Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT

用于平板锥形束 CT 中骨微结构成像的新型高分辨率闪烁体

基本信息

批准号：
9555332
负责人：
VIVEK V NAGARKAR
金额：
$ 21.68万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9555332
关键词：
Ablation Address Adult Area Attenuated BMP7 gene Biological Markers Blood Vessels Bone Density Breast Clinical Collaborations Collection Complement Complex Data Degenerative polyarthritis Dental Deposition Detection Development Disease Distal Doctor of Medicine Dose Early Diagnosis Electronics Ensure Etiology Evaluation Film Future Growth Health Healthcare Hip Fractures Hip region structure Housing Human Image Imagery Intervention Joints Lasers Lateral Letters Light Limb structure Logistics Measurement Measures Modification Monitor Morphology Musculoskeletal Diseases Names Nature Noise Orthopedics Osteoporosis Pathologic Performance Phase Process Property Radiation Resolution Roentgen Rays Signal Transduction Silicon Site Source Staging Stents Structure System Techniques Technology Temporal bone structure Testing Theoretical model Thick Three-Dimensional Imaging Translations Universities Vertebral column Weight-Bearing state Work X-Ray Computed Tomography absorption arm attenuation base bone bone imaging bone quality calcification cartilage degradation clinical imaging commercialization cone-beam computed tomography cortical bone crystallinity detector experience fracture risk image guided imaging modality imaging platform imaging system improved in vivo innovation maxillofacial middle ear novel programs prototype quantitative imaging quantum sensor substantia spongiosa treatment response vapor

项目摘要

Abstract Pathological changes in bone microarchitecture are associated with a broad range of musculoskeletal (MSK) diseases, including osteoporosis (OP) and osteoarthritis (OA). OP and OA carry significant healthcare burden, with an estimated 10 million US adults suffering from OP and 27 million afflicted by OA. This motivates quantitative assessment of bone microstructure on clinical imaging systems. Quantitative metrics of bone microarchitecture remain, however, underutilized in OP and OA because of limited spatial resolution of current orthopedic imaging modalities. Application of extremity CBCT in quantitative imaging of bone microstructure is likely to have high impact in OA and OP because (a) OA occurs primarily in the extremities, and (b) in OP, morphological measurements in distal extremities were shown to be indicative of fracture risk, including of hip fractures. Again, the spatial resolution of current extremity CBCT (≥0.25 mm) is insufficient to fully resolve the ≤0.1 mm trabeculae, limiting the performance in assessment of bone quality. We intend to address this specific issue through the development of a novel sensor that promises to provide the necessary resolution without compromising detector sensitivity. Efficacy of such a detector will be demonstrated through CBCT scanning and comparing results to those obtained using the current state-of-the-art system.

抽象的骨微结构的病理变化与广泛的肌肉骨骼 (MSK) 疾病，包括骨质疏松症 (OP) 和骨关节炎 (OA)。巨大的医疗负担，估计有 1000 万美国成年人患有 OP，2700 万美国成年人患有 OP 受 OA 的影响，这促使临床影像学上对骨微观结构进行定量评估。然而，骨微结构的定量指标在 OP 和 OA 中仍未得到充分利用。由于当前骨科成像模式的空间分辨率有限。 CBCT 在骨微结构定量成像中可能对 OA 和 OP 产生重大影响，因为 (a) OA 主要发生在四肢，(b) OP，远端四肢的形态测量被证明可以指示骨折风险，包括髋部骨折的空间分辨率。目前的肢体 CBCT（≥0.25 mm）不足以完全分辨 ≤0.1 mm 的小梁，限制了我们打算通过骨质量评估来解决这个具体问题。开发一种新型传感器，有望在不影响分辨率的情况下提供必要的分辨率探测器的灵敏度将通过 CBCT 扫描和验证来证明。将结果与使用当前最先进系统获得的结果进行比较。