Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods

检查压力对大量社交饮酒者的酒精情绪强化特性的影响：结合实验室和流动方法的多模式调查

基本信息

批准号：
10735704
负责人：
Catharine Fairbairn
金额：
$ 52.32万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-05-31
项目状态：
未结题

项目摘要

Alcohol’s ability to improve mood in the face of stress is among its most prized reinforcing properties, long held by researchers to be of critical importance for the understanding of the etiology of alcohol use disorder (AUD). Drinkers overwhelmingly report that the mood-enhancement they gain from alcohol is most pronounced in the context of stress, and individuals who report higher levels of stress relief from alcohol are at risk for developing AUD. But attempts to capture this key element of alcohol reinforcement using experimental methods have yielded strikingly inconsistent results. One remarkable feature of the extant experimental literature is that, in attempting to capture alcohol’s stress-relieving effects, researchers have strayed far outside the range of stressors typically encountered in everyday drinking settings, contexts that are overwhelmingly social in nature. Here, we harness the power of stressful stimuli that emerge naturally within everyday contexts, focusing on social novelty as a compound stress-trigger ubiquitous to real-world heavy drinking settings. Building on our prior work indicating enhanced alcohol reward in novel compared with familiar social context, together with pilot findings pointing to potential links between social novelty and hazardous patterns of drinking, we draw on innovative methods and measures to further build the understanding of social-contextual factors driving consumption. Specifically, we leverage multi-participant neuroimaging recording arrays (i.e., hyperscanning) to pinpoint both inter- and intra-brain processes underlying alcohol reinforcement, a mechanistic analysis we complement with ambulatory and longitudinal methods for tracing real world patterns of consumption. Participants (N=240) will attend two experimental laboratory sessions, on one of which they will consume alcohol and on the other a control beverage. Participants will complete tasks in the company of either a stranger or familiar individual while EEG is recorded from both participants simultaneously. Participants will also engage in a 14-day ambulatory assessment period during which drinking will be assessed continuously via transdermal alcohol biosensor while social context is explored via in-vivo photographic image- capture methods. Finally, longitudinal changes in hazardous drinking and AUD symptoms will be assessed for 24 months post-baseline. The aims of the project are to: 1) Explore diminished threat sensitivity and enhanced social engagement as mechanisms driving alcohol reward in novel social context; 2) Examine social reward- attentive processes as well as social-contextual novelty as predictors of hazardous drinking and AUD. The proposed research contributes to the understanding of AUD by addressing one of the most fundamental questions in the alcohol literature—the question of why people drink. Further, representing a critical step towards building a contextually-informed, mechanistically precise model of AUD etiology, the proposed study might have a variety of key implications including for refining harm-reduction and prevention programs, reducing rates of relapse, informing public health policy, and the early identification of those at risk.

酒精面对压力的能力是其最珍贵的加强特性之一，长期保持研究人员对于理解酒精使用障碍的病因（AUD）至关重要。饮酒者压倒性地报告说，他们从酒精中获得的情绪增强最为明显压力的背景以及报告较高水平从酒精中缓解压力的个人有可能发展的风险奥德但是尝试使用实验方法捕获酒精加强的关键要素产生了惊人的不一致的结果。现存的实验文献的一个显着特征是，试图捕获酒精的压力舒适效果，研究人员偏离了远方的范围每天饮酒环境中通常会遇到的幅度，这些环境绝大多数是社交的自然。在这里，我们利用在日常情况下自然出现的压力刺激的力量，专注于社会新颖性，作为对现实世界中重型饮酒环境无处不在的复合压力触发。与熟悉的社会背景相比加上飞行员发现，指出了社会新颖性与危险模式之间的潜在联系喝酒，我们利用创新的方法和措施，以进一步建立对社会上下文的理解推动消费的因素。具体而言，我们利用多参与者的神经影像记录阵列（即高级扫描），以查明酒精加固的基础间和脑内过程，A 机械分析我们采用卧床和纵向方法来追踪现实世界的模式消费。参与者（n = 240）将参加两个实验实验室会议，其中之一将食用酒精，另一个将在控制卧室上。参与者将完成公司的任务在两个参与者记录脑电图时，陌生人或熟悉的人。参与者还将参加为期14天的门诊评估期，在此期间将进行饮酒。通过透皮醇生物传感器连续探索社会环境，通过体内摄影图像 - 捕获方法。最后，将评估危险饮酒和AUD症状的纵向变化基线后24个月。该项目的目的是：1）探索威胁敏感性降低并增强社会参与作为在新颖的社会背景下推动酒精奖励的机制； 2）检查社会奖励 - 细心的过程以及社会上下文的新颖性，作为危险饮酒和aud的预测指标。拟议的研究通过解决最基本的一种，有助于理解AUD 酒精文学中的问题 - 人们为什么喝酒的问题。此外，代表关键步骤为了建立一个拟议的研究，构建一个具有上下文信息的机械性，机械精确的模型可能具有多种关键含义，包括用于减少危害和预防计划，降低退休率，告知公共卫生政策以及对处于危险的人的早期识别。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Using machine learning for real-time BAC estimation from a new-generation transdermal biosensor in the laboratory.

DOI：
10.1016/j.drugalcdep.2020.108205
发表时间：
2020-11-01
期刊：
Drug and alcohol dependence
影响因子：
4.2
作者：
Fairbairn CE;Kang D;Bosch N
通讯作者：
Bosch N

Mixing Misery and Gin: The Effect of Alcohol Administration on Ostracism Response.

DOI：
10.1177/01461672211038450
发表时间：
2022-08
期刊：
Personality & social psychology bulletin
影响因子：
4
作者：
Fairbairn CE;Creswell KG;Hales AH;Williams KD;Wilkins KV
通讯作者：
Wilkins KV

A new generation of transdermal alcohol biosensing technology: practical applications, machine -learning analytics and questions for future research.

DOI：
10.1111/add.15523
发表时间：
2021-10
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Fairbairn CE;Bosch N
通讯作者：
Bosch N

Examining new-generation transdermal alcohol biosensor performance across laboratory and field contexts.

在实验室和现场环境中检查新一代透皮酒精生物传感器的性能。

DOI：
10.1111/acer.14977
发表时间：
2023
期刊：
Alcohol, clinical & experimental research
影响因子：
0
作者：
Ariss,Talia;Fairbairn,CatharineE;Bosch,Nigel
通讯作者：
Bosch,Nigel

Alcohol narrows physical distance between strangers.

DOI：
10.1073/pnas.2101937118
发表时间：
2021-05-18
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Gurrieri L;Fairbairn CE;Sayette MA;Bosch N
通讯作者：
Bosch N