Epidemiology of Dementia in Cache County, Utah

犹他州卡什县痴呆症流行病学

• 批准号: 7666391
• 负责人: KATHLEEN Anne WELSH-BOHMER
• 金额: $ 19.9万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7666391
• 关键词: Age; Aged, 80 and over; Alzheimer' s Disease; Alzheimer' s disease risk; Antioxidants; Apolipoprotein E; Attention; Autopsy; Categories; Characteristics; Cognitive; County; Data; Dementia; Development; Diagnosis; Elderly; Environmental Risk Factor; Epidemiology; Exposure to; Genetic; Genotype; Hormone replacement therapy; Impaired cognition; Impairment; Incidence; Individual; Intervention; Investigation; Leadership; Nature; Neuroprotective Agents; Non-Steroidal Anti-Inflammatory Agents; Onset of illness; Outcome; Participant; Phase; Population; Prevalence; Principal Investigator; Rate; Research Personnel; Risk Factors; Sampling; Screening procedure; Staging; Testing; Time; Utah; Vitamins; Work; base; cognitive change; cognitive function; cohort; gene environment interaction; genetic risk factor; interest; mild neurocognitive impairment; pre-clinical; programs; prospective; time interval

Established in 1994, the Cache County Study is a population-based longitudinal investigation of dementia in relation to genetic and environmental antecedents. The renewal of this important work will capitalize on nine years of prospective observation in this epidemiological cohort and will have available longitudinal cognitive assessments in the entire sample. Using these observations, we will empirically define the early cognitive trajectory of preclinical Alzheimer's disease (AD) and the relationship of antecedent exposures to the rate of decline and to categorical outcomes of dementia. There are four major specific aims of the project, which are as follows: 1. Conduct two more triennial waves of screening (Waves 3 and 4) among Cache County residents not demented at prior screenings. Use the nine years of observation to examine the trajectory of cognitive change to dementia and to obtain more precise estimates of the incidence of AD, especially after age 85. 2. Use an expanded cognitive screening battery for proposed Waves 3 and 4. Examine the efficiency of the new battery as a screen for dementia. Also, use the resulting expanded information base to extend existing data on trajectory of cognitive functioning to a nine-year time interval. With this new information, examine: a) Individual (cross sectional) features of cognitive dysfunction, or clusters of such features, that most strongly predict subsequent development of dementia; b) Nature and extent of change in such features or their clusters over time, including specifically a search for changes that most strongly predict the development of dementia; c) Various operationally defined categories of cognitive impairment (e.g., "Mild Cognitive Impairment" [MCI], etc.) and compare their abilities to predict subsequent dementia. 3. Extend prior studies of the influence of genetic and environmental factors on risk of AD, noting whether these same factors predict tragectory of cognitive decline as a prodrome of AD. 4. Continue and extend the study's existing autopsy program, expanding its aims to clinically diagnosed dementia subtypes and to unaffected participants, particularly those with risk factors for dementia (age 85+, MCI).

Cache County研究成立于1994年，是一项基于人群的痴呆症与遗传和环境先例有关的纵向研究。 这项重要工作的续签将利用这一流行病学队列的9年前瞻性观察，并将在整个样本中提供纵向认知评估。 使用这些观察结果，我们将凭经验定义临床前阿尔茨海默氏病（AD）的早期认知轨迹，以及前期暴露与下降率和痴呆症的分类结果的关系。 该项目有四个主要的特定目的，如下：1。在先前筛查中未痴呆的卡ache县居民中，再进行两次筛查（波3和4）。使用九年的观察来检查痴呆症认知变化的轨迹，并获得对AD发生率的更精确的估计值，尤其是在85岁之后。2。使用扩展的认知筛选电池，以进行拟议的波3和4。检查新电池的效率作为新电池作为痴呆症的筛查。 另外，使用由此产生的扩展信息库将有关认知功能轨迹的现有数据扩展到九年的时间间隔。 有了这些新信息，请检查：a）认知功能障碍的个体（横截面）特征，或这些特征的簇，最强烈预测随后的痴呆症的发展； b）随着时间的推移，这种特征或其簇的变化的性质和程度，包括特别是对最强烈预测痴呆症发展的变化的搜索； c）各种操作定义的认知障碍类别（例如，“轻度认知障碍” [MCI]等），并比较了他们预测随后痴呆症的能力。 3.扩展了对遗传和环境因素对AD风险的影响的先前研究，并指出这些相同的因素是否可以预测认知能力下降的悲惨视为是AD的前代。 4。继续并扩展该研究的现有尸检计划，将其目标扩展到临床诊断的痴呆症亚型和未受影响的参与者，尤其是那些患有痴呆症风险因素的参与者（85岁以上，MCI）。