Adolescent Working Memory and White Matter Development

青少年工作记忆和白质发育

• 批准号: 7290387
• 负责人: Bonnie J Nagel
• 金额: $ 12.12万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7290387
• 关键词: Accounting; Adolescence; Adolescent; Age; Anisotropy; Area; Assimilations; Behavioral; Brain; Child; Childhood; Cognition; Cognitive; Condition; Cross-Sectional Studies; Data; Data Collection; Development; Diffusion Magnetic Resonance Imaging; Dissociation; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Imaging Techniques; K-Series Research Career Programs; Left; Longitudinal Studies; Measures; Mediating; Mentors; Methods; Modality; Neurobiology; Neurologic; Neuropsychological Tests; Numbers; Pattern; Performance; Population; Research; Research Design; Research Personnel; Research Training; Sampling; Short-Term Memory; Structure; Techniques; Technology; Training; age related; analog; career; cognitive function; frontal lobe; improved; indexing; neurodevelopment; neuroimaging; neuropsychological; novel; relating to nervous system; response; skills; white matter

DESCRIPTION (provided by applicant): Studies utilizing modern neuroimaging techniques have provided clear evidence that the adolescent brain is actively developing. This neurodevelopment, particularly in the frontal lobes, coincides with improvements in several areas of higher order cognitive functioning, including working memory abilities. It has been documented that working memory skills are crucial to the intact performance in several other cognitive domains. Deficits in working memory have been demonstrated among a number of neurological and psychiatric conditions that manifest during adolescence. However, the neurobiological substrates of working memory in even normally developing adolescents remain unclear. The current cross-sectional study proposes to integrate neuropsychological, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) techniques to more clearly explore frontal lobe white matter development as it relates to both verbal and spatial working memory functioning in 90 typically developing adolescents (ages 12 to 17). It is hypothesized that 1) working memory abilities will be positively associated with age, 2) adolescents will show a hemispheric dissociation between the verbal and spatial working memory tasks that will become more pronounced with increasing age, 3) prefrontal white matter integrity will show a significant positive correlation with age and will mediate the positive relationship between age and working memory performance, and 4) prefrontal white matter integrity will be positively associated with nearby cortical fMRI response during the working memory tasks. The applicant is requesting a five-year mentored Career Development Award (K08) in order to develop the skills and expertise necessary for answering these research questions. Career development activities will include training in DTI data collection and analysis, development of expertise in fMRI, training in developmentally-focused longitudinal study design and analytical techniques and continued training in the ethical conduct of scientific research with children and adolescents. The proposed training plan will include structured coursework, seminars, and mentoring by experts in the fields of development and neuroimaging. Together, the implementation of this training and research plan will provide the beginnings of a much-needed framework for understanding the neurobiological substrates of working memory during adolescence and will allow the applicant to transition into an independent investigator specializing in longitudinal examination of adolescent cognition and neurodevelopment.

描述（由申请人提供）：利用现代神经影像学技术的研究提供了明确的证据，表明青少年大脑正在积极发展。这种神经发育，尤其是在额叶叶中，与高阶认知功能（包括工作记忆能力）的几个领域的改进相吻合。已经有记录，工作记忆技能对于其他几个认知领域的完整表现至关重要。在青春期表现出的许多神经和精神病疾病中，工作记忆的缺陷已被证明。但是，即使是正常发展的青少年，工作记忆的神经生物学底物仍不清楚。当前的横截面研究提出，将神经心理学，功能磁共振成像（FMRI）和扩散张量成像（DTI）技术整合到更清楚地探索额叶白质的发展，因为它与90个通常发展的undeventents的言语和空间工作记忆相关，通常是言语和空间工作记忆，通常在90个典型发展的u（ages 12至17）。 It is hypothesized that 1) working memory abilities will be positively associated with age, 2) adolescents will show a hemispheric dissociation between the verbal and spatial working memory tasks that will become more pronounced with increasing age, 3) prefrontal white matter integrity will show a significant positive correlation with age and will mediate the positive relationship between age and working memory performance, and 4) prefrontal white matter integrity will be positively associated with nearby工作记忆任务期间的皮质fMRI响应。申请人要求五年指导的职业发展奖（K08），以发展回答这些研究问题所需的技能和专业知识。职业发展活动将包括在DTI数据收集和分析中进行培训，fMRI专业知识的发展，以发展为中心的纵向研究设计和分析技术的培训，以及对与儿童和青少年进行科学研究的道德规范培训。拟议的培训计划将包括结构化课程，研讨会以及发展和神经影像领域的专家的指导。共同的实施该培训和研究计划将提供一个急需的框架的开始，以了解青春期工作记忆的神经生物学基质，并使申请人可以过渡到专门研究青少年认知和神经转化的纵向研究的独立研究者。