌症小鼠模型。公共卫生相关性：制药公司和学术机构的科学家通常采用小动物（尤其是小鼠）的临床前成像来研究疾病进展并监测对治疗的反应。我们建议开发一种新型光声成像设备，使研究人员能够利用近红外辐射探究疾病的分子结构并评估临床前环境中对治疗的反应。该设备将使研究人员能够以出色的 3D 空间和时间分辨率来量化小动物目标组织中的血红蛋白浓度、血流量、组织氧合和分子探针的积累。