MULTICENTER AIDS COHORT STUDY

多中心艾滋病队列研究

• 批准号: 7408644
• 负责人: CHARLES R RINALDO
• 金额: $ 339.39万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-03 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7408644
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adherence; Adverse effects; African American; Aging; Anti-Retroviral Agents; Behavior Therapy; Biological; CD4 Positive T Lymphocytes; Cardiovascular Diseases; Cardiovascular system; Cell Count; Clinical; Cohort Studies; Companions; Data; Diabetes Mellitus; Disease; Dyslipidemias; Electrocardiogram; Electron Beam Tomography; Enrollment; Ethnic Origin; Glucose; Goals; HIV; HIV Infections; HIV Seropositivity; HIV drug resistance; Hepatitis B Virus; Hepatitis C virus; Highly Active Antiretroviral Therapy; Human immunodeficiency virus test; Incidence; Individual; Insulin; Intervention; Laboratories; Link; Lipids; Lipodystrophy; Liver Function Tests; Longitudinal Studies; Maintenance; Natural History; Outcome; Participant; Pathogenesis; Pattern; Persons; Population; Prevalence; Race; Recording of previous events; Recruitment Activity; Risk Behaviors; Sampling; Serum; Site; Specimen; Staging; Surrogate Markers; T-Lymphocyte Subsets; Testing; Thick; Time; Treatment Efficacy; Treatment Protocols; U-Series Cooperative Agreements; Viral Load result; cardiovascular disorder risk; cohort; expectation; follow-up; improved; intima media; men; men who have sex with men; nutrition; repository; therapy duration; transmission process; trend

DESCRIPTION (provided by applicant): This application is Part B of a proposal for a competing renewal of the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1UO1-AI-35041), the companion to the Part A composite proposal that is being submitted by CAMACS. This request is for an additional five years of support for clinical follow-up and laboratory testing of the original and recently recruited cohort of MSM in the Pittsburgh MACS. The current priority of the MACS is to enhance our epidemiologic and pathogenesis information in relation to treatment intervention. We need to describe the long-term patterns of therapy use that are consequential in terms of treatment efficacy. Our specific aims emphasize cohort retention and maintenance, biological specimen procurement and central lipid/insulin/glucose testing for dyslipidemia, diabetes, lipodystrophy and cardiovascular disease for the MACS. These are: (1) To characterize the evolving natural history of treated HIV infection and identify the determinants and trends of long-term HIV-related outcomes in the era of HAART. We will determine the effect of anti-retroviral therapies on disease incidence, surrogate markers and survival expectation. This includes special emphasis on our recently expanded cohort of young, African-American MSM, who were underrepresented in the original MACS cohort, yet maintain an inordinately greater prevalence of HIV infection in the USA. (2) To maintain the longitudinally collected epidemiological data and biological specimen repository framework of the Pittsburgh MACS as a platform to facilitate natural history and pathogenesis studies. (3) To perform the required clinical and laboratory testing of HIV seropositive and seronegative MSM in the Pittsburgh MACS. (4) To perform cardiovascular testing (Electron Beam Computed Tomography [EBCT], carotid intima media thickness [IMT], and EKG testing) on a sub-sample of the MACS to address key questions related to risk of cardiovascular disease among HAART recipients. We believe that through these aims, as well as through substudies on the immunopathogenesis of HIV infection that are closely linked to the Pittsburgh MACS, we will significantly contribute to the scientific agenda and goals of the MACS.

描述（由申请人提供）： 该申请是对多中心艾滋病队列研究（MACS）合作协议（1UO1-35041）的匹兹堡组成部分进行竞争续订的提案的B部分，这是该部分的综合建议，该综合提案是由Camacs提交的。 该请求是对匹兹堡Mac中原始和最近招募的MSM队列的临床随访和实验室测试的五年支持。 MAC的当前优先级是增强与治疗干预有关的流行病学和发病机理。我们需要描述治疗效果方面的长期治疗使用模式。我们的具体目的强调了队列保留和维持，生物标本采购以及中央脂质/胰岛素/葡萄糖测试，用于血脂异常，糖尿病，脂肪营养不良和心脏血管疾病。这些是：（1）表征治疗的艾滋病毒感染的自然历史，并确定HAART时代长期与HIV相关结果的决定因素和趋势。 我们将确定抗逆转录病毒疗法对疾病发病率，替代标记和生存的影响 期待。这特别强调了我们最近扩展的年轻非裔美国人MSM的同类，这些MSM在原始Macs队列中的人数不足，但在美国的HIV感染率越来越大。 （2）将匹兹堡Mac的纵向收集的流行病学数据和生物标本存储库框架作为促进自然历史和发病机理研究的平台。 （3）在匹兹堡MAC中，对HIV血清阳性和血清质MSM进行所需的临床和实验室测试。 （4）在MAC的子样本上进行心血管测试（电子束计算机断层扫描[EBCT]，颈动脉内膜培养基厚度[IMT]和EKG测试），以解决与Haart接受者中与心血管疾病风险有关的关键问题。 我们认为，通过这些目的以及通过与匹兹堡MAC密切相关的HIV感染的免疫发病发生的物质，我们将为MAC的科学议程和目标做出重大贡献。