Structural and Functional neural correlates of early postnatal deprivation

产后早期剥夺的结构和功能神经相关性

基本信息

批准号：
7317278
负责人：
MICHAEL E BEHEN
金额：
$ 13.86万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-03 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7317278
关键词：
Age Anisotropy Applications Grants Autistic Disorder Behavioral Brain Brain region Characteristics Child Chronic stress Clinical Collaborations Complex Data Data Analyses Depth Diffusion Magnetic Resonance Imaging Emotional Functional Imaging Functional disorder Gender Goals Hand Handedness Image Imaging Device Imaging Techniques Investigation Language Lateral Learning Link Magnetic Resonance Imaging Measures Medial Memory Mentors Methods Michigan Monitor Neurobiology Neurocognitive Neurologic Neurosciences Orphanages Pathway interactions Pediatric Hospitals Phase Phenotype Positron-Emission Tomography Principal Investigator Protocols documentation Psychologist Recording of previous events Reporting Research Research Personnel Sampling Serotonin Techniques Thalamic structure Therapeutic Intervention Thinking Training Training Programs Tryptophan Work brain behavior brain volume career deprivation design early experience executive function experience frontal lobe gray matter innovation neuroimaging neuropsychological postnatal relating to nervous system social deprivation tool uptake white matter

项目摘要

DESCRIPTION (provided by applicant): Despite links between early postnatal deprivation (ESD) and neuropsychological problems, few studies have investigated whether the neural substrates thought to subserve such functions are abnormal in children with such histories. The small body of work that has investigated neurologic consequences in ESD has reported both functional and structural brain abnormalities (Eluvathingal et al., 2006). The overarching aim of the proposed studies is to probe, with imaging techniques, the structural and functional neurobiological consequences of ESD. We will utilize volumetric MRI, diffusion tensor imaging (DTI), and a-[11 C]methyl-L- tryptophan (AMT) PET to evaluate the structural and functional integrity of cortical and subcortical brain regions and white matter pathways and link findings to the neuropsychological functions reported to be impaired in children with histories of ESD. The principal investigator (PI), a clinical psychologist with experience in designing and conducting research in defining neuropsychological phenotypes in investigations of brain-behavior relationships, will conduct all phases of the project as part of a training program that includes didactic training in neurosciences and PET and MRI imaging, and relationships with five internationally renowned mentors, all with substantial expertise in the conduct of research investigating brain-behavior relationships utilizing structural and functional imaging tools. The major thrust of the training protocols involve providing the PI with tools necessary to obtain a deeper conceptual understanding of the mechanisms that underlie imaging techniques as research tools for studying brain-behavior relationships, and in utilizing imaging protocols/data in neuroscientific research. The proposed studies are among the first to evaluate the neuroanatomical correlates of ESD in human children. Our approach of integrating MRI and PET methods with neuropsychological assessments is innovative and will yield new and important data on children exposed to ESD. Neuroimaging data can be used to monitor effects of therapeutic interventions and to assess the potential reversibility of findings, which has not been possible in the past. Thus, these studies have potential translational value. From the perspective of the applicant, the proposed studies are an important component of the outlined career goal in that the applicant will learn both MRI and PET imaging techniques from an established mentor and co-mentors and will develop into an independent investigator.

描述（由申请人提供）：尽管早期出生后剥夺（ESD）与神经心理问题之间有联系，但很少有研究研究了具有这种病史的儿童的神经基质是否异常。研究了ESD中神经系统后果的小型工作已经报道了功能和结构性脑异常（Eluvathingal等，2006）。拟议的研究的总体目的是用成像技术，结构和功能性神经生物学后果进行探测。我们将利用体积MRI，扩散张量成像（DTI）和A- [11 C]甲基-l-色氨酸（AMT）PET来评估皮质和皮层脑区域的结构和功能完整性，以及皮层和皮层脑区域的结构和功能完整性，白质途径，并将发现与据报道的神经心理功能与具有历史悠久的儿童相关。首席研究者（PI）是一名临床心理学家，具有设计和进行研究方面的经验，以定义神经心理学表型在研究脑 - 行为关系的调查中，将进行项目的所有阶段，作为培训计划的一部分，作为培训计划的一部分，包括在神经镜上进行教学的培训，包括神经镜的培训，宠物和MRI成像，以及与五个国际化的脑部研究人员的关系，以及在各种脑海中的关系，在各种方面的研究，各种各样的人际关系，各种各样的既定性专业，各种各样的既定性，则在各种方面均具有跨性别的培训。结构和功能成像工具。培训方案的主要目的涉及为PI提供所需的工具，以更深入地了解成像技术作为研究脑行为关系的研究工具，并利用神经科学研究中的成像协议/数据。拟议的研究是最早评估人类儿童ESD神经解剖学相关性的研究。我们将MRI和PET方法与神经心理学评估相结合的方法是创新的，并且将为暴露于ESD的儿童提供新的重要数据。神经影像数据可用于监测治疗性干预措施的影响，并评估发现的潜在可逆性，这过去是不可能的。因此，这些研究具有潜在的翻译价值。从申请人的角度来看，拟议的研究是概述的职业目标的重要组成部分，因为申请人将从既定的导师和联合学者中同时学习MRI和PET成像技术，并将发展成为独立的研究人员。