Tests of Models of Retinal/Optic Nerve Diseases&Adaption

视网膜/视神经疾病模型的测试

• 批准号: 6795336
• 负责人: DONALD C. HOOD
• 金额: $ 40.88万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6795336
• 关键词: biological models; diabetic retinopathy; electrodes; electrophysiology; electroretinography; eye fundus photography; eye injury; eye surgery; functional magnetic resonance imaging; ganglion cell; glaucoma; human subject; intraocular pressure; light adaptations; optic nerve disorder; optic neuritis; pathologic process; patient oriented research; psychophysics; retina disorder; retinal adaptation; retinitis pigmentosa; visual fields; visual pathways; visual threshold

A major long-term objective is to develop techniques for localizing the sites, and identifying the mechanisms of diseases of the retina and optic nerve. The multifocal electroretinogram (mERG) and visual evoked potential (mVEP) techniques are relatively new ways for measuring the physiological activity of local retinal and cortical activity. By studying the mERGs from patients with a variety of retinal/optic nerve problems we aim to develop a conceptual framework for relating changes in the mERG to sites and mechanisms of damage (aim 1a). In addition, some retinal diseases affect retinal mechanisms of adaptation and studies are designed to understand these changes. The mVEP technique is less developed and studies are proposed to improve this technology. These include the development of a method for measuring and specifying the strength of the signal in the mVEP response (aim 1b). Specific studies are proposed to understand the contribution of cone pathways to the mVEP, to assess repeat reliability, to optimize recording techniques, and to develop norms. The second long-term objective is to improve our understanding of the sites and mechanisms of particular diseases of the retina/optic nerve through studies employing behavioral (e.g. visual fields), structural (e.g. nerve fiber layer analysis) and electrophysiological techniques (e.g. mERG and mVEP). As part of aim 2, the mERG and visual field measures will be employed to better understand retinal damage in patients with retinitis pigmentosa and diabetic retinopathy and to assess possible damage following retinal surgery for macular holes and macular pucker. In addition, the sites and mechanisms of glaucomatous damage will be studied. These studies include a comparison of structural and functional measures to better understand the mechanism(s) of damage, an attempt to detect early damage, an assessment of the effect of acute decreases in intraocular pressure, and an assessment of whether there are selective deficits in the cone pathways. Finally, patients with acute optic neuritis will be followed with behavioral and mVEP techniques. An attempt will be made to understand the recovery o vision following optic neuritis (ON).

一个主要的长期目标是开发用于定位部位的技术，并确定视网膜和视神经的疾病机制。 多焦点电视图（MERG）和视觉诱发电位（MVEP）技术是测量局部视网膜和皮质活动的生理活性的相对较新的方法。通过研究具有各种视网膜/视神经问题的患者的MERG，我们旨在开发一个概念框架，将Merg的变化与损害的部位和机制联系起来（AIM 1A）。 此外，一些视网膜疾病会影响适应性的视网膜机制，研究旨在了解这些变化。 MVEP技术的发达较少，并提出了研究以改善该技术的研究。 这些包括开发一种方法，用于测量和指定MVEP响应中信号强度的强度（AIM 1B）。 提出了具体的研究，以了解锥途径对MVEP的贡献，评估重复可靠性，优化记录技术并制定规范。第二个长期目标是通过采用行为（例如视野），结构（例如神经纤维层分析）和电生理技术（例如Merg和MVEP）的研究（例如，神经纤维层分析）（例如，Merg and MVEP），通过研究（例如视野），结构性（例如神经纤维层分析）的研究来提高我们对视网膜/视神经特定疾病的部位和机制的理解。 作为AIM 2的一部分，将采用MERG和视野测量，以更好地了解色素性视网膜炎和糖尿病性视网膜病患者的视网膜损害，并评估视网膜手术后黄斑孔和黄斑裂口后可能的损害。另外，将研究青光眼损伤的位置和机制。 这些研究包括比较结构和功能措施，以更好地了解损害的机制，试图检测早期损害的尝试，对眼内压力急性降低的影响的评估以及评估锥途径中是否有选择性缺陷的评估。 最后，急性视神经炎患者将采用行为和MVEP技术。 将尝试了解视神经炎（ON）后的恢复视力。