In vivo derived in silico model for DDS optimization

用于 DDS 优化的体内计算机模型

• 批准号: 9127202
• 负责人: Dieter Haemmerich
• 金额: $ 12.54万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127202
• 关键词: 3-Dimensional; Adverse effects; Affect; Animals; Applications Grants; Area; Bioavailable; Biodistribution; Biological; Biological Availability; Blood Vessels; Blood flow; Cells; Complex; Computer Simulation; Data; Development; Devices; Dose; Doxorubicin Hydrochloride Liposome; Drug Carriers; Drug Delivery Systems; Drug Transport; Engineering; Evaluation; Extravasation; Formulation; Goals; Growth; Half-Life; Health; Heating; Heterogeneity; High Pressure Liquid Chromatography; Human; Hyperthermia; Image Analysis; In Vitro; Kinetics; Liposomes; Maps; Measurement; Measures; Methods; Modeling; Modification; Penetration; Perfusion; Pharmaceutical Preparations; Physiological; Physiology; Plasma; Property; Regimen; Site; Solid Neoplasm; System; Technology; Temperature; Testing; Therapeutic Index; Tissue Sample; Tissues; Toxic effect; Tumor Biology; Tumor-Derived; Validation; Vascular Permeabilities; Work; base; chemotherapy; contrast enhanced; density; design; essays; feeding; imaging modality; improved; in vivo; intravital fluorescence microscopy; liposomal delivery; liposome vector; method development; model design; nanoparticle; neoplastic cell; novel; novel strategies; novel therapeutics; quantitative imaging; temporal measurement; three-dimensional modeling; tumor; uptake

DESCRIPTION (provided by applicant): There are limited quantitative methods to aid systematic design and development of drug delivery systems. We have developed a computational model that predicts the amount of drug that is delivered to the tumor, and we were able to make relevant predictions for ideal properties of liposomes from our models. The first goal of this grant application is the development of methods to measure tumor transport properties in vivo. The model is then validated, and will serve as platform for optimization of heat-activated liposomal carriers. The proposed approach thus aids the development of more effective drug delivery systems, and has general applicability for various drug delivery systems.

描述（由申请人提供）：帮助系统设计和开发药物输送系统的定量方法有限。我们开发了一种计算模型，可以预测输送到肿瘤的药物量，并且我们能够从我们的模型中对脂质体的理想特性做出相关预测。该拨款申请的首要目标是开发测量体内肿瘤转运特性的方法。然后对该模型进行验证，并将作为热激活脂质体载体优化的平台。因此，所提出的方法有助于开发更有效的药物递送系统，并且具有对各种药物递送系统的普遍适用性。