New psychoactive substance exposure among NYC nightclub and festival attendees

纽约夜总会和节日参加者接触新的精神活性物质

基本信息

批准号：
10734617
负责人：
Joseph J Palamar
金额：
$ 69.73万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734617
关键词：
Adult Adverse drug effect Adverse effects Attention Case Study Cessation of life Cocaine Dancing Diffuse Drug Exposure Drug usage Electronic Mail Electronics Enrollment Epidemiology Event Exposure to Fentanyl Festival Future General Population Hair Harm Reduction Heroin Hospitalization Hospitals Ketamine Methamphetamine Methods Mollies Music New York City Opioid Outcome Overdose Participant Patient Self-Report Persons Pharmaceutical Preparations Poisoning Population Prevalence Prevention Probability Samples Reporting Research Personnel Risk Factors Saliva Sampling Schedule Scientist Secure Seizures Social Network Specimen Surveys Testing Theoretical model Toxicology Work adverse outcome bath salts cocaine exposure cocaine use drug testing ecstasy epidemiology study fentanyl analog fentanyl exposure follow-up heroin use high risk high risk population impression innovation novel therapeutics predictive test prevent recruit saliva sample salivary assay synthetic cannabinoid time use trend willingness

项目摘要

New psychoactive substances (NPS) such as fentanyl analogs, synthetic cannabinoids, and synthetic cathinones (“bath salts”) continue to emerge at an alarming rate. We know very little about prevalence of exposure or about effects of these drugs as they emerge—largely because most people exposed are unaware that they used (as these are common adulterants added to drugs like ecstasy and heroin). More advanced toxicology methods are needed to detect exposures and most toxicology studies rely on biospecimens from those who have been hospitalized. Epidemiological survey framework including toxicology methods can help overcome the biases of relying on poisonings and quickly provide information on exposure and effects to those recently exposed, and to scientists and the public. As such, we propose this R01 which examines trends in reported drug use among a high-risk population—electronic dance music (EDM) party attendees. People who attend EDM events (at nightclubs and festivals) are at high risk for use of drugs—particularly NPS, cocaine, ecstasy (MDMA, Molly), LSD, methamphetamine, and opioids—and related adverse outcomes, including death. Given that this high-risk scene may serve as a bellwether for trends that diffuse to the general population, results will help prevent use, overdose, and death not only among EDM partygoers, but also in the general population. Through projects conducted by this team of investigators conducted between 2016 and 2021, we have identified dramatic increases in drug use and unintentional exposure to NPS. In this R01, we will continue to utilize our current R01’s recruitment methods and validated rapid drug survey (which queries use of >100 drugs) to estimate trends in drug use, but we will focus more on our new and innovative toxicological methods. Our toxicology methods will now use saliva testing to test for exposure to >1,000 drugs (including over 120 fentanyl analogs). All participants will be asked their willingness to provide a saliva sample and to take a follow-up survey to assess potential drug-related adverse effects during their night out. We will recruit 4,160 adults entering EDM parties continuously over four years using time-space sampling. This study will allow us to determine who was recently exposed to NPS (which most other labs cannot yet detect) and determine whether factors such as honesty and attention on the survey predict testing positive after not reporting use (based on our modified Impression Management theoretical model). We have confirmed the feasibility of our methods and propose four aims. First, we will estimate the extent to which saliva testing adds to prevalence of reported drug use. Second, we will determine effect profiles of exposure to new NPS as they emerge. Third, we will determine if events such as DEA scheduling of NPS predict changes in trends of NPS exposure. Fourth, we will determine if shifts in use and adverse effects are a bellwether for drug-related outcomes. We will rapidly disseminate our findings regarding NPS exposure and NPS effects in this high-risk population to prevent use and associated harms among EDM partygoers as well as the general public.

新的精神活性物质（NP），例如芬太尼类似物，合成大麻素和合成 Cathinones（“浴沙拉”）继续以惊人的速度出现。我们对流行率一无所知这些药物出现时的暴露或对这些药物的影响 - 很大程度上是因为大多数暴露的人都不知道他们使用的（因为这些是常见的通奸者，例如摇头丸和海洛因等药物）。更高级需要毒理学方法来检测暴露，大多数毒理学研究依赖于来自那些住院的人。包括毒理学方法在内的流行病学调查框架可以帮助克服依赖中毒的偏见，并迅速向那些人提供有关暴露和影响的信息最近暴露于科学家和公众。因此，我们提出了这款R01，该R01考试趋势据报道，高风险人群中的吸毒 - 电子舞蹈音乐（EDM）派对与会者。谁参加EDM活动（在夜总会和节日）有使用药物的高风险 - 尤其是NPS，可卡因，摇头丸（MDMA，Molly），LSD，甲基苯丙胺和阿片类药物，以及相关的不良结果，包括死亡。鉴于这个高风险的场景可以作为趋势的领头羊，以扩散到一般人口，结果将有助于防止使用EDM派对者的使用，服药过量和死亡，而且在一般人口。通过该团队在2016年至之间进行的调查人员进行的项目 2021年，我们已经确定了药物使用和无意间暴露于NP的急剧增加。在这个R01中，我们将继续利用我们当前R01的招聘方法并验证快速药物调查（疑问使用> 100种药物）来估计吸毒的趋势，但我们将更多地专注于我们的新创新性毒理学方法。我们的毒理学方法现在将使用唾液测试来测试接触> 1,000种药物（包括超过120个芬太尼类似物）。所有参与者都将被要求他们提供唾液样本的意愿并进行后续调查，以评估夜晚的潜在药物相关不良影响。我们将使用时间空间抽样招募4,160名成年人在四年内连续进入EDM派对。这项研究将允许我们确定谁最近接触过NP（大多数其他实验室尚未检测到）和确定诸如诚实和注意力之类的因素是否预测测试呈阳性报告使用（基于我们修改的印象管理理论模型）。我们已经确认我们的方法和建议的可行性四个目标。首先，我们将估算唾液测试添加的程度预期使用毒品的患病率。其次，我们将确定接触新NP的效果概况出现。第三，我们将确定诸如NPS的DEA调度等事件是否预测NP趋势的变化接触。第四，我们将确定使用中的偏移和不良影响是与药物有关的领头羊结果。我们将迅速传播有关此高风险中NPS暴露和NPS效应的发现人口可以防止EDM聚会者和公众之间使用和相关危害。