Meta-Analysis of Male Sexual Orientation

男性性取向的荟萃分析

• 批准号: 9357379
• 负责人: Eden R. Martin
• 金额: $ 19.31万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9357379
• 关键词: Address; Affect; Alleles; Area; Attention; Basic Science; Behavior; Biocompatible Materials; Biological; Biology; Brain; Characteristics; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 8; Complex; DNA; Data; Databases; Detection; Development; Environmental Risk Factor; Etiology; European; Event; Family; Family Study; Funding; Future; Genetic; Genetic study; Goals; Heritability; Heterosexuality; Heterosexuals; Homosexuality; Homosexuals; Human; Individual; Journals; Knowledge; Learning; Letters; Life; Maps; Meta-Analysis; Mind; Minority; Molecular; Molecular Genetics; Nature; Phenotype; Publishing; Reporting; Research; Resources; Sample Size; Sampling; Science; Sex Behavior; Sex Chromosomes; Sex Orientation; Sexual Development; Sexuality; Siblings; Societies; Statistical Data Interpretation; Surface; Twin Studies; Variant; Woman; Work; brain behavior; database of Genotypes and Phenotypes; genetic linkage; genetic variant; genome wide association study; genome-wide; genome-wide analysis; genome-wide linkage; genotyping technology; interest; male; meetings; men; posters; public health relevance; sample collection; segregation; social; trait; willingness

 DESCRIPTION (provided by applicant): This project will provide the most comprehensive study to date on the genetics of male sexual orientation. The main justifications for basic research on the etiology and development of sexual orientation include that it carries much social importance and interest, and that such research will illuminate sexual characteristics of brain, mind and behavior, thus informing society about currently unknown biological aspects behind male sexual orientation. Male sexual orientation is known to be heritable, but is multifactorial in nature with multiple genetic and environmental factors contributing to its etiology. Genetic linkage studies have found strong evidence of specific genetic loci (pericentromeric chromosome 8 and chromosome Xq28). Genome-wide association studies (GWAS) for sexual orientation are only just beginning to surface. There is a great need to combine studies to elucidate the genetics of this important biological trait. In this proposal, we plan to conduct meta-analysis of several genome-wide linkage studies (GWLS) and GWAS to maximize the ability to identify genetic targets for future study. Our specific aims are as follows 1. Determine the most promising linkage regions by meta-analyzing GWLS for male sexual orientation: our own GWLS of 409 ASPs, plus other collaborative GWLS of 155 ASPs, totaling 564 ASPs (representing 91% of the field's ASPs). 2. Conduct a meta-analysis of available GWAS for male sexual orientation using our European ancestry (EA) GWAS of 701 homosexual and 1,214 heterosexual men, plus other collaborative GWAS, en masse currently totaling 5,752 homosexual and 39,286 heterosexual men, and growing. Our results will be instrumental to a better understanding of the genetic contributions to male sexual orientation and also enable future approaches aimed at locating genetic variants contributing to trait variation, especially re sequencing. Finding linkage, association, or eventually contributory genetic variants will open a gateway to additional research that will inform the study of genetic and environmental mechanisms and developmental events influencing sexual orientation.

 描述（由申请人提供）：该项目将提供迄今为止关于男性性取向遗传学的最全面的研究。对性取向的病因学和发展进行基础研究的主要理由包括它具有很大的社会重要性和兴趣，以及此类研究将阐明大脑、思想和行为的性特征，从而让社会了解男性性取向背后目前未知的生物学方面。已知男性性取向是可遗传的，但本质上是多因素的，多种遗传和环境因素导致其发生。遗传连锁研究已经发现了特定遗传位点（着丝粒周围 8 号染色体和 Xq28 号染色体）的有力证据，关于性取向的全基因组关联研究 (GWAS) 才刚刚开始浮出水面，迫切需要结合研究来阐明。在本提案中，我们计划对多项全基因组连锁研究（GWLS）和 GWAS 进行荟萃分析，以最大限度地提高遗传识别未来研究目标的能力。 1. 通过对男性性取向的 GWLS 进行荟萃分析，确定最有希望的连锁区域：我们自己的 GWLS 为 409 个 ASP，加上其他合作的 GWLS 为 155 个 ASP，总共 564 个 ASP（占该领域 ASP 的 91%）2。使用我们的欧洲血统 (EA) GWAS 对男性性取向的可用 GWAS 进行荟萃分析701 名同性恋和 1,214 名异性恋男性，加上其他合作 GWAS，目前总共有 5,752 名同性恋和 39,286 名异性恋男性，并且这一结果将有助于更好地了解遗传对男性性取向的影响，也使未来的方法能够针对男性性取向。定位导致性状变异的遗传变异，尤其是基因变异 寻找连锁、关联或最终有贡献的遗传变异将为进一步研究打开大门，为影响性取向的遗传和环境机制以及发育事件的研究提供信息。