Preventing Type 2 Diabetes in At-Risk Youth

预防高危青少年 2 型糖尿病

• 批准号: 7073404
• 负责人: MARGARET GREY
• 金额: $ 54.04万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7073404
• 关键词: African American; Hispanic Americans; age difference; behavior modification; caucasian American; clinical research; clinical trials; coping; depression; diabetes education; disease /disorder prevention /control; exercise; gender difference; health behavior; human subject; human therapy evaluation; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; nurses; nutrition; nutrition related tag; obesity; parents; patient oriented research; racial /ethnic difference; weight control

DESCRIPTION (provided by applicant): With the increasing prevalence of type 2 diabetes (T2DM) in youth, and the potential for these youth to experience the devastating complications of diabetes at an early age, new approaches to diabetes prevention must be developed and tested. In this investigation we propose to: (1) Using a prospective, randomized clinical trial design, we will determine the effect of school-based, multifaceted intervention (nutrition and exercise education, coping skills training, Advanced Practice Nurse (APN) coaching, and infrastructure change) on Body Mass Index (BMI), insulin resistance, adiposity, lipids, health behaviors, depression, and self-efficacy in inner city youth at high risk for T2DM. Responses in the experimental group over 12 months will be compared to those youth who receive a delayed intervention. (2) Secondarily, we will examine the effects of baseline characteristics (age, gender, baseline health behaviors, depression) and family behaviors on the response to the intervention; and (3) Finally, we will explore the experience of youth and family in management of obesity and insulin resistance in the prevention of type 2. To achieve these aims, we will enroll 240 high-risk 6th grade middle school youth. High risk is defined as BMI >85th percentile. Schools will be randomized to experimental or delayed intervention conditions. The experimental intervention is a community-based, multifaceted intervention program that we have extensively pilot-tested and will be conducted in the middle schools in the very high-risk community of New Haven. Data will be collected pre intervention and at 4 and 13 months following using the primary outcome of BMI, insulin resistance. Revised Godin-Shephard Activity Survey and accelerometer data, Eating Habits Questionnaire, Health Behavior Questionnaire, Children's Depression Inventory for the youths and the Health Promoting Lifestyle Profile for the parents. A purposive sample of families will participate in a series of open-ended interviews. Analyses will include repeated measures ANOVA generalized estimating equation method, and grounded theory approaches. It is expected that this important and timely study will provide valuable information to help youth manage obesity, and potentially prevent T2DM and its long-term physical and psychosocial complications.

描述（由申请人提供）：随着年轻人2型糖尿病（T2DM）的患病率的增加，这些年轻人在很小的时候就有可能经历糖尿病的毁灭性并发症，因此必须开发和测试新的预防糖尿病方法。 In this investigation we propose to: (1) Using a prospective, randomized clinical trial design, we will determine the effect of school-based, multifaceted intervention (nutrition and exercise education, coping skills training, Advanced Practice Nurse (APN) coaching, and infrastructure change) on Body Mass Index (BMI), insulin resistance, adiposity, lipids, health behaviors, depression, and self-efficacy in inner city youth at high risk for T2DM。 将在12个月内的实验组中的反应与接受延迟干预的年轻人进行比较。 （2）其次，我们将研究基线特征（年龄，性别，基线健康行为，抑郁症）和家庭行为对干预反应的影响； （3）最后，我们将探讨青年和家庭在预防2型肥胖和胰岛素抵抗管理方面的经验。为了实现这些目标，我们将注册240个高风险的6年级中学青年。 高风险定义为BMI> 85个百分位。 学校将被随机分为实验或延迟干预条件。 实验干预是一项基于社区的多方面干预计划，我们已经进行了广泛的试点测试，并将在纽黑文（New Haven）非常高风险社区的中学进行。 使用BMI，胰岛素抵抗的主要结果后，将在干预前，在4和13个月后收集数据。 修订了Godin-Shephard活动调查和加速度计数据，饮食习惯问卷，健康行为问卷调查，儿童抑郁症库存以及为父母提供健康促进生活方式的状况。 有目的的家庭样本将参加一系列开放式访谈。 分析将包括重复测量方差分析概括方程方法和接地理论方法。 可以预期，这项重要及时的研究将提供有价值的信息，以帮助青年人管理肥胖，并有可能预防T2DM及其长期的身体和社会心理并发症。

项目成果

Metabolic risk and health behaviors in minority youth at risk for type 2 diabetes.

有 2 型糖尿病风险的少数青少年的代谢风险和健康行为。

• DOI: 10.2337/dc10-1197
• 发表时间: 2011
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Holl,MaritaG;Jaser,SarahS;Womack,JulieA;Jefferson,VanessaL;Grey,Margaret
• 通讯作者: Grey,Margaret

A multifaceted school-based intervention to reduce risk for type 2 diabetes in at-risk youth.

• DOI: 10.1016/j.ypmed.2009.07.014
• 发表时间: 2009-08
• 期刊: PREVENTIVE MEDICINE
• 影响因子: 5.1
• 作者: Grey, Margaret;Jaser, Sarah S.;Holl, Marita G.;Jefferson, Vanessa;Dziura, James;Northrup, Veronika
• 通讯作者: Northrup, Veronika