Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods

检查压力对大量社交饮酒者的酒精情绪强化特性的影响：结合实验室和流动方法的多模式调查

基本信息

批准号：
10735704
负责人：
Catharine Fairbairn
金额：
$ 52.32万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-05-31
项目状态：
未结题

项目摘要

Alcohol’s ability to improve mood in the face of stress is among its most prized reinforcing properties, long held by researchers to be of critical importance for the understanding of the etiology of alcohol use disorder (AUD). Drinkers overwhelmingly report that the mood-enhancement they gain from alcohol is most pronounced in the context of stress, and individuals who report higher levels of stress relief from alcohol are at risk for developing AUD. But attempts to capture this key element of alcohol reinforcement using experimental methods have yielded strikingly inconsistent results. One remarkable feature of the extant experimental literature is that, in attempting to capture alcohol’s stress-relieving effects, researchers have strayed far outside the range of stressors typically encountered in everyday drinking settings, contexts that are overwhelmingly social in nature. Here, we harness the power of stressful stimuli that emerge naturally within everyday contexts, focusing on social novelty as a compound stress-trigger ubiquitous to real-world heavy drinking settings. Building on our prior work indicating enhanced alcohol reward in novel compared with familiar social context, together with pilot findings pointing to potential links between social novelty and hazardous patterns of drinking, we draw on innovative methods and measures to further build the understanding of social-contextual factors driving consumption. Specifically, we leverage multi-participant neuroimaging recording arrays (i.e., hyperscanning) to pinpoint both inter- and intra-brain processes underlying alcohol reinforcement, a mechanistic analysis we complement with ambulatory and longitudinal methods for tracing real world patterns of consumption. Participants (N=240) will attend two experimental laboratory sessions, on one of which they will consume alcohol and on the other a control beverage. Participants will complete tasks in the company of either a stranger or familiar individual while EEG is recorded from both participants simultaneously. Participants will also engage in a 14-day ambulatory assessment period during which drinking will be assessed continuously via transdermal alcohol biosensor while social context is explored via in-vivo photographic image- capture methods. Finally, longitudinal changes in hazardous drinking and AUD symptoms will be assessed for 24 months post-baseline. The aims of the project are to: 1) Explore diminished threat sensitivity and enhanced social engagement as mechanisms driving alcohol reward in novel social context; 2) Examine social reward- attentive processes as well as social-contextual novelty as predictors of hazardous drinking and AUD. The proposed research contributes to the understanding of AUD by addressing one of the most fundamental questions in the alcohol literature—the question of why people drink. Further, representing a critical step towards building a contextually-informed, mechanistically precise model of AUD etiology, the proposed study might have a variety of key implications including for refining harm-reduction and prevention programs, reducing rates of relapse, informing public health policy, and the early identification of those at risk.

酒精在面对压力时改善情绪的能力是其最珍贵的强化特性之一，长期以来一直被认为研究人员认为这对于理解酒精使用障碍（AUD）的病因学至关重要。绝大多数饮酒者表示，酒精对他们情绪的改善在以下方面最为明显：压力环境下，那些报告通过酒精缓解压力水平较高的人有患上这种疾病的风险 AUD。但尝试使用实验方法捕获酒精强化的这一关键要素。现有实验文献的一个显着特征是，在为了捕捉酒精缓解压力的作用，研究人员已经远远超出了酒精的范围。通常在日常饮酒环境中遇到的压力源，以及绝大多数社交环境中的压力源在这里，我们利用日常环境中自然出现的压力刺激的力量，关注社交新奇作为现实世界酗酒环境中普遍存在的复合压力触发因素。基于我们之前的研究表明，与熟悉的社会背景相比，小说中的酒精奖励有所增加，连同试点结果指出社会新颖性和危险模式之间的潜在联系饮酒，我们利用创新的方法和措施来进一步建立对社会背景的理解具体来说，我们利用多参与者神经影像记录阵列（即，超扫描）来查明酒精强化背后的脑间和脑内过程，我们用动态和纵向方法来补充机械分析，以追踪现实世界的模式参与者（N = 240）将参加两场实验实验室会议，其中一场是他们参加的。参与者将饮酒，而另一方则在控制饮料的陪伴下完成任务。无论是陌生人还是熟悉的人，同时记录两个参与者的脑电图。参与者还将接受为期 14 天的流动评估期，在此期间将评估饮酒情况通过透皮酒精生物传感器不断地进行研究，同时通过体内摄影图像探索社会背景- 最后，将评估危险饮酒和 AUD 症状的纵向变化。基线后 24 个月，该项目的目标是： 1) 探索威胁敏感性的降低和增强。社会参与作为新社会环境中酒精驱动奖励的机制；2）检查社会奖励- 注意力过程以及社会背景的新颖性作为危险饮酒和澳元的预测因素。拟议的研究通过解决最基本的问题之一，有助于理解 AUD 酒精文献中的问题——人们为什么喝酒的问题，代表着关键的一步。为拟议的研究建立一个上下文信息丰富、机械精确的 AUD 病因模型可能会产生各种关键影响，包括完善减少伤害和预防计划，降低复发率，为公共卫生政策提供信息，并及早识别高危人群。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Using machine learning for real-time BAC estimation from a new-generation transdermal biosensor in the laboratory.

DOI：
10.1016/j.drugalcdep.2020.108205
发表时间：
2020-11-01
期刊：
Drug and alcohol dependence
影响因子：
4.2
作者：
Fairbairn CE;Kang D;Bosch N
通讯作者：
Bosch N

Mixing Misery and Gin: The Effect of Alcohol Administration on Ostracism Response.

DOI：
10.1177/01461672211038450
发表时间：
2022-08
期刊：
Personality & social psychology bulletin
影响因子：
4
作者：
Fairbairn CE;Creswell KG;Hales AH;Williams KD;Wilkins KV
通讯作者：
Wilkins KV

A new generation of transdermal alcohol biosensing technology: practical applications, machine -learning analytics and questions for future research.

DOI：
10.1111/add.15523
发表时间：
2021-10
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Fairbairn CE;Bosch N
通讯作者：
Bosch N

Examining new-generation transdermal alcohol biosensor performance across laboratory and field contexts.

在实验室和现场环境中检查新一代透皮酒精生物传感器的性能。

DOI：
10.1111/acer.14977
发表时间：
2023
期刊：
Alcohol, clinical & experimental research
影响因子：
0
作者：
Ariss,Talia;Fairbairn,CatharineE;Bosch,Nigel
通讯作者：
Bosch,Nigel

Alcohol narrows physical distance between strangers.

DOI：
10.1073/pnas.2101937118
发表时间：
2021-05-18
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Gurrieri L;Fairbairn CE;Sayette MA;Bosch N
通讯作者：
Bosch N