NCATS LINKAGE HONEST BROKER (LHB) - PATIENT-CENTERED OUTCOMES RESEARCH (PCOR) TRUST FUND ASPE NATIONAL COVID-19 LONGITUDINAL RESEARCH DATABASE LINKED

NCATS 链接诚实经纪人 (LHB) - 以患者为中心的结果研究 (PCOR) 信托基金 ASPE 国家 COVID-19 纵向研究数据库链接

• 批准号: 10722511
• 负责人: UMBERTO TACHINARDI
• 金额: $ 119.96万
• 依托单位: REGENSTRIEF INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10722511
• 关键词: COVID-19; Characteristics; Clinical; Clinical Data; Computer software; Data; Data Set; Databases; Funding; Hospitals; Knowledge; Link; National Center for Advancing Translational Sciences; Outcomes Research; Patient-Focused Outcomes; Patients; Persons; Process; Provider; Records; Research; Research Personnel; Secure; Security; Series; Services; Translational Research; Trust; Vendor; cohort; coronavirus disease; data enclave; member; privacy preservation; response

National COVID-19 Cohort Collaborative (N3C): The N3C Data Enclave is a secure platform storing harmonized clinical data provided by more than 50 contributing members. The Enclave hosts over 651 million clinical observations on over 6.5 million persons, including over 2.1 million COVID cases, amounting to more than 7.3 billion rows of data. Harmonization, anonymity, and security is accomplished through the N3C privacy-preserving record linkage (PPRL). The PPRL uses a de-identified, software-generated token applied by a data contributor to each patient record. A linkage honest broker holds the de-identified tokens and provides a service matching token generated across disparate data sets without knowledge of the identity of the patients. The de-identified tokens are held separately from data residing within the data enclave. As an illustration of the PPRL process, Regenstrief generates a series of de-identified tokens using software provided by Datavant, Inc. The tokens are provided to a data provider, such as Hospital Network Alpha (HNA). HNA strips identifying PII from its clinical records and replaces the PII with the tokens. HNA then uploads the de-identified clinical records to N3C. If researchers require additional information about those records, they provide the token to Regenstrief, who passes it on to HNA without any knowledge of the underlying clinical data. HNA then provides the appropriate response. The linkage honest broker function is critical to the PPRL, which in turn is critical to continued use of the N3C Data Enclave by researchers. The salient characteristic of this requirement is the vendor’s ability to provide uninterrupted linkage honest broker support (harmonization, anonymity, and security) for the N3C Data Enclave.

National Covid-19队列协作（N3C）：N3C数据飞地是一个安全的平台，可存储由50多名贡献成员提供的协调临床数据。飞地对超过650万人（包括超过210万个共同案件）进行了超过6.51亿个临床观察，总计超过73亿行数据。 通过N3C隐私的记录链接（PPRL）来实现协调，匿名和安全性。 PPRL使用数据贡献者在每个患者记录中应用的已鉴定的软件生成的令牌。 Linkage Hondem Broker持有识别的令牌，并提供了在不同数据集中产生的服务匹配的令牌，而无需了解患者的身份。去识别的令牌与位于数据飞地中的数据分开保存。作为PPRL过程的说明，Regenstrief使用Datavant，Inc.提供的软件生成一系列去识别的令牌。将令牌提供给数据提供商，例如医院网络Alpha（HNA）。 HNA条从其临床记录中识别PII并用令牌取代PII。然后，HNA将去识别的临床记录上传到N3C。如果研究人员需要有关这些记录的其他信息，他们将为RegeStrief提供令牌，后者将其传递给HNA，而无需了解基础临床数据。然后，HNA提供适当的响应。 链接诚实的经纪人功能对PPRL至关重要，这反过来对于继续使用研究人员继续使用N3C数据飞地至关重要。此要求的显着特征是供应商能够为N3C数据飞地提供不间断的链接诚实经纪人支持（协调，匿名和安全性）。