Functional genetic variants in substance use disorders

物质使用障碍的功能性遗传变异

基本信息

批准号：
10715201
负责人：
HOWARD J EDENBERG
金额：
$ 25.4万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10715201
关键词：
3&apos Untranslated Regions Administrative Supplement Affect Alleles Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Animal Model Automobile Driving Biological Assay Brain CRISPR screen Candidate Disease Gene Catalogs Cell Line Clinical Trials Code Complex Computer Models Data Dementia Disease Enhancers Funding Gene Expression Gene Expression Regulation Genes Genetic Genetic Diseases Genetic Variation Goals Grant Lead Linkage Disequilibrium Machine Learning Measures Methods Modeling Multiomic Data Neurons Nucleic Acid Regulatory Sequences Pathway interactions Regulatory Element Reporter Risk Role Series Substance Use Disorder Testing United States National Institutes of Health Untranslated RNA Validation Variant cell type design detection assay disorder risk experimental study follow-up functional genomics genetic variant genome wide association study genomic variation high throughput screening insight insurance claims parent grant predictive modeling promoter response single cell technology

3&apos Untranslated Regions Administrative Supplement Affect Alleles Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Animal Model Automobile Driving Biological Assay Brain CRISPR screen Candidate Disease Gene Catalogs Cell Line Clinical Trials Code Complex Computer Models Data Dementia Disease Enhancers Funding Gene Expression Gene Expression Regulation Genes Genetic Genetic Diseases Genetic Variation Goals Grant Lead Linkage Disequilibrium Machine Learning Measures Methods Modeling Multiomic Data Neurons Nucleic Acid Regulatory Sequences Pathway interactions Regulatory Element Reporter Risk Role Series Substance Use Disorder Testing United States National Institutes of Health Untranslated RNA Validation Variant cell type design detection assay disorder risk experimental study follow-up functional genomics genetic variant genome wide association study genomic variation high throughput screening insight insurance claims parent grant predictive modeling promoter response single cell technology

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项目摘要

Project Summary: GWAS assays have (and will continue to) detected loci that influence the risk for Alzheimer’s disease and related dementias, but the loci usually contain hundreds to thousands of variants and GWAS do not identify which variants and genes actually affect the risk. Therefore, functional assays are necessary to identify the SNPs and genes within a locus that actually affect risk, to give insights into the mechanisms underlying the disorders and leads to follow for better treatment. The parent grant uses high-throughput assays to identify, within loci relevant to Substance Use Disorders, the functional SNPs that affect gene expression and the genes and pathways they affect. This supplement will expand the scope of the funded grant to target loci relevant to Alzheimer’s disease and related dementias, and thereby provide important data on disease mechanisms and potential therapies.

项目摘要： GWAS Assas已（并将继续）检测到影响阿尔茨海默氏病风险和相关的痴呆症，但本地通常包含数百至数千个变体，而GWAS不确定哪些变体和基因实际上会影响风险。因此，功能分析是必要的实际影响风险的基因座中的SNP和基因，以深入了解该机制疾病和导致遵循以进行更好的治疗。父母赠款使用高通量测定法来识别，在与物质使用障碍相关的位置中，影响基因表达和的功能性SNP 它们影响的基因和途径。这种补充将扩大资助的赠款范围与阿尔茨海默氏病和相关痴呆症有关，从而提供有关疾病的重要数据机制和潜在疗法。