COORDINATING CENTER FOR AMD PREVENTION TRIAL

AMD 预防试验协调中心

• 批准号: 6850383
• 负责人: MAUREEN G MAGUIRE
• 金额: $ 139.52万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-07 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6850383
• 关键词: clinical research; clinical trials; cooperative study; data collection methodology /evaluation; data management; diagnosis quality /standard; disease /disorder prevention /control; eye laser surgery; health care personnel performance; health care service evaluation; health science research support; human data; human therapy evaluation; information systems; macular degeneration; macular drusen; medical complication; statistics /biometry

The Complications of Age-related Macular Degeneration Prevention Trial (CAPT) is a multi-centered, randomized, controlled clinical trial to evaluate light laser photocoagulation as a preventative treatment for the advanced complications of age-related macular degeneration (AMD) in patients with large drusen in each eyes. The Coordinating Center will provide expertise on study design, statistical analysis, data processing and management, and will coordinate the activities of the study group needed to carry out the study. The specific aims of the Coordinating Center to fulfill this role are: . Work with the other members of the study group to further refine the study design; . Provide the infrastructure necessary to support the conduct and monitoring of the study; . Create and maintain the study database through design of data collection forms, data collection and processing, and data editing; . Provide timely, regular reports to the clinical centers, CAPT Reading Center; and CAPT Data and Safety Monitoring Committee concerning study progress and performance; . Provide interim and final statistical analysis of the accumulated data; . Design and implement a full program of quality assurance activities; . Design and implement studies of quality of life assessment; . Assist with the preparation of scientific reports.

与年龄相关的黄斑变性预防试验的并发症 （上尉）是一个以上为中心的，随机的，对照临床试验 评估光激光光凝作为预防性治疗 与年龄相关的黄斑变性（AMD）的晚期并发症 每只眼睛都有大drusen的患者。 协调中心将提供有关研究设计的专业知识， 统计分析，数据处理和管理，并将协调 研究小组的活动需要进行研究。这 协调中心履行此角色的具体目标是： 。与研究小组的其他成员合作，进一步完善 研究设计； 。提供支持行为所必需的基础设施 监测研究； 。通过设计收集来创建和维护研究数据库 表单，数据收集和处理以及数据编辑； 。及时向临床中心提供定期报告，上尉阅读 中心;以及有关研究的上尉数据和安全监测委员会 进步和表现； 。提供累积数据的临时和最终统计分析； 。设计和实施完整的质量保证活动计划； 。设计和实施生活质量评估的研究； 。协助准备科学报告。