SWAN Repository

天鹅存储库

• 批准号: 7433243
• 负责人: MARYFRAN R SOWERS
• 金额: $ 91.57万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433243
• 关键词: Area; Awareness; Biological; Cells; Clinic; Communication; Communities; DNA; Daily; Data; Data Analyses; Databases; Development; Equilibrium; Ethics; Ethnic group; Funding; Genetic; Genomics; Goals; Hormones; Individual; Knowledge; Laboratories; Link; Longitudinal Studies; Lymphocyte; Maintenance; Measurement; Menopause; Menstrual cycle; Parents; Participant; Plasma; Policies; Population; Proteomics; Race; Research; Research Infrastructure; Resources; Rights; Sampling; Science; Scientist; Serum; Services; Source; Specimen; Urine; Woman; Women' s Health; adjudication; base; cell transformation; data management; design; follow-up; immortalized cell; programs; racial and ethnic; repository

DESCRIPTION (provided by applicant): This application is to provide for the continued implementation of a Repository of serum, plasma, urine, DNA and transformed b-lymphocytes generated from the SWAN population of women transitioning the menopause. The initial five years of Repository funding was focused on coalescing specimens from clinics and laboratories (now more than 950,000 specimens), building a DNA Repository (which now includes DNA as well as immortalized cells from more than 1700 participants), and building the infrastructure to begin developing new data from Repository specimens. The proposed funding will sustain these biological specimens, support the integration of additional specimens from the next 3 rounds of the parent SWAN program, link specimens to already collected data (7 years currently), provide a mechanism for developing new information from these specimens, and make the newly developed data from the Repository available to the scientific community. In addition to extending the previous activities, new aims of this application are to 1) support more extensive use of the Repository resources by promoting the awareness of the specimens and the availability of specimens to scientists, optimizing the adjudication of resource utilization and developing a plan for the ongoing maintenance of the Repository functions at the end of the proposed funding period. 2) develop and sustain ethics/public service activities as well as quantitative capacity for development of new science from the specimens. This will include a statistical genetics consultant (Dr. Sharon Kardia) to facilitate the extended use of genetics data and a biostatistical consultant (Dr. Sybil Crawford) to support longitudinal analyses specifically for the specimens from the longitudinal Daily Hormone Study (i.e, monthly longitudinal studies nested within a 6-year longitudinal study). Funding this Repository will allow the ongoing maintenance and utilization of the already collected specimens for the greater scientific community, provide for the incorporation of specimens from SWAN III Follow-ups 8-10, and build an independent research resource through transformed cells and their derived products as well as from the data developed from using Repository specimens.

描述（由申请人提供）：此应用程序是为了继续实施血清，等离子体，尿液，DNA和转化的B淋巴细胞的存储库，该存储量是由从过渡更年期过渡的妇女人群产生的。最初 五年的存储库资金集中于从诊所和实验室（现在超过950,000个标本）中融合标本，建造一个DNA存储库（现在包括DNA以及1700多名参与者的永生细胞），并构建基础设施以开始从repository标本开发新数据的基础设施。拟议的资金将维持这些生物标本，支持由父母天鹅计划的接下来3轮中的其他标本的整合，将标本链接到已经收集的数据（目前为7年），提供了一种从这些标本中开发新信息的机制，并从这些标本中开发了新开发的数据，并从 存储库科学界可用。 除了扩展先前的活动外，该应用程序的新目标是1）通过提高标本的认识以及对科学家的可用性的可用性来支持更多的存储库资源，优化了资源利用的裁决并制定计划，以在拟议的资助期间的持续维护库中维护库存库的持续维护。 2）开发和维持道德/公共服务活动以及从标本开发新科学的定量能力。这将包括统计遗传学 顾问（Sharon Kardia博士）旨在促进遗传学数据的扩展使用和生物统计学顾问（Sybil Crawford博士），以支持专门针对纵向每日激素研究的标本（即每月的纵向研究中筑巢的纵向纵向研究）的纵向分析。 资助该存储库的资金将允许持续维护和利用已经收集的更大科学界的标本，规定从Swan III随访8-10的标本中纳入标本，并通过使用存储库标本的数据从转换的细胞及其派生的细胞以及数据来建立独立的研究资源。