Nervous System Development and Injury

神经系统发育和损伤

• 批准号: 9386458
• 负责人: DAVID M. HOLTZMAN
• 金额: $ 0.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9386458
• 关键词: Injury; nervous system development

DESCRIPTION (provided by applicant): The present application seeks continued funding for a training program at Washington University Medical School that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 29 years. The theme of the research carried out by the trainees and faculty of this grant is translational research in nervous system injury and degeneration. The primary applicant pool for the four slots requested are MD or MD/PhD residents in adult neurology, pediatric neurology, and neurosurgery at this institution. A limited number of Ph.D. candidates carrying out research consistent with the theme in the laboratories of the faculty members will also be considered, as will residents from other neuroscience-related clinical departments or residents from other institutions that seek training with our faculty. The faculty of 45 is composed of well-funded members of several clinical and basic science departments, most of whom have extensive experience in training young scientists and physician scientists. It is expected that trainees supported by this grant will carr out laboratory-based and/or clinically-based translational research for a minimum of two years as this is the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinician scientists needed to advance our understanding of the pathogenesis and treatment of these neurological disorders. In addition to the mentored research projects, trainees will participate, depending upon interests and experience, in individually designed didactic (courses, workshops, journal clubs) programs to develop needed background, specialized technical skills, and communication skills in preparation for an independent research career. All trainees will also receive training in the ethical conduct of research appropriate for whether they are primary focused on clinical vs. laboratory-based research. Procedures are described to select, evaluate, and counsel trainees. We have enjoyed reasonable success in identifying excellent minority participants in the program and efforts to further strengthen this aspect of our program are described. This program has, and will continue to, build upon the long tradition of excellent basic and clinical neuroscience at Washington University toward the objective of training the next generation of clinician scientists dedicated to understanding and treating disorders of the nervous system.

描述（由申请人提供）：本申请寻求持续资助华盛顿大学医学院的培训项目，该项目在过去 29 年中一直由神经病学系和神经外科系联合管理。本次资助的学员和教师进行的研究主题是神经系统的转化研究 系统损伤和退化。所请求的四个名额的主要申请人群体是该机构成人神经病学、儿科神经病学和神经外科领域的医学博士或医学博士/博士住院医师。博士学位数量有限。在教师实验室进行与主题一致的研究的候选人也将被考虑，来自其他神经科学相关临床部门的住院医师或来自其他机构寻求与我们教师一起培训的住院医师也将被考虑。 45名教职员工由来自多个临床和基础科学系的资金雄厚的成员组成，其中大多数人在培养年轻科学家和医师科学家方面拥有丰富的经验。预计这笔赠款支持的学员将进行至少两年的基于实验室和/或临床的转化研究，因为这是培养经过科学培训的神经学或神经外科临床医生科学家所需的最短时间。我们对这些神经系统疾病的发病机制和治疗的了解。除了指导的研究项目外，学员还将根据兴趣和经验参加单独设计的教学（课程、研讨会、期刊俱乐部）计划，以培养所需的背景、专业技术技能和沟通技巧，为独立研究生涯做好准备。所有学员还将接受研究道德行为方面的培训，无论他们主要关注的是临床研究还是实验室研究。描述了选择、评估和咨询受训者的程序。我们在确定该计划中优秀的少数族裔参与者方面取得了相当的成功，并描述了进一步加强我们计划这方面的努力。该项目已经并将继续建立在华盛顿大学优秀的基础和临床神经科学的悠久传统之上，旨在培养致力于理解和治疗神经系统疾病的下一代临床科学家。

项目成果

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.

结节性硬化症中室管膜下巨细胞星形细胞瘤的发育起源。

• 发表时间: 2005-04-26
• 作者: Ess, Kevin C;Kamp, Christine A;Tu, Benjamin P;Gutmann, David H
• 通讯作者: Gutmann, David H

Symptomatic thoracic spinal cord herniation: case series and technical report.

有症状的胸脊髓疝：病例系列和技术报告。

• 发表时间: 2014-09
• 影响因子: 4.8
• 作者: Hawasli, Ammar H;Ray, Wilson Z;Wright, Neill M
• 通讯作者: Wright, Neill M

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury.

神经生长因子在成人背根神经节神经元中的作用及其对损伤的反应。

• 发表时间: 1984-11-20
• 作者: Rich, K M;Yip, H K;Osborne, P A;Schmidt, R E;Johnson Jr, E M
• 通讯作者: Johnson Jr, E M

Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging.

阿尔茨海默型老年痴呆症和正常衰老中的脑室周围白质透明。

• 发表时间: 1987-08
• 影响因子: 9.9
• 作者: Rezek, D L;Morris, J C;Fulling, K H;Gado, M H
• 通讯作者: Gado, M H

Borden-Shucart Type I dural arteriovenous fistulas: clinical course including risk of conversion to higher-grade fistulas.

Borden-Shucart I 型硬脑膜动静脉瘘：临床过程，包括转化为高级瘘的风险。

• 发表时间: 2012-09
• 影响因子: 4.1
• 作者: Shah, Manish N;Botros, James A;Pilgram, Thomas K;Moran, Christopher J;Cross 3rd, Dewitte T;Chicoine, Michael R;Rich, Keith M;Dacey Jr, Ralph G;Derdeyn, Colin P;Zipfel, Gregory J
• 通讯作者: Zipfel, Gregory J