Core C: Biostatistics

核心 C：生物统计学

基本信息

批准号：
10715767
负责人：
Summer S Han
金额：
$ 13.24万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-20 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10715767
关键词：
Address Administrative Personnel Advanced Development Basic Science Bioinformatics Biological Biometry Biostatistics Core Cells Clinical Clinical Data Clinical Research Clinical Trials Clinical Trials Design Collaborations Communication Communities Computing Methodologies Data Data Analyses Data Collection Data Scientist Data Set Development Elements Ensure Environment Epidemiologist Equity Experimental Designs Formulation Genetic Genomics Genotype Goals Grant Housing Image Infrastructure Institution Intervention Laboratory Study Maintenance Methods Mission Molecular Observational Study Output Pathway interactions Patient Monitoring Phenotype Play Policies Positioning Attribute Procedures Program Research Project Grants Publications Randomized Reporting Research Research Design Research Personnel Research Project Grants Resource Sharing Resources Sample Size Science Secure Services Specialist Statistical Data Interpretation Statistical Methods Structure Supervision Talents Technology Translational Research United States National Institutes of Health Universities biomedical data science biomedical informatics cancer genomics cellular imaging data harmonization data management data repository data standards design experience experimental study follow-up genomic data human data human subject human tissue innovation interdisciplinary approach malignant stomach neoplasm medical schools meetings member mid-career faculty next generation sequencing novel open source pre-clinical prevent risk stratification single cell analysis web-based tool

项目摘要

ABSTRACT – BIOSTATISTICS CORE C The goal of the Biostatistics Core is to provide support for the statistical analysis generated from three projects. These supportive functions include the implementation of the study design and data analysis, the development and applications of innovative statistical methods for single cell genomics and the timely dissemination of findings as related to publications and research meetings. In summary this support consists of the following: (1) Provide expert and timely consultative services to Project investigators throughout the course of research. (2) Organize clinical data generated from the PPG. (3) Develop statistical methods suitable for single cell analysis. (4) Aid in reporting results with the Project teams. The core team consists of biostatisticians, data management specialists, data scientists, epidemiologists, and administrative personnel. The Biostatistics Core team will communicate regularly and in a structured format with project investigators to ensure the appropriate design, analysis and interpretation of preclinical and clinical experiments of the PPG. The Biostatistics Core has experience and expertise across the breadth of biostatistics including within the domains of computational genetic data set analysis, analysis of biological pathways, clinical trial design and analysis, and observational study design and analysis. This support will include the planning of new studies with regards to experimental design, estimation of sample size and power calculations, and methods for randomization when appropriate. The Biostatistics Core will collaborate with the PPG investigators in all stages of research, from the formulation of the research questions through study design, data management, and data analyses for laboratory studies (Projects 1-2), studies involving human tissues, observational and clinical trial studies (Project 3), and principal interpretation for dissemination. The Biostatistics Core will closely coordinate with the Administrative Core A and the Cellular, Genomics and Imaging Core B to ensure timely completion of research objectives, efficient use of shared resources, effective dissemination of research findings, and compliance with regulatory policy and reporting requirements.

摘要 – 生物统计学核心 C 生物统计核心的目标是为三个项目生成的统计分析提供支持。这些支持功能包括研究设计和数据分析的实施、开发单细胞基因组学创新统计方法的应用和及时传播研究结果与出版物和研究会议相关的支持总而言之包括以下内容：（1）在整个项目过程中为项目调查人员提供专业、及时的咨询服务研究。 (2)整理PPG生成的临床数据。 (3)开发适合单细胞分析的统计方法。 (4) 协助向项目团队报告结果。核心团队由生物统计学家、数据管理专家、数据科学家、流行病学家和生物统计核心团队将定期以结构化的方式与管理人员进行沟通。项目研究者确保临床前和临床的适当设计、分析和解释 PPG 的生物统计学核心在生物统计学领域拥有丰富的经验和专业知识。包括计算遗传数据集分析、生物途径分析、临床试验设计和分析，以及观察性研究设计和分析。这种支持将包括规划。关于实验设计、样本量估计和功效计算以及方法的新研究适当时进行随机化。生物统计核心将与 PPG 研究人员合作。研究阶段，从研究问题的制定到研究设计、数据管理和实验室研究（项目 1-2）、涉及人体组织的研究、观察和临床的数据分析试验研究（项目 3）和传播的主要解释将密切相关。与行政核心 A 和细胞、基因组学和成像核心 B 协调，确保及时完成研究目标，有效利用共享资源，有效传播研究成果，遵守监管政策和报告要求。