Mentoring in Patient-Oriented Neuroscience Research

以患者为导向的神经科学研究的指导

基本信息

批准号：
9370423
负责人：
MARISA M SILVERI
金额：
$ 15.13万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-08 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9370423
关键词：
Abstinence Adolescent Alcohol abuse Alcohol consumption Anxiety Applications Grants Area Award Child Abuse and Neglect Clinical Clinical Research Collaborations Comorbidity Data Set Development Development Plans Doctor of Philosophy Environment Epigenetic Process Faculty Foundations Funding Future Goals Grant Hospitals Intervention Laboratories Mental Health Mental disorders Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Monitor National Center for Complementary and Alternative Medicine National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neurobiology Neurosciences Research Patients Prevention Principal Investigator Psychiatry Psychopathology Public Health Publications Research Research Personnel Risk Time Training Trust United States National Institutes of Health Work addiction adolescent brain development adolescent patient alcohol use disorder binge drinker career career development dual diagnosis effective therapy emerging adult interest lectures medical schools mid-career faculty next generation outreach patient oriented patient oriented research patient population programs secondary analysis skills

项目摘要

PROJECT SUMMARY I am a clinical researcher and Director of the Neurodevelopmental Laboratory on Addictions and Mental Health at McLean Hospital. I also am an Associate Professor in Psychiatry at Harvard Medical School. I have been continuously funded as a principal investigator (PI) to conduct NIAAA-sponsored patient-oriented research (POR) since 2004 and have been a collaborator and consultant on several additional NIH-sponsored grants. My research has focused on understanding adolescent brain development, and risk for and underlying neurobiology of addiction and psychiatric disorders. I currently serve as PI on one NIAAA R01 grant and one Foundation grant, and am Co-Investigator on 3 R01s (NIMH, NCCAM, NIDA) and 1 R21 (NIAAA). I mentor a growing group of junior investigators, including 3 mentees on K01 grants. I work in a rich environment for clinical research, which is ideal for training junior faculty in POR. However, I receive no institutional support for mentoring and will be required to curtail mentoring efforts to assume significant non-research responsibilities beginning in 2017. The K24 award will protect time that would permit an increase in intensive mentorship to junior investigators and attract researchers to POR. My immediate and long-term career objectives are to characterize neurobiological markers in addiction and psychiatric disorders, which will inform the development of new and effective treatments for alcohol use disorders and for patients with dual diagnoses, and to train the next generation of investigators to develop the skills they require to effectively conduct POR. I also remain committed to disseminating research findings (through publications, scientific lectures and public outreach) that will help prevention efforts and that will inform treatment interventions, to aid in the reduction of suffering due to alcohol use and abuse. The specific aims to be accomplished during the period of the award are to 1) provide substantive mentoring of junior investigators in POR (35%), 2) continue and extend involvement in my POR (10%), and 3) develop specific new content expertise in the areas of adolescent comorbid psychopathology, clinical approaches in adolescent treatment settings, and epigenetics (5%). I am committed to training a remarkable group of mentees, who are the future of addiction and psychiatry POR. Through intensive mentoring I will, in turn, enhance my POR by increasing my clinical perspectives, and by incorporating treatment and epigenetic components into new POR initiatives.

项目概要我是成瘾和心理健康神经发育实验室的临床研究员和主任在麦克莱恩医院。我也是哈佛医学院精神病学副教授。我曾经作为首席研究员 (PI) 持续资助进行 NIAAA 资助的以患者为导向的研究自 2004 年起担任 POR（POR），并一直是 NIH 资助的多项额外资助的合作者和顾问。我的研究重点是了解青少年大脑发育以及潜在的风险成瘾和精神疾病的神经生物学。我目前担任一项 NIAAA R01 资助项目的 PI 和一项基金会拨款，是 3 R01（NIMH、NCCAM、NIDA）和 1 R21（NIAAA）的联合研究员。我指导一个初级研究人员队伍不断壮大，其中包括 3 名获得 K01 资助的学员。我在一个富裕的环境中工作临床研究，是培训 POR 初级教师的理想选择。然而，我没有得到任何机构支持指导，并将被要求减少指导工作以承担重要的非研究职责从 2017 年开始。K24 奖项将保护时间，以便加强强化指导初级研究人员并吸引研究人员参与 POR。我的近期和长期职业目标是描述成瘾和精神疾病的神经生物学标志物，这将为发展提供信息为酒精使用障碍和双重诊断患者提供新的有效治疗方法，并培训下一代调查人员培养有效开展 POR 所需的技能。我也留下来致力于传播研究成果（通过出版物、科学讲座和公共宣传）将有助于预防工作，并为治疗干预措施提供信息，以帮助减少因饮酒和滥用酒精。奖励期间要实现的具体目标是 1) 提供对 POR 中的初级研究者进行实质性指导 (35%)，2) 继续并扩大对我的 POR 的参与 (10%)，以及 3) 在青少年共病精神病理学领域开发具体的新内容专业知识，青少年治疗环境中的临床方法和表观遗传学（5%）。我致力于培养一个一群杰出的学员，他们是成瘾和精神病学 POR 的未来。通过强化反过来，我将通过增加我的临床视角并结合治疗和表观遗传成分纳入新的 POR 计划中。