SWAN-Study of Women's Health Across the Nation-N.J.site

SWAN-全国妇女健康研究-新泽西州网站

• 批准号: 7418220
• 负责人: Nanette F. Santoro
• 金额: $ 36.1万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7418220
• 关键词: Address; Affect; African American; Age; Aging; Androgens; Area; Behavioral Symptoms; Biological; Biological Markers; Biology; Blood; Blood Pressure; Blood Vessels; Body Composition; Body Size; Bone Density; Cardiovascular Diseases; Cardiovascular system; Caucasians; Caucasoid Race; Characteristics; Chinese People; Chronic Disease; Class; Clinic Visits; Clinical; Cognitive; Communities; Complementary and alternative medicine; DEXA; DNA; Daily; Data; Data Collection; Dementia; Diabetes Mellitus; Disease; Doctor of Medicine; End Point; Enrollment; Ensure; Environment; Estrogens; Ethnic Origin; Ethnic group; Evaluation; Event; Foundations; Fracture; Funding; Future; Goals; Grant; Health; Hemorrhage; Hispanics; Hormonal; Hormones; Hypertension; Impaired cognition; Incidence; Institutes; Japanese Population; Laboratories; Lead; Leadership; Life; Life Style; Link; Longitudinal Studies; Mails; Maintenance; Measurement; Menopause; Menstruation; Moods; National Institute of Nursing Research; Operative Surgical Procedures; Outcome; Participant; Pathologic Processes; Pattern; Perimenopause; Personal Satisfaction; Phase Transition; Physiological; Physiological Processes; Plasma; Postmenopause; Premenopause; Prevention strategy; Productivity; Psychosocial Factor; Publishing; Questionnaires; Randomized; Range; Recording of previous events; Relative (related person); Request for Applications; Research; Research Design; Risk; Risk Factors; Sampling; Schedule; Sex Functioning; Site; Smoker; Specimen; Staging; Stroke; Subgroup; Survival Analysis; Symptoms; Technology; Telephone; Testing; Thromboembolism; Time; U-Series Cooperative Agreements; Urinary Incontinence; Urine; Variant; Vasomotor; Visit; Woman; Women' s Health; age related; aged; base; bone; bone loss; cardiovascular disorder risk; cardiovascular risk factor; cognitive function; cohort; cost; critical developmental period; design; experience; follow-up; hormone therapy; immortalized cell; improved; malignant breast neoplasm; middle age; morphometry; psychologic; psychosocial; racial/ethnic difference; repository; reproductive hormone; response; socioeconomics; spine bone structure

DESCRIPTION (provided by applicant): The Study of Women's Health Across the Nation (SWAN) is a multicenter, multiethnic, community based longitudinal study designed to characterize the biological, symptomatic and psychosocial changes that occur during the menopausal transition and the effects of these changes on women's health during and after the transition. Current and prior funding (SWAN I and II) has supported a baseline and six annual follow-up examinations during which 895 (48%) women will have transitioned to postmenopause. This application requests funding to complete four additional follow-up visits (SWAN III) to allow an adequate evaluation of the late perimenopause and early postmenopause, a period that has not been well studied, particularly among non-white women. We will continue our current tracking of changes in reproductive hormones, bleeding patterns, symptoms, bone loss, cardiovascular (CV) risk factors blood pressure, body size, and other related characteristics and will undertake new scientific endeavors in targeted areas. These include measurement of vascular stiffness to assess early CV disease, assessment of vertebral morphometry at four sites using DEXA technology, and the addition of one cognitive function test. In addition, we will focus on linking the midlife experience to age-related outcomes (e.g. cognitive function, urinary incontinence) and chronic diseases (e.g. fractures, diabetes and hypertension). Specimens from the additional follow-up visits will continue to contribute to the SWAN biological specimen repository (annual blood and urine samples as well as DNA and immortalized cells). This is a separately funded component that broadens the opportunities to address future hypotheses about health and disease in aging women. As women reach the end of early postmenopause (two years following the final menstrual period), we will shift from an annual to a bi-annual follow-up examination schedule with mail and telephone contact in the alternating years. This will permit cost-effective and less intensive follow-up. SWAN's organization and operations have been modified to enhance productivity and we are poised to publish important biological, symptom and behavioral results pertaining to the menopause transition. With SWAN III, many of the original goals of SWAN will be brought to fruition. We will build upon the rich foundation developed during SWAN I and II and link these data to important menopauserelated and health outcomes in SWAN III.

描述（由申请人提供）：全国妇女健康（SWAN）的研究是一项多中心，基于社区的纵向纵向研究，旨在表征更年期过渡期间的生物学，症状和心理社会变化，以及这些变化对过渡期间妇女健康的影响。当前和先前的资金（天鹅I和II）支持了基线和六次年度随访考试，在此期间，有895名（48％）妇女将过渡到绝经后。该申请要求资金完成四次额外的后续访问（天鹅III），以允许对上期晚期和绝经后早期进行足够的评估，这一时期尚未得到很好的研究，尤其是在非白人妇女中。我们将继续跟踪当前对生殖激素，出血模式，症状，骨质流失，心血管（CV）风险因素血压，体型和其他相关相关的危险变化的跟踪 特征并将在目标地区进行新的科学努力。这些包括测量血管僵硬以评估早期CV疾病，使用DEXA技术在四个位点评估椎骨形态计的评估，以及添加一个认知功能测试。此外，我们将专注于将中年经验与年龄相关的结果（例如认知功能，尿失禁）和慢性疾病（例如骨折，糖尿病和高血压）联系起来。额外的随访访问中的标本将继续有助于天鹅生物学标本存储库（每年的血液和尿液样品以及DNA和永生细胞）。这是一个单独资助的组成部分，它扩大了解决妇女衰老妇女健康和疾病的未来假设的机会。随着妇女在绝经后早期结束（最后的月经后两年），我们将在交替的年份从年度的邮件和电话联系。这将允许具有成本效益且较少密集的随访。天鹅的组织和运营已被修改以提高生产率，我们准备出版与更年期有关的重要生物学，症状和行为结果 过渡。有了天鹅三世，天鹅的许多最初目标将实现。我们将建造 在天鹅I和II期间发展的丰富基础上，这些数据与天鹅III的重要更年期和健康成果联系起来。